Results 161 to 170 of about 66,132 (287)

Molecular simulations meet personalized medicine: The mechanism of action of CLC-5 antiporter and the origin of Dent's disease. [PDF]

PNAS Nexus
Macaluso V, Pérez C, Soliva R, Westermaier Y, Díaz L, Wieczór M, Orozco M.   +6 more
europepmc   +1 more source

Monosodium Glutamate Induces Oxidative Stress and Affects Glucose Metabolism in the Kidney of Rats

, 2012
Onyema Okwudiri
openalex   +2 more sources

SAGE: Spatially Aware Gene Selection and Dual‐View Embedding Fusion for Domain Identification in Spatial Transcriptomics

Advanced Science, EarlyView.
SAGE is a unified framework for spatial domain identification in spatial transcriptomics that jointly models tissue architecture and gene programs. Topic‐driven gene selection (NMF plus classifier‐based scoring) highlights spatially informative genes, while dual‐view graph embedding fuses local expression and non‐local functional relations.
Yi He, Yunpei Xu, Liqing Ding, Hong‐Dong Li, Yaohang Li, Shaokai Wang   +5 more
wiley   +1 more source

Predicting residue ionization of OmpF channel using Constant pH Molecular Dynamics as benchmark. [PDF]

PLoS Comput Biol
Tavares-Neto E, Aguilella-Arzo M, Aguilella VM.   +2 more
europepmc   +1 more source

Reviewer #2 (Public Review): Bidirectional dysregulation of synaptic glutamate signaling after transient metabolic failure

openalex   +1 more source

Enhancement of Calcium Ion Permeation via Resonant Coupling of Ion and Terahertz Waves in Voltage Gated Calcium Channels

Advanced Science, EarlyView.
We introduce a novel, ion‐targeted strategy to enhance calcium permeation in voltage gated calcium channels. By directly driving the ions’ coherent collective motion via resonant coupling with a 1.65 THz field, we lower the inter‐site energy barrier, inducing a statistically significant enhancement of ion influx.
Zihao Zhang, Yuankun Sun, Xinqiao Zhou, Sunchao Huang, Shengpeng Yang, Shaomeng Wang, Yubin Gong   +6 more
wiley   +1 more source

Flipper dendrimers. [PDF]

Chem Sci
Gonzalez-Sanchis N, Bayard F, García-Arcos JM, Mandal T, Roux A, Sakai N, Matile S.   +6 more
europepmc   +1 more source

PVNCRF Neurons Regulate Migraine‐Like Allodynia by Activating CRFR2 on Spinal Trigeminal Caudalis Glutamatergic Neurons

Advanced Science, EarlyView.
Paraventricular CRF neurons in the hypothalamus project to glutamatergic neurons of the spinal trigeminal caudal nucleus, enhancing neuronal activation and CRFR2 signaling. This pathway increases CRF release and excitatory drive, promoting central sensitization and migraine‐related behaviors. Targeting the PVN–SP5C circuit provides a potential strategy
Jiang Bian, Xiao‐Long Wang, Li Yin, Wei Wei, Xue Li, Yao Ge, Zhao‐Xia Xiang, Na Tian, Li‐Juan Chen, Ming‐Wei Ma, Xia Zhang, Xu Jing, Mei‐Yun Wang, Xu‐Feng Xu   +13 more
wiley   +1 more source

Electronic and Structural Heterogeneity in the Diiron Center of Sulerythrin: Insights From Hybrid QM/MM Calculations. [PDF]

Chemphyschem
Moubarak S, Mroginski MA.
europepmc   +1 more source

AML‐Targeted Metal‐Polyphenol Nanoplatform Induces Ferroptosis‐ICD Cascade for Antitumor Immunity Boosting

Advanced Science, EarlyView.
Schematic illustration of the synthesis protocol for Fe‐SH@Fn, an AML‐targeted nanoplatform engineered to co‐deliver shikonin (SH) and Fe3+, synergistically boosting antitumor immunity via ferroptosis induction and immunogenic cell death (ICD). ABSTRACT Acute myeloid leukemia (AML) remains a therapeutic challenge due to its low immunogenicity and ...
Shangqin Yang, Jingxuan Wang, Kerong Tu, Xiaobing Huang, Liangliang Lv, Mingjie Peng, Qiqi Xu, Hongmei Liu, Qiang Sun, Lulu Cai   +9 more
wiley   +1 more source