Results 191 to 200 of about 8,454 (258)

Atypical Condensation Domains Guide Discovery and Illuminate Biosynthesis of Myxoglucamides Featuring Vinyl‐Substituted, α‐Oxidized γ‐Amino Acids

Angewandte Chemie, EarlyView.
Genome mining of atypical condensation (C) domains leads to the discovery of myxoglucamides, glycolipopeptides featuring an unprecedented vinyl‐substituted, α‐oxidized γ‐amino acid. Biosynthetic studies reveal a discrete C‐domain‐like O‐acyltransferase, a β‐hydroxylation‐dependent chain‐extension checkpoint, and an unusual pathway for γ‐amino acid ...
Tingting Wang, Alexander Popoff, Maja Hunter, Guangzhi Dai, Ronald Garcia, Huixin Xu, Haowen Zhao, Asfandyar Sikandar, Liujie Huo, Rolf Müller, Chengzhang Fu   +10 more
wiley   +2 more sources

Tubulin glutamylation: a key regulator of flagella, cilia, centrosomes, and disease pathways. [PDF]

J Biomed Sci
Chen SC, Chuang YC, Lin YC.
europepmc   +1 more source

Unraveling A4GALT Mechanism and Its Modulation With Adamantyl‐Galactosylceramide Analogues: Advancing Fabry Disease Therapeutic Strategies

Angewandte Chemie, EarlyView.
A 310‐helix‐mediated conformational switch promotes a front‐face SNi‐like catalysis by human A4GALT. Mechanism‐guided design identifies AdaGalCer as a selective modulator of globotriaosylceramide (Gb3) biosynthesis, opening a clear route toward new Fabry disease therapeutics.
Nicky de Koster, Òscar Vidal‐Gironès, Rowan de Graaf, Ken Kok, Lindsey T. Lelieveld, Jackelien Hoogervorst, Maria J. Ferraz, José Pablo Rivas‐Fernández, Rob F. Lammers, Herman S. Overkleeft, Johannes M. F. G. Aerts, Rolf G. Boot, Carme Rovira, Marta Artola   +13 more
wiley   +2 more sources

Proteome-Wide Covalent Targeting of Acidic Residues with Tunable <i>N</i>-Aryl Aziridines. [PDF]

J Am Chem Soc
Qiu N, Tan H, Pechalrieu D, Abegg D, Fnu D, Powers DC, Adibekian A.   +6 more
europepmc   +1 more source

Evaluation of TOCSY mixing for sensitivity-enhancement in solid-state NMR and application of 4D experiments for side-chain assignments of the full-length 30 kDa membrane protein GlpG. [PDF]

J Biomol NMR
Öster C, Chevelkov V, Lange A.
europepmc   +1 more source

Antibiotic-Free Expression of γ-Glutamyl Transpeptidase in <i>Bacillus subtilis</i> and Process Optimization for L-Theanine Separation and Purification. [PDF]

Molecules
Zhang R, Jiang B, Xiao Z, Xiang L.
europepmc   +1 more source

Cofactor F₄₂₀ tail length distribution in different environmental samples. [PDF]

Heliyon
Wunderer M, Markt R, Prem EM, Peer N, Mullaymeri A, Wagner AO.   +5 more
europepmc   +1 more source

A Novel Perspective on Lead-Induced Protamine-like Protein-DNA Interactions in <i>Mytilus galloprovincialis</i>: A Molecular and Computational Study. [PDF]

Biomolecules
Marinaro C, Amore S, Garofalo R, Sebastiano B, Santaniello G, Cafaro S, Sansone D, Di Giovanni C, Lettieri G, Piscopo M.   +9 more
europepmc   +1 more source

L-Theanine mitigates skin aging in rats via modulation of the AGEs-RAGE pathway, enhancement of antioxidant defense, and attenuation of inflammation. [PDF]

Sci Rep
Xu D, Yang Y, Zheng X, Wang F, Liu Z.
europepmc   +1 more source

Screening single nucleotide changes to tropomyosin to identify novel cardiomyopathy mutants. [PDF]

J Mol Cell Cardiol
Wen J, Campbell S, Moore J, Lehman W, Rynkiewicz M.   +4 more
europepmc   +1 more source