Results 231 to 240 of about 9,046 (297)

L-Theanine mitigates skin aging in rats via modulation of the AGEs-RAGE pathway, enhancement of antioxidant defense, and attenuation of inflammation. [PDF]

Sci Rep
Xu D, Yang Y, Zheng X, Wang F, Liu Z.
europepmc   +1 more source

A nanoplatform that induces dual‐amino acid deprivation to reverse tumor immunosuppression and enhance metabolic immunotherapy

BMEMat, EarlyView.
ZIF‐8‐based nanoparticles co‐delivering CB‐839 (glutaminase inhibitor) and 1‐MT (IDO1 inhibitor), dual‐targeting glutamine/tryptophan metabolism to induce immunogenic cell death, activate STING, block kynurenine production, reverse immunosuppression, and enhance cancer immunotherapy to suppress primary/distant tumors.
Wenli Ning, Yunhan Sun, Mingyang Li, Shilu Liu, Fangjie Yi, Hongfei Wang, Ruibing Bai, Dongdong Liu, Fen Zhao, Guiqiang Zhang, Xiao Fu   +10 more
wiley   +1 more source

Cofactor F₄₂₀ tail length distribution in different environmental samples. [PDF]

Heliyon
Wunderer M, Markt R, Prem EM, Peer N, Mullaymeri A, Wagner AO.   +5 more
europepmc   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Screening single nucleotide changes to tropomyosin to identify novel cardiomyopathy mutants. [PDF]

J Mol Cell Cardiol
Wen J, Campbell S, Moore J, Lehman W, Rynkiewicz M.   +4 more
europepmc   +1 more source

Orchestrating the metastatic symphony: the role of extracellular vesicles in the epithelial–mesenchymal transition and pulmonary niche formation of breast cancer

Biological Reviews, EarlyView.
ABSTRACT The complexity of breast cancer (BC) lung metastasis lies in the capacity of tumour cells to interact efficiently with distant organs to promote colonisation, a process that involves the sophisticated coordination of inherent cellular plasticity and the remodelling of the distant microenvironment.
Jian Lu, Reza Shirazi Nia, Junjie Sun, Chrysa Filippopoulou, Daniel De Vega, Pengtao Hu, Heng Liang, Hang Yao, Chaoyue Pan, Xiaoyan Wu, Xidong Gu, Xiaohong Xie, Georgios Giamas   +12 more
wiley   +1 more source

GPIHBP1 on oligodendrocytes binds lipoprotein lipase within the human brain. [PDF]

Proc Natl Acad Sci U S A
Liu M, Hung M, Kozlov E, Hung M, Colaço-Gaspar M, Roy S, Tu Y, Magaki SD, Williams CK, Andaloussi Mäe M, Johnson ECB, Siegel RW, Konrad RJ, Ploug M, Betsholtz C, Beigneux AP, He L, Fong LG, Young SG.   +18 more
europepmc   +1 more source

Oocyte–cumulus cell interaction: a key factor in early embryo development

Biological Reviews, EarlyView.
ABSTRACT The evaluation of oocyte competence is a fundamental step in achieving successful outcomes following assisted reproduction techniques (ART). At present, however, conventional oocyte maturation assessment is carried out by morphological observation, which is a subjective method that does not consider molecular features.
Marc Torres‐Garrido, Marc Yeste, Yentel Mateo‐Otero   +2 more
wiley   +1 more source

A specific negatively charged sequence confers intramolecular regulation on Munc13-1 function in synaptic exocytosis. [PDF]

Proc Natl Acad Sci U S A
Zhao K, Zhang L, Lei M, Jin Z, Du T, Zhang H, Sheng Y, Hu Z, Wang S, Ma C, Ma C.   +10 more
europepmc   +1 more source

Enantioselective Hydration of Non-CoA Enoyl-Thioesters by Enoyl-CoA Hydratase (ECH): Activation of the Active Site Oxyanion Hole with 3',5'-Adenosine-Diphosphate Enables Competent Catalysis. [PDF]

JACS Au
Dalwani S, Mondal PK, Schmitz W, Wierenga RK, Pihko PM.   +4 more
europepmc   +1 more source