Results 281 to 290 of about 226,956 (383)

4-Amino-4-cyanobutyric Acid as an Intermediate in Glutamate Biosynthesis

, 1967
Gary A. Strobel
openalex   +1 more source

Targeted Proteomics upon Treatment with Tofersen Identifies Novel Response Markers for Superoxide Dismutase 1‐Linked Amyotrophic Lateral Sclerosis

Annals of Neurology, EarlyView.
Objective Tofersen is the first effective and approved therapy for superoxide dismutase 1 (SOD1)‐associated amyotrophic lateral sclerosis (ALS [SOD1‐ALS]). Following treatment with tofersen, neurofilament levels in patients' cerebrospinal fluid (CSF) and serum seem to respond earlier than clinical parameters.
Christina Steffke, Karthik Baskar, Franziska Bachhuber, Maximilian Wiesenfarth, Johannes Dorst, Joachim Schuster, Florian Schöberl, Peter Reilich, Martin Regensburger, Alexander German, René Günther, Maximilian Vidovic, Susanne Petri, Thomas Meyer, Tim Hagenacker, Julian Grosskreutz, Ute Weyen, Patrick Weydt, Thomas Haarmeier, Paul Lingor, Joachim Wolf, Andreas Hermann, Johannes Prudlo, Kornelia Günther, Antje Knehr, Zeynep Elmas, Zeljko Uzelac, Simon Witzel, Wolfgang Philipp Ruf, Axel Freischmidt, Ritchie Ho, Albert C. Ludolph, Jochen H. Weishaupt, Hayrettin Tumani, Patrick Oeckl, David Brenner, Alberto Catanese   +36 more
wiley   +1 more source

Moderately thermostable GH1 β-glucosidases from hyperacidophilic archaeon Cuniculiplasma divulgatum S5. [PDF]

FEMS Microbiol Ecol
Khusnutdinova AN, Tran H, Devlekar S, Distaso MA, Kublanov IV, Skarina T, Stogios P, Savchenko A, Ferrer M, Golyshina OV, Yakunin AF, Golyshin PN.   +11 more
europepmc   +1 more source

Buried Treasure? Overlooked and Newly Discovered Evolutionary Contributions to Human Brain Diseases

Annals of Neurology, EarlyView.
Recapitulative schema of different exploratory levels of the evolutionary impact on human neurological diseases. Clinical neuroscience focuses on the mechanisms of brain function, but this approach falls short of insights into how the central nervous system (CNS) evolved, both in health and disease.
Nico J. Diederich, Martin Brüne, John S. Allen, Nicole Bender, Emiliano Bruner, Jean‐Pierre Changeux, Corrado Cali, Olga Dolgova, Anne Grünewald, Geneviève Konopka, Peng Jin, Roger Lemon, Gilberto Levy, Pierre Magistretti, Markus J. Rantala, Kathleen S. Rockland, Roger Sullivan, Annie Swanepoel, Toshiki Uchihara, Katrin Amunts, Christopher G. Goetz   +20 more
wiley   +1 more source

In Silico Description of the Direct Inhibition Mechanism of Endothelial Lipase by ANGPTL3. [PDF]

Int J Mol Sci
Montavoci L, Ben Mariem O, Saporiti S, Laurenzi T, Palazzolo L, Ossoli AF, Guerrini U, Calabresi L, Eberini I.   +8 more
europepmc   +1 more source

Back Again to the Future: A New Era for Cerebroprotection

Annals of Neurology, EarlyView.
Cerebroprotection is a fresh framework for designing neurological therapy that targets glia and vascular cells, in addition to neurons. In the future, successful cerebroprotection will involve targeting all elements of the neurovascular unit. Preclinical trials must include functional outcomes, as well as lesion morphometry.
Patrick Lyden
wiley   +1 more source

Bismuth–Selenopeptides Combine Potent Bioactivity with Exceptional Kinetic Inertness

Angewandte Chemie, EarlyView.
A major obstacle for bismuth peptides and proteins, in which Bi(III) is coordinated by three cysteine residues, is their kinetic lability when challenged with strong metal chelators. By simply replacing cysteines with selenocysteines, we significantly increased kinetic stability, extending the lifetime to several days.
Pritha Ghosh, Minghao Shang, Katarina Trajković, Lani J. Davies, Upamali Somathilake, Toshiki Takei, Hironobu Hojo, Christoph Nitsche   +7 more
wiley   +2 more sources

L-Theanine Ameliorates Metabolic Dysregulation and Adverse Fetal Outcomes in a Mice Model of Gestational Obesity: Association with FXR/FGF15 Signaling. [PDF]

J Microbiol Biotechnol
Huang L, Li H, Yang W, Huang L, Chen Q, Li S, Zou Z, Zhao L, Zeng Z.   +8 more
europepmc   +1 more source

Approaches to Enhance Photodynamic Therapy of Lung Cancer: Potential Application of Nanoparticles

Advanced NanoBiomed Research, EarlyView.
Bioactive ligand‐targeted nanocarriers can accommodate functionalization with numerous targeting ligands for effective delivery of photosensitizers (PSs) within targeted photodynamic therapy. Various targeting moieties including peptides, antibodies, carbohydrates, aptamers, proteins, and PS anticancer molecules can be attached to nanomaterials.
Nokuphila Winifred Nompumelelo Simelane, Heidi Abrahamse   +1 more
wiley   +1 more source

Alternative Import-Channels And Destinations Of Mitochondrial PINK1 Controlled By Trans-Membrane-Domain Structural Plasticity

Lorriman JS, Grieve AG, Corey RA, Collinson I.   +3 more
europepmc   +1 more source