Results 311 to 320 of about 226,163 (382)

Folates, bacteria and ageing: insights from the model organism <i>C. elegans</i> in the study of nutrition and ageing. [PDF]

Proc Nutr Soc
Weinkove D.
europepmc   +1 more source

The FindMNDBiomarker Program: Protein Changes in Motor Neuron Disease/Amyotrophic Lateral Sclerosis Postmortem Tissue and Biofluids

Annals of Neurology, EarlyView.
Objective Biomarkers of disease pathogenesis are critically needed for amyotrophic lateral sclerosis (ALS) to facilitate diagnosis and patient stratification into appropriate therapeutic trials. Proteomic studies offer significant potential to advance this, but reproducibility across laboratories is a key component toward identifying protein changes ...
Gabrielle L. Adler, Matthew C. Kiernan, Rachel H. Tan   +2 more
wiley   +1 more source

KaiC family ATPases in the nonheterocystous nitrogen-fixing cyanobacterium Leptolyngbya boryana. [PDF]

Sci Rep
Matsukami Y, Oyama K, Azai C, Onoue Y, Fujita Y, Terauchi K.   +5 more
europepmc   +1 more source

Targeted Proteomics upon Treatment with Tofersen Identifies Novel Response Markers for Superoxide Dismutase 1‐Linked Amyotrophic Lateral Sclerosis

Annals of Neurology, EarlyView.
Objective Tofersen is the first effective and approved therapy for superoxide dismutase 1 (SOD1)‐associated amyotrophic lateral sclerosis (ALS [SOD1‐ALS]). Following treatment with tofersen, neurofilament levels in patients' cerebrospinal fluid (CSF) and serum seem to respond earlier than clinical parameters.
Christina Steffke, Karthik Baskar, Franziska Bachhuber, Maximilian Wiesenfarth, Johannes Dorst, Joachim Schuster, Florian Schöberl, Peter Reilich, Martin Regensburger, Alexander German, René Günther, Maximilian Vidovic, Susanne Petri, Thomas Meyer, Tim Hagenacker, Julian Grosskreutz, Ute Weyen, Patrick Weydt, Thomas Haarmeier, Paul Lingor, Joachim Wolf, Andreas Hermann, Johannes Prudlo, Kornelia Günther, Antje Knehr, Zeynep Elmas, Zeljko Uzelac, Simon Witzel, Wolfgang Philipp Ruf, Axel Freischmidt, Ritchie Ho, Albert C. Ludolph, Jochen H. Weishaupt, Hayrettin Tumani, Patrick Oeckl, David Brenner, Alberto Catanese   +36 more
wiley   +1 more source

Discovery of hybrid Glypromate conjugates with neuroprotective activity against paraquat-induced toxicity. [PDF]

RSC Med Chem
Silva-Reis SC, Costa VM, da Silva DC, Pereira DM, Correia XC, García-Mera X, Rodríguez-Borges JE, Sampaio-Dias IE.   +7 more
europepmc   +1 more source

Approaches to Enhance Photodynamic Therapy of Lung Cancer: Potential Application of Nanoparticles

Advanced NanoBiomed Research, EarlyView.
Bioactive ligand‐targeted nanocarriers can accommodate functionalization with numerous targeting ligands for effective delivery of photosensitizers (PSs) within targeted photodynamic therapy. Various targeting moieties including peptides, antibodies, carbohydrates, aptamers, proteins, and PS anticancer molecules can be attached to nanomaterials.
Nokuphila Winifred Nompumelelo Simelane, Heidi Abrahamse   +1 more
wiley   +1 more source

Sequences and Structures of Viral Proteins Linked to the Genomes (VPg) of RNA Viruses. [PDF]

Viruses
Schein CH.
europepmc   +1 more source

Impact of Interfacial Viscosity on the Robustness of Phospholipid‐Decorated Fluid Cell Scaffolds

Advanced NanoBiomed Research, EarlyView.
Viscosity‐tunable fluid scaffolds are developed by decorating a perfluorocarbon interface with phospholipid membranes (IPLMs) of varying unsaturated lipid contents. A solid‐like IPLM is cell‐adhesive but brittle, whereas the least viscous IPLM does not allow cell adhesion. Moderately viscous IPLMs serve as highly adaptive cellular scaffolds.
Junhong Zhou, Jun Nakanishi
wiley   +1 more source

Structural basis for the activity regulation of Medicago calcium channel CNGC15. [PDF]

Cell Discov
Xu X, Wang Q, Sun T, Gao H, Gu R, Yang J, Zhou J, Fu P, Wen H, Yang G.   +9 more
europepmc   +1 more source

Erweiterung des Repertoires an lichtschaltbaren unnatürlichen Aminosäuren für das Enzym‐Engineering

Angewandte Chemie, EarlyView.
Enzym‐Engineering mit lichtschaltbaren unnatürlichen Aminosäuren (lsUAs) birgt ein hohes Potenzial für Anwendungen wie die Biokatalyse. Wir erweitern hier das aktuell vorhandene Repertoire mit lsUAs, welche vielseitigere Eigenschaften aufweisen, um den Weg für eine fortschrittlichere Etablierung der Lichtkontrolle in Enzymen zu ebnen. Wir berichten die
Caroline Hiefinger, Michela Marcon, Verena Pape, Guillem Casadevall, Ranit Lahmy, Christoph Haag, Julian Nazet, Michael Bartl, Astrid Bruckmann, Sílvia Osuna, Burkhard König, Andrea Hupfeld   +11 more
wiley   +1 more source