Mitochondrial subpopulations promote cellular responses to changes in metabolic demand and signal transduction. [PDF]
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Glutamine metabolism drives tumor aggressiveness but not chemoresistance in ovarian carcinoma cell lines. [PDF]
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Recent Development of Small Molecule Glutaminase Inhibitors
Current Topics in Medicinal Chemistry, 2018 Glutaminase (GLS), which is responsible for the conversion of glutamine to glutamate, plays a vital role in up-regulating cell metabolism for tumor cell growth and is considered to be a valuable therapeutic target for cancer treatment.
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