Results 161 to 170 of about 19,538 (222)

Glutaminase activity maintains NK cell cytotoxicity through metabolic regulation of effector function. [PDF]

J Inflamm (Lond)
Jedlička M, Feglarová T, Švubová V, Mašínová E, Graman V, Kuglerová K, Szabová J, Jahan F, Korhonen M, Kuželová K, Hortová-Kohoutková M, Frič J.   +11 more
europepmc   +1 more source

Vitamin D supports activated CD4⁺ T-cell proliferation through enhanced glutaminolysis. [PDF]

Front Immunol
Vera AA, Hernandez M, Cartes RA, Llerena F, Cisterna SE, Quiroga RA, Sanhueza SA, Muñoz-Grez CP, Vergara F, Moena D, Alarcón PA, Burgos R, Rivas CI, Uribe E, Argüello RJ, Almarza C, Urra FA, Tapia-Belmonte F, Ferrada L, Lamperti LI, Nova-Lamperti E.   +20 more
europepmc   +1 more source

Dietary Fatty Acids Differentially Modulate Hippocampal Glutamate-Related Gene Expression in Mice: Sex-Specific in Vivo and in Vitro Effects. [PDF]

Mol Nutr Food Res
Romero-Muñoz L, Merino B, Sánchez-Hita E, Sanz-Martos AB, Casado ME, Domingo-Martínez M, Plaza A, Morales L, García A, Fernández-Hernández C, Fernández-Felipe J, Olmo ND, Marcos A, Chowen JA, Ruiz-Gayo M, Cano V.   +15 more
europepmc   +1 more source

Cancer metabolism: from the Warburg effect to precision therapy. [PDF]

Front Immunol
Wang C, Wang J, Miao L, Wei L, Liu X, Lu Y, Xiang L, Zhang M.   +7 more
europepmc   +1 more source

Characterization and bioactivities of glutaminase-free L-asparaginase from Salinicola acorporae S4-41. [PDF]

Microb Cell Fact
El-Shanshoury AER, Abosamra HH, Elsakhawy T.   +2 more
europepmc   +1 more source

Phosphate-activated glutaminase expression during tumor development [PDF]

FEBS Letters, 1994
Changes in phosphate-activated glutaminase activities determined in intact cells and isolated mitochondria have been followed during mouse Ehrlich ascites carcinoma development. Glutaminase activities parallel the levels of poly(A)+ RNAs encoding for the
Miguel Angel Medina, Juan Carlos Aledo, J A Segura   +2 more
exaly   +2 more sources

Recent Development of Small Molecule Glutaminase Inhibitors

Current Topics in Medicinal Chemistry, 2018
Glutaminase (GLS), which is responsible for the conversion of glutamine to glutamate, plays a vital role in up-regulating cell metabolism for tumor cell growth and is considered to be a valuable therapeutic target for cancer treatment.
Soong-Hyun Kim, Hee-Jong Hwang
exaly   +2 more sources

Upregulation of the Glutaminase II Pathway Contributes to Glutamate Production upon Glutaminase 1 Inhibition in Pancreatic Cancer

Proteomics, 2019
The targeting of glutamine metabolism specifically via pharmacological inhibition of glutaminase 1 (GLS1) has been translated into clinical trials as a novel therapy for several cancers. The results, though encouraging, show room for improvement in terms
Ajit Thomas, Khoa Pham
exaly   +2 more sources

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Glutaminases

2016
Mammalian glutaminases catalyze the stoichiometric conversion of L-glutamine to L-glutamate and ammonium ions. In brain, glutaminase is considered the prevailing pathway for synthesis of the neurotransmitter pool of glutamate. Besides neurotransmission, the products of glutaminase reaction also fulfill crucial roles in energy and metabolic homeostasis ...
Javier, Márquez, José M, Matés, José A, Campos-Sandoval   +2 more
openaire   +2 more sources

Tumor Glutaminase Purification

Protein Expression and Purification, 1995
Two alternative purification schemes to obtain the glutaminase from Ehrlich tumor cells in a highly purified form have been developed. One experimental approach is based on conventional and high-performance liquid chromatography fractionation techniques, yielding a 37-fold higher purification than has been previously reported.
J A, Segura, J C, Aledo, S, Gómez-Biedma, I, Núñez de Castro, J, Márquez   +4 more
openaire   +2 more sources