Results 281 to 290 of about 750,830 (294)

Lifespan‐Regulated CAR‐Macrophages from Myeloid Progenitors for Enhanced Colorectal Cancer Therapy

Advanced Science, EarlyView.
Using a tamoxifen‐inducible Hoxb8 system, proliferative bone marrow progenitors can be generated, which are subsequently engineered with an anti‐CEA CAR construct containing a suicide gene (iCas9) and differentiated into CAR‐macrophages. This method facilitates scale up the production of CAR‐macrophages.
Chuancheng Gao, Fangling Hong, Yao Dong, Yong Fu, Yunong Ma, Xuedi Sun, Junfeng Zhang, Jiangning Chen, Zhen Huang   +8 more
wiley   +1 more source

Glutamine-driven metabolic reprogramming promotes CAR-T cell function through mTOR-SREBP2 mediated HMGCS1 upregulation in ovarian cancer. [PDF]

J Transl Med
Chen J, Zhao L, Li W, Wang S, Li J, Lv Z, Zhao Y, Liang J, Hu Z, Pan F, He L, Gu L, Guo Z.   +12 more
europepmc   +1 more source

Nrf2 Drives Epigenetic Reprogramming and Acts as the Master Regulator of KLF4 Expression and Activity in Arsenic‐Induced Transformation

Advanced Science, EarlyView.
Nrf2 isn't just a protector—it's a driver of cancer stemness. The study uncovers how arsenic‐activated Nrf2 directly upregulates KLF4, a key pluripotency factor, fueling oncogenic reprogramming. Through enhancer activation and self‐reinforcing loop, Nrf2 and KLF4 co‐opt gene networks linked to epithelial‐to‐mesenchymal transition and tumor growth ...
Ziwei Wang, Zhuoyue Bi, Jessica Bamrah, Yiran Qiu, Wenxuan Zhang, Bandar Saeed Almutairy, Haoyan Ji, John D. Haley, Chitra Thakur, Fei Chen   +9 more
wiley   +1 more source

NMR-Based Serum Metabolomics and Correlation Analysis Unraveled Metabolic Alterations Underlying Pathophysiology of Type 2 Diabetes Mellitus. [PDF]

ACS Omega
Trivedi R, Kumar S, Kumar P, Yadav S, Shiv S, Kumar D.   +5 more
europepmc   +1 more source

A Compartmentalized Joint‐on‐chip (JoC) Model to Unravel the Contribution of Cartilage and Synovium to Osteoarthritis Pathogenesis

Advanced Science, EarlyView.
A compartmentalized joint‐on‐chip (JoC) platform is here developed, modelling the interactions between cartilage and synovium in osteoarthritis (OA). Using independent culture and mechanical/biochemical stimulation, the JoC revealed how inflammation and mechanical damage drive mutual tissue changes.
Cecilia Palma, Shima Salehi, Michela Anna Polidoro, Matteo Moretti, Marco Rasponi, Silvia Lopa, Paola Occhetta   +6 more
wiley   +1 more source

Glutamatergic and GABAergic metabolite levels in Alzheimer's disease: a systematic review and meta-analysis. [PDF]

BMC Neurol
Ebrahimi R, Mohammad Soltani S, Masouri MM, Seifi M, Ghafourian K, Noori S.   +5 more
europepmc   +1 more source

Liver-specific glucagon dysfunction promotes PP-cell hyperplasia and formation of glucagon and PP double-positive cells. [PDF]

PLoS One
Nakagawa Y, Horii T, Fukunaka A, Sato T, Zhang Z, Kobayashi M, Kitamura T, Hayashi Y, Nishimura T, Hatada I, Fujitani Y.   +10 more
europepmc   +1 more source

High-Resolution Mapping of Tumor and Peritumoral Glutamate and Glutamine in Gliomas Using 7-T MRSI. [PDF]

Radiol Imaging Cancer
Hangel G, Lazen P, Cadrien C, Chambers S, Furtner J, Hingerl L, Strasser B, Kiesel B, Mischkulnig M, Preusser M, Roetzer-Pejrimovsky T, Wöhrer A, Bogner W, Rössler K, Trattnig S, Widhalm G.   +15 more
europepmc   +1 more source

Central Neurophysiological Alterations in Dystrophic mdx Mice Correlate With Reduced Hippocampal Levels of the Endogenous NMDA Receptor Ligand D-Aspartate. [PDF]

J Neurochem
Mastrostefano F, Garofalo M, Nuzzo T, Bruno C, Errico F, Usiello A, De Stefano ME.   +6 more
europepmc   +1 more source