Results 281 to 290 of about 760,519 (335)

Directed rescue strategy for enhanced implant osteointegration in aged rats. [PDF]

Nat Commun
Li X, Jiang X, He Y, Xiong H, Huang Q, Xu K, Luo XX, Li K, Tao B, Zha K, Wu J, Liu P, Cai K.   +12 more
europepmc   +1 more source

MMP2‐Responsive Liposomes Targeting LDLR Enhance the Effectiveness of Anti‐Cancer Drugs in Treating Melanoma

Advanced Therapeutics, EarlyView.
A bi‐functional liposomal system is developed to enhance melanoma therapy, combining mApoE‐mediated targeting of LDLR‐expressing tumor cells with MMP2‐responsive drug release. Loaded with Pimasertib, the liposomes improve intracellular delivery, reduce melanoma viability, and inhibit 3D spheroid growth and invasiveness.
Antonio Renda, Antonia I. Antoniou, Marika Quadri, Susanna Comi, Arianna Amenta, Silvia Sesana, Sara Pellegrino, Pierfausto Seneci, Marcus Koch, Vanna Denti, Giuseppe Paglia, Elisabetta Palazzo, Roberta Lotti, Alessandra Marconi, Francesca Re   +14 more
wiley   +1 more source

Acylation modification-mediated metabolism reprogramming in cancer. [PDF]

iScience
Huang K, Wang Y, Li B, Xiu Y, Zhan H, Wei G, Duan Y.   +6 more
europepmc   +1 more source

NARFL Knockout Triggers Ferroptosis‐Driven Vascular Endothelial Dysfunction

Advanced Science, EarlyView.
NARFL is vital for CIA and oxidative stress resistance. NARFL deletion in HPMEC cells, zebrafish, and mice is lethal and rescued by a Ferroptosis inhibitor. NARFL deficiency disrupted its interaction with CIA proteins, decreased aconitase activity, increased IRP1 activity, induced Fe overload, and led to ferroptosis and oxidative stress, resulting in ...
Hui Hu, Jing Luo, Li Yu, Daoxi Qi, Boyu Li, Yating Chen, Chen Wang, Xiaokang Zhang, Wenzheng Guo, Qiyong Lou, Gang Zhai, Yonglin Ruan, Jianfei Huang, Shengchi Shi, Zhan Yin, Fang Zheng   +15 more
wiley   +1 more source

Intracellular glutamine fluctuates with nitrogen availability and regulates <i>Mycobacterium smegmatis</i> biofilm formation. [PDF]

J Bacteriol
Varner E, Meyer M, Whalen J, Wang Y-H, Rodriguez C, Malik I, Mullet SJ, Gelhaus SL, DePas WH.   +8 more
europepmc   +1 more source

Metformin Restores Mitochondrial Function and Neurogenesis in POLG Patient‐Derived Brain Organoids

Advanced Science, EarlyView.
Patient‐derived POLG‐mutant cortical organoids reveal neuronal subtype‐specific mitochondrial and synaptic defects, with dopaminergic neurons most affected. Metformin treatment restores neuronal identity, mitochondrial function, and excitability, increased mtDNA maintenance, and reprogrammed metabolism via TCA and redox pathways.
Zhuoyuan Zhang, Tsering Yangzom, Ning Lu, Shenglong Deng, Xianglu Xiao, Guang Yang, Kristina Xiao Liang   +6 more
wiley   +1 more source

Effect of glutamine and arginine treatment on the inflammatory response in a rat model of pulmonary contusion. [PDF]

Kardiochir Torakochirurgia Pol
Musayev S, Karacam V, Yılmaz PA, Tertemiz KC, Sevinç M, Ergur BU, Sanlı A, Ozdemir N.   +7 more
europepmc   +1 more source

Growth and immunity of weaner piglets supplemented with dietary tryptophan threonine and glutamine

, 2016
Stenelle Greaves
openalex   +1 more source

Single‐Cell RNA Sequencing of Retina Reveals Nna1 Upregulation in Myopic Diabetic Retinopathy as a Protective Factor Against Diabetic Damage

Advanced Science, EarlyView.
This study investigates a schematic overview of the mechanistic pathways. The relationship between myopia and DR has long been of clinical interest. In diabetic mice, Nna1 expression is downregulated, whereas in diabetic mice with FDM, Nna1 expression is upregulated–particularly in Müller cells–accompanied by decreased vascular endothelial growth ...
Lihui Xie, Yingjun Cai, Bolin Chen, Bowen Li, Jing Zou, Huizhuo Xu   +5 more
wiley   +1 more source

Influence of growth factors and different supplements on metabolic response and productivity of IgA-producing CHO cell lines. [PDF]

J Genet Eng Biotechnol
Ping Y, Viktoriia T, Baohang L, Victoria A.   +3 more
europepmc   +1 more source