Results 291 to 300 of about 760,519 (335)

Cancer Immunotherapy via Disruption of Integrin αvβ3 and CD47 Costabilization on Cancer Cell Surface

Advanced Science, EarlyView.
This study identifies a cancer‐specific interaction between CD47 and integrin αvβ3 that facilitates immune evasion. A rationally designed peptide, PSFL‐NK13, disrupts this axis, enhancing macrophage‐mediated phagocytosis and suppressing tumor growth without inducing anemia.
Peng‐Cheng Yu, Chen‐Xi Yue, Wen‐Zhong Dong, Cui‐Yun Hao, Yi‐Fan Qiao, Di Liu, Xin Zhang, Qi Zhan, Jia‐Bao Yao, Dong‐Ping Wang, Peng Cao, Ying‐Zhe Fan, Ye Yu   +12 more
wiley   +1 more source

Glutamine metabolism and ammonia death: targeted modulation for enhanced cancer immunotherapy. [PDF]

Front Immunol
Du F, Xiao L, Guojun W, Dai Q, Li J, Zhao X, Zhang Q, Yang L, Liu Y, Hu Y, Wen B, Zhou J, Dai J, Zhang W, Zhang Z.   +14 more
europepmc   +1 more source

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

Advanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva, Sara Duarte‐Silva, Pedro M. Martins, Beatriz Rodrigues, Débora Serrenho, Daniela Vilasboas‐Campos, Andreia Teixeira‐Castro, Julio Vieyto‐Nuñez, Joel Mieres‐Perez, Francisco Figueiredo, Martyna Podlasiak, Tatiana Van‐der‐Kellen, Joana Fraga, James Noble, Carter Lantz, Niki Sepanj, Daniela Monteiro‐Fernandes, Sara Guerreiro, Andreia Neves‐Carvalho, Joana Pereira‐Sousa, Frank‐Gerrit Klärner, Thomas Schrader, Joseph A. Loo, Annalisa Pastore, Elsa Sanchez‐Garcia, Gal Bitan, Ana Luísa Carvalho, Patrícia Maciel, Sandra Macedo‐Ribeiro   +28 more
wiley   +1 more source

Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis

Advanced Science, EarlyView.
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang, Yang Hu, Feiyu Wang, Xintao Peng, Honggang Qi, Yuanyuan Yao, Canyu Zhang, Lijie Zhou, Xuemei Liang, Kang Xu, Cong Zhang, Aifeng Zhang, Chen Chen, Yu Zeng, Chenchen Zhang, Guangming Gan, Xinjian Zhu   +16 more
wiley   +1 more source

Glutaminase inhibitor CB-839 causes metabolic adjustments in colorectal cancer cells. [PDF]

Sci Rep
Spada M, Piras C, Leoni VP, Casula M, Simbula G, Noto A, Lilliu K, Kopeć KK, Serreli G, Murgia F, Etzi F, Dettori T, Atzori L, Caria P.   +13 more
europepmc   +1 more source

The tumor microenvironment enhances the expression of cssDNA by modulating cell cycle signaling pathways via SKP2. [PDF]

Sci Rep
Shao D, Wang J, Zou K, Chen Y, Zhang P, Song J.   +5 more
europepmc   +1 more source

FAK modulates glioblastoma stem cell energetics via regulation of glycolysis and glutamine oxidation.

Dis Model Mech
Masalmeh RHA, Dawson JC, Garcia VA, Muir MT, Carter RN, Hardingham GE, Davies C, Graham R, von Kriegsheim A, Marques J, Pednekar C, Pollard SM, Carragher NO, Brunton VG, Frame MC.   +14 more
europepmc   +1 more source

High matrix stiffness triggers the YAP-OPA1-TET1/3 loop to drive chemoresistance via enhanced nuclear-mitochondrial communication. [PDF]

iScience
Wu P, Wang S, Hu Z, Zhang H, Lin Y, Li Z, Wu J, Chen Y, Chen Y, Xu Y, Li J, Guan Y.   +11 more
europepmc   +1 more source

Metabolic nanoblockers for synergistic cancer treatment through glutaminase inhibition and sonodynamic therapy. [PDF]

Ultrason Sonochem
Zhao W, Du J, Song Y, Ma Z, Li S, Wei Y, Zhang G.   +6 more
europepmc   +1 more source

Microbiota-host metabolism reprogramming in colorectal cancer: from pathogenesis to precision therapies. [PDF]

Front Oncol
Guo C, Wang C.
europepmc   +1 more source