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Correction to "Mesenchymal Stem Cell-Derived Exosomes Modulate Chondrocyte Glutamine Metabolism to Alleviate Osteoarthritis Progression". [PDF]

Mediators Inflamm
europepmc   +1 more source

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Glutamine

2012
Glutamine (GLN) has been shown to be a key pharmaconutrient in the body's response to stress and injury. It exerts its protective effects via multiple mechanisms, including direct protection of cells and tissue from injury, attenuation inflammation, and preservation of metabolic function.
Mike, Kim, Paul E, Wischmeyer
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Glutamine

World Journal of Surgery, 2000
AbstractRelatively little was known about glutamine metabolism until the 1930s, when Sir Hans Krebs first demonstrated glutamine hydrolysis and biosynthesis in the kidney. Subsequent studies by Rose in 1938 demonstrated that glutamine is a nonessential (dispensable) amino acid, as it can be readily synthesized de novo in virtually all tissues in the ...
B I, Labow, W W, Souba
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The synthesis of glutamine and asparagine peptides and of glutamine

Archives of Biochemistry and Biophysics, 1952
Summary A new synthesis of glutaminylglycine and the synthesis of a new peptide, asparaginylglycine, are reported. The syntheses of glycylglutamine, glycylasparagine, and glutamine have been reinvestigated. A method for the purification of commercial glutamine is proposed.
H K, MILLER, H, WAELSCH
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Congenital Glutamine Deficiency with Glutamine Synthetase Mutations

New England Journal of Medicine, 2005
Glutamine synthetase plays a major role in ammonia detoxification, interorgan nitrogen flux, acid-base homeostasis, and cell signaling. We report on two unrelated newborns who had congenital human glutamine synthetase deficiency with severe brain malformations resulting in multiorgan failure and neonatal death.
Johannes, Häberle, Boris, Görg, Frank, Rutsch, Eva, Schmidt, Annick, Toutain, Jean-François, Benoist, Antoinette, Gelot, Annie-Laure, Suc, Wolfgang, Höhne, Freimut, Schliess, Dieter, Häussinger, Hans G, Koch   +11 more
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The Effect of Glutamine Administration on Intestinal Glutamine Content

Journal of Surgical Research, 1996
The small intestine has been identified as an important site of metabolism of glutamine. The impairment of gut mucosa integrity during total parenteral nutrition (TPN) has been ascribed to a diminished supply of glutamine, due to the lack of glutamine in standard TPN. In addition, nutritional depletion diminishes glutamine availability in the intestine.
van der Hulst, R.R.W.J., von Meyenfeldt, M.F., Deutz, N.E.P., Stockbrügger, R.W., Soeters, P.B.   +4 more
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Response of glutamine metabolism to exogenous glutamine in humans

American Journal of Physiology-Endocrinology and Metabolism, 1995
To determine whether exogenous glutamine affects whole body glutamine metabolism, preliminary experiments were performed to verify that L-[1-13C]-, L-[U-14C]-, and L-[3,4-3H]glutamine given simultaneously by vein provided similar estimates of glutamine appearance rates [Ra; 355 +/- 24, 373 +/- 19, and 393 +/- 24 (SE) mumol.kg-1.h-1, respectively, P ...
R G, Hankard, D, Darmaun, B K, Sager, D, D'Amore, W R, Parsons, M, Haymond   +5 more
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Alanyl-glutamine but not glycyl-glutamine improved the proliferation of enterocytes as glutamine substitution in vitro

Amino Acids, 2017
The synthetic dipeptides alanyl-glutamine (Ala-Gln) and glycyl-glutamine (Gly-Gln) are used as Gln substitution to provide energy source in the gastrointestinal tract due to their high solubility and stability. This study aimed to investigate the effects of Gln, Ala-Gln and Gly-Gln on mitochondrial respiration and protein turnover of enterocytes ...
Bie Tan, Honglan Liu, Guangzu He, Hao Xiao, Dingfu Xiao, Yanhong Liu, Jianping Wu, Jun Fang, Yulong Yin   +8 more
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