Results 181 to 190 of about 200,780 (234)

Glutamine synthetase activity and glutamine content in brain: modulation by NMDA receptors and nitric oxide [PDF]

Neurochemistry International, 2003
Acute intoxication with large doses of ammonia leads to rapid death. The main mechanism for ammonia elimination in brain is its reaction with glutamate to form glutamine. This reaction is catalyzed by glutamine synthetase and consumes ATP.
Regina Rodrigo, Elena Kosenko, Carmina Montoliu   +2 more
exaly   +2 more sources

Glutamine synthetase: glial localization in brain [PDF]

Science, 1977
Light microscopy immunohistochemical techniques were used to examine the distribution of glutamine synthetase in rat brain. Glutamine synthetase was found to be localized in the glial cells. Neuronal cell bodies, endothelial cells, and choroid epithelium
A. Martinez‐Hernandez, K. Bell, M. Norenberg   +2 more
semanticscholar   +2 more sources

Reciprocal regulation of glutamine synthetase and carbamoylphosphate synthetase levels in rat liver [PDF]

Biochimica Et Biophysica Acta Gene Regulatory Mechanisms, 1987
In glucocorticosteroid-treated diabetic rats, glutamine synthetase enzyme levels in the liver are decreased 3-fold, whereas carbamoylphosphate synthetase enzyme levels are increased 2.3-fold.
Wouter H Lamers, A F M Moorman, A F Moorman   +2 more
exaly   +2 more sources

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Glutamine synthetase and hepatocellular carcinoma

Clinics and Research in Hepatology and Gastroenterology, 2023
Glutamine synthetase (GS) is an enzyme that converts ammonia and glutamate to glutamine using adenosine triphosphate. GS is expressed in the brain, kidney, and liver tissues under normal physiological conditions. GS is involved in abnormal lipid metabolism of the liver by catalyzing de novo synthesis of glutamine, thereby inducing liver inflammation ...
Jinghua, Jiang, Yiting, Hu, Dazhang, Fang, JianSheng, Luo   +3 more
openaire   +2 more sources

GLUTAMINE SYNTHETASE ISOFORMS IN ALGAE [PDF]

New Phytologist, 1986
The occurrence of glutamine synthetase isoforms in algae, from seven different phyla, has been investigated, using ion‐exchange chromatography. The algae have been classified into three groups according to their glutamine synthetase isoform content.
STEWART, G. R., CHANDLER, G., SUMAR, N., SHAH, N., CASSELTON, P. J.   +4 more
exaly   +2 more sources

Congenital Glutamine Deficiency with Glutamine Synthetase Mutations

New England Journal of Medicine, 2005
Glutamine synthetase plays a major role in ammonia detoxification, interorgan nitrogen flux, acid-base homeostasis, and cell signaling. We report on two unrelated newborns who had congenital human glutamine synthetase deficiency with severe brain malformations resulting in multiorgan failure and neonatal death.
Johannes, Häberle, Boris, Görg, Frank, Rutsch, Eva, Schmidt, Annick, Toutain, Jean-François, Benoist, Antoinette, Gelot, Annie-Laure, Suc, Wolfgang, Höhne, Freimut, Schliess, Dieter, Häussinger, Hans G, Koch   +11 more
openaire   +2 more sources

Localisation of Glutamine Synthetase in Chloroplasts

Nature New Biology, 1973
Glutamine is of considerable importance in plants, as a readily metabolised and translocated intermediate and as a product of ammonia detoxification. Glutamine synthetase carries out the ATP-driven addition of ammonia to glutamate to produce the amide. The source of ATP and information on the metabolic role, for glutamine synthetase may be suggested by
D, O'Neal, K W, Joy
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Glutamine synthetase deadenylylating enzyme

Biochemical and Biophysical Research Communications, 1968
The glutamine synthetase of Escherichiacoli exists in various forms differing from each other by their content of covalently bound adenylyl groups (Shapiro etal., 1967;Wulff etal., 1967). The biosynthetic activity of unadenylylated glutamine synthetase is very much greater with Mg2+ as the activating cation than with Mn2+, and its γ-glutamyl ...
B M, Shapiro, E R, Stadtman
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Induction of glutamine synthetase by cortisol

Biochimica et Biophysica Acta (BBA) - General Subjects, 1968
Abstract A 2-fold increase in the activity of hepatic glutamine synthetase ( L -glutamate: ammonia ligase (ADP), EC 6.3.1.2) was observed following the administration of cortisol to adrenalectomized rats and this response was prevented by actinomycin D.
P N, Raina, F, Rosen
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Distribution of glutamine synthetase and an inverse relationship between glutamine synthetase expression and intramuscular glutamine concentration in the horse

Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2008
Glutamine plays important roles in the interorgan transport of nitrogen, carbon and energy but little is known about glutamine metabolism in the horse. In this study we determined the tissue distribution of glutamine synthetase expression in three Standardbred mares.
Helio C, Manso Filho, Helena Emilia C, Costa, Yanxin, Wang, Kenneth H, McKeever, Malcolm, Watford   +4 more
openaire   +2 more sources