Results 131 to 140 of about 88,346 (287)

Lipid metabolism reprograming by SREBP1‐PCSK9 targeting sensitizes pancreatic cancer to immunochemotherapy

Cancer Communications, EarlyView.
Abstract Background Pancreatic cancer's aberrant lipid metabolism fuels cell growth, invasion, and metastasis, yet its impact on immune surveillance and immunotherapy is unclear. This study investigated how sterol regulatory element‐binding transcription factor 1 (SREBP1)‐driven lipid metabolism affects the tumor microenvironment (TME) in pancreatic ...
Mengyi Lao, Xiaozhen Zhang, Zejun Li, Kang Sun, Hanshen Yang, Sicheng Wang, Lihong He, Yan Chen, Hanjia Zhang, Jiatao Shi, Daqian Xu, Tingbo Liang, Xueli Bai   +12 more
wiley   +1 more source

Ubiquitination in cancer: mechanisms and therapeutic opportunities

Cancer Communications, EarlyView.
Abstract Ubiquitination, a key post‐translational modification, plays an essential role in tumor biology by regulating fundamental cellular processes, such as metabolism and cell death. Additionally, it interacts with other post‐translational modifications, which are closely linked to tumorigenesis, tumor progression, the tumor microenvironment, and ...
Susi Zhu, Xu Zhang, Waner Liu, Zhe Zhou, Siyu Xiong, Jie Li, Xiang Chen, Cong Peng   +7 more
wiley   +1 more source

Genetic polymorphisms in glutathione-S-transferases are associated with anxiety and mood disorders in nicotine dependence

, 2014
Nicotine dependence is associated with an increased risk of mood and anxiety disorders and suicide. The primary hypothesis of this study was to identify whether the polymorphisms of two glutathione-S-transferase enzymes (GSTM1 and GSTT1 genes) predict an
Berk,M, Dodd,S, Ehara Watanabe,MA, Kaminami Morimoto,H, Losi Guembarovski,R, Odebrecht Vargas Nunes,S, Odebrecht Vargas,H, Pizzo de Castro,MR, Reiche,EM   +8 more
core   +1 more source

Antioxidants and Antidiabetic Potential of Polyphenolic Fractions and Crude Extracts of Rhus typhina Fruit, Punica granatum L. Peel, and Terminalia catappa L. Leaves: In Vitro and In Vivo Evaluation

Chemistry &Biodiversity, EarlyView.
This graphical abstract represents the extraction, characterization, and biological evaluation of bioactive compounds derived from specific plant sources. The top section illustrates Rhus coriaria (sumac) fruit, Punica granatum (pomegranate) peel and Terminalia catappa (Indian almond) leaves', which are known for their rich phytochemical composition ...
Mudassir Nazir, Muhammad Abdul Haq, Syed Arsalan Ali, Syed Muhammad Ghufran Saeed, Muhammad Ali Ajmal, Muhammad Nisar, Taseer Ahmed Khan, Alexandros Tsoupras, Shahina Naz   +8 more
wiley   +1 more source

Differential induction of class Alpha glutathione S-transferases in mouse liver by the anticarcinogenic antioxidant butylated hydroxyanisole. Purification and characterization of glutathione S-transferase Ya1Ya1 [PDF]

, 1989
L I McLellan, John D. Hayes
openalex   +1 more source

Galactose‐Functionalized Gold Nanoparticles Targeting Membrane Transporters for the Glutathione Delivery to Brain Cancer Cells

ChemBioChem, EarlyView.
Glutathione‐functionalized gold nanoparticles are shown to reduce radicals in SH‐SY5Y and C6 cells. Conjugation of galactose to the outer shell improves internalization through the GLUT transporter, thus providing a smart multivalent system able to reduce oxidative stress in neuroblastoma and rat glioma cells.
Francesca Milano, Alessia Nito, Annalisa Caputo, Antonio Gaballo, Marco Marradi, Alessandra Quarta, Andrea Ragusa   +6 more
wiley   +1 more source

No contribution of GSTM1 and GSTT1 null genotypes to the risk of neutropenia due to benzene exposure in Southeastern Brazil

Genetics and Molecular Biology, 2009
Exposure to benzene has been associated with haematological diseases such as neutropenia (NEB) and acute myeloid leukaemia (AML). We tested whether the null genotypes of the GSTM1 and GSTT1 genes, involved in benzene inactivation, altered the risk for ...
Carmen Silvia Passos Lima, Gustavo Jacob Lourenço, Irene Lorand-Metze, Helvia Nascimento, Sara Teresinha Ollala Saad, Fernando Ferreira Costa   +5 more
doaj  

Cholic acid binding by glutathione S-transferases from rat liver cytosol [PDF]

, 1980
John D. Hayes, Richard C. Strange, I W Percy-Robb   +2 more
openalex   +1 more source

Cyanophenylalanine as an Infrared Probe for Iron–Sulfur Cluster Redox State in Multicenter Metalloenzymes

ChemBioChem, EarlyView.
The noncanonical amino acid, cyanophenylalanine, is genetically inserted close to iron–sulfur clusters of either spinach ferredoxin or iron–iron hydrogenase, and functions as an infrared spectroscopic reporter for changes in cluster redox state.
Zehui Duan, Jiaao Wei, Stephen B. Carr, Miguel Ramirez, Rhiannon M. Evans, Philip A. Ash, Patricia Rodriguez‐Macia, Amit Sachdeva, Kylie A. Vincent   +8 more
wiley   +1 more source

The presence and longitudinal distribution of the glutathione S-transferase in rat epididymis and vas deferens [PDF]

, 1980
Barbara F. Hales, Christiane Hachey, Bernard Robaire   +2 more
openalex   +1 more source