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Glutathione S-Transferases - A Review
Current Medicinal Chemistry, 1999Abstract: The Glutathione S-transferases (GSTs) form a group of multi-gene isoenzymes involved in the cellular detoxification of both xenobiotic and endobiotic compounds. GSTs have been divided into a number of subclasses, alpha (α), mu {μ), pi (π), and theta (θ).
A E, Salinas, M G, Wong
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Lung, 1984
Glutathione S-transferases play a major role in the protection of tissues from the toxic effects of exnobiotics and the products of lipid peroxidation. In the present studies we demonstrate that human lung has two forms of glutathione (GSH) S-transferase having isoelectric pH of 4.9 and 9.2.
Catherine A. Partridge +2 more
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Glutathione S-transferases play a major role in the protection of tissues from the toxic effects of exnobiotics and the products of lipid peroxidation. In the present studies we demonstrate that human lung has two forms of glutathione (GSH) S-transferase having isoelectric pH of 4.9 and 9.2.
Catherine A. Partridge +2 more
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The glutathione S-transferases of fish
Fish Physiology and Biochemistry, 1987Substantial soluble glutathione S-transferase activity and millimolar reduced glutathione (GSH) are present in most tissues of both teleosts and elasmobranchs. The hepatic enzymes of fish conjugate a range of electrophilic substrates with GSH, although their specificities are less broad than those of the transferases in rodent liver.
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Drosophila Glutathione S‐Transferases
2005The Drosophila glutathione S-transferases (GSTs; EC2.5.1.18) comprise a host of cytosolic proteins that are encoded by a gene superfamily and a homolog of the human microsomal GST. Biochemical studies of certain recombinant GSTs have linked their enzymatic functions to important substrates such as the pesticide DDT and 4-hydroxynonenal, a reactive ...
Bünyamin Akgül, Chen-Pei D. Tu
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1977
Any symposium which deals with the metabolic formation and inactivation of reactive metabolites must necessarily consider the prominent role played by glutathione (GSH) and the glutathione transferases since this simple tripeptide (Fig. 1) and the enzymes which employ GSH as a cosubstrate represent a very important factor in the protection of cellular ...
John R. Bend, Donald M. Jerina
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Any symposium which deals with the metabolic formation and inactivation of reactive metabolites must necessarily consider the prominent role played by glutathione (GSH) and the glutathione transferases since this simple tripeptide (Fig. 1) and the enzymes which employ GSH as a cosubstrate represent a very important factor in the protection of cellular ...
John R. Bend, Donald M. Jerina
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Glutathione-S-transferase family of enzymes
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2001The loci encoding the glutathione-S-transferase (GST) enzymes comprise a large supergene family located on at least seven chromosomes. The function of the GST enzymes has traditionally been considered to be the detoxication of electrophiles by glutathione conjugation. A wide variety of endogenous (e.g.
Anthony A. Fryer +3 more
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Human genes for glutathione S-transferases
Human Genetics, 1984The tissue distribution of different glutathione S-transferases (GST) is analysed by electrophoresis. The existence of GST"e" (erythrocyte), GST3, GST1, and GST2 is confirmed. GST"e" the fastest and most thermolabile of different GST analysed is observed only in erythrocyte cells.
Nguyen Van Cong +3 more
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Low glutathione S -transferase dogs
Archives of Toxicology, 2004Liver and kidney glutathione S-transferase (GST) activities to 1,2-dichloro-4-nitrobenzene (DCNB) as a substrate (GST-D activities) were measured in 280 dogs from five different breeders, and significant individual differences in this activity were observed in both organs. Interestingly, 34 out of the 280 dogs (i.e. 12.1%) were those in which liver GST-
Toshiyuki Watanabe +4 more
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Glutathione S-transferases in esophageal cancer
Carcinogenesis, 1993Glutathione content and glutathione S-transferase enzyme activity as well as isoenzyme composition were studied in normal gastric cardia, normal squamous esophageal epithelium and corresponding malignant tumor of 10 patients with esophageal cancer. Mean values of glutathione (38 +/- 6 versus 36 +/- 12 nmol/mg protein) and glutathione S-transferase ...
Hennie M.J. Roelofs +3 more
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Binding of acrylamide with glutathione-S-transferases
Chemico-Biological Interactions, 1980Introduct ion GST, a family of cytosolic enzymes, plays an important role in cellular biotransformation and elimination of toxic electrophiles by glutathione conjugation and subsequent excretion as mereapturic acid [1,2]. GST bind a broad range of substrate and non~substrate ligands and subsequently function both as catalytic proteins for cellular ...
C.R. Krishna Murti +3 more
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