Results 111 to 120 of about 986,817 (390)

Cytoprotective effects of melatonin against amitriptyline-induced toxicity in isolated rat hepatocytes [PDF]

, 2015
Purpose: Amitriptyline, one of the commonly used tricyclic antidepressants, caused rare but severe hepatotoxicity in patients who received it continuously. Previous findings showed that the intermediate metabolites of amitriptyline produced by CYP450 are
Dastmalchi, S., Eghbal, M.A., Sattari, M.R., Taziki, S.   +3 more
core   +1 more source

Unraveling the Potential Role of Glutathione in Multiple Forms of Cell Death in Cancer Therapy

Oxidative Medicine and Cellular Longevity, 2019
Glutathione is the principal intracellular antioxidant buffer against oxidative stress and mainly exists in the forms of reduced glutathione (GSH) and oxidized glutathione (GSSG).
Huanhuan Lv, Chen-xiao Zhen, Jun-yu Liu, Pengfei Yang, Lijiang Hu, P. Shang   +5 more
semanticscholar   +1 more source

Doxorubicin‐Loaded Metal–Organic Framework for Ferroptosis‐Enhanced Chemotherapy Through Sustained Zn Release and Glutathione Peroxidase Downregulation

Advanced Healthcare Materials, EarlyView.
A robust zinc‐based metal–organic framework (ZnMOF) enables dual functions of doxorubicin delivery and sustained Zn2+ release to trigger ferroptosis‐enhnaced chemotherapy. DOX@ZnMOF effectively depletes intracellular glutathione, suppresses GPX4, and elevates reactive oxygen species, leading to efficient oxidative DNA damage and apoptosis.
Xin Ma, Chenghua Deng, Chaoyu Wang, Langston Tilman, Jinhong Li, Wenbin Lin   +5 more
wiley   +1 more source

Effect of cadmium stress on the content of phytochelatins in Salix variegata

浙江大学学报. 农业与生命科学版, 2017
With rapid development of industrialization and urbanization in China, large amounts of heavy metals have been directly or indirectly released into the soil environment through solid wastes, waste air, and waste water from industrial activities over the ...
LIU Yuan, WANG Niya, ZHANG Wen, YU Jia, WEI Hong   +4 more
doaj   +1 more source

Synergistic effect of glutathione and IgG4 in immune evasion and the implication for cancer immunotherapy

, 2023
Weifeng Zhang, Yan Quan, Xiaonan Ma, Liting Zeng, Jirui Li, Shuqi Chen, Meng Su, Liangli Hong, Penghao Li, Hui Wang, Qian Xu, Chanyuan Zhao, Xiaoqing Zhu, Yiqun Geng, Xiaomiao Yan, Fang Zheng, Mu‐Wang Chen, Dongping Tian, Min Su, Xueling Chen, Jiang Gu   +20 more
openalex   +1 more source

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

Advanced Healthcare Materials, EarlyView.
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner, Stefan Keim, Soheil Haddadzadegan, Odile Fernandez Romero, Katrin Zöller, Gabriel Stern, Ilaria Cesi, Krum Kafedjiiski, Andreas Bernkop‐Schnürch   +8 more
wiley   +1 more source

Photosensitizing Lipid Nanoparticles for Ferroptosis‐Enhanced Photodynamic Cancer Therapy via GPX4 Silencing

Advanced Healthcare Materials, EarlyView.
Photosensitizing lipid nanoparticles (PLNPs) are engineered by incorporating cholesterol–PEG–pheophorbide a into MC3‐based LNPs and encapsulating GPX4‐targeting siRNA. Upon light activation, PLNPs generate reactive oxygen species (ROS) while silencing GPX4 to induce ferroptosis.
Ga‐Hyun Bae, Seungyong Shin, Joo Dong Park, Eun‐Young Koh, Seunghyo Ko, Jieun Han, Chun Gown Park, Dong‐Hyun Kim, Kun Na, Wooram Park   +9 more
wiley   +1 more source

Redox linked flavin sites in extracellular decaheme proteins involved in microbe-mineral electron transfer [PDF]

, 2015
Extracellular microbe-mineral electron transfer is a major driving force for the oxidation of organic carbon in many subsurface environments. Extracellular multi-heme cytochromes of the Shewenella genus play a major role in this process but the mechanism
A Okamoto, AC Mitchell, AGW Leslie, AM Waterhouse, AS Beliaev, CL Reardon, D Coursolle, D Ghosal, DE Ross, DJ Richardson, DJ Richardson, DJ Richardson, DK Thompson, E Marsili, ED Brutinel, F Sievers, GF White, GM Boratyn, GN Murshudov, I Letunic, JK Fredrickson, L Shi, L Shi, MJ Daly, MJ Daly, MJ Edwards, MJ Edwards, MJ Edwards, MY El-Naggar, P Taylor, PD Adams, RJ Morris, RS Hartshorne, S Bailey, S Pirbadian, TA Clarke   +35 more
core   +1 more source

Catalase, superoxide dismutase and ascorbate-glutathione cycle enzymes confer drought tolerance of Amaranthus tricolor

Scientific Reports, 2018
The study was performed to explore physiological, non-enzymatic and enzymatic detoxification pathways of reactive oxygen species (ROS) in tolerance of Amaranthus tricolor under drought stress.
Umakanta Sarker, S. Oba
semanticscholar   +1 more source

Targeting the ARRDC3–DRP1 Axis via hUMSC‐Derived Exosomal CRYAB for Neuroprotection in Cerebral Ischemia/Reperfusion Injury

Advanced Healthcare Materials, EarlyView.
Intranasally administered hUMSC‐derived exosomes modulate the CRYAB–ARRDC3–Drp1 axis, alleviating mitochondrial dysfunction and ferroptosis, enhancing neuronal survival, reducing oxidative stress, and promoting functional recovery in ischemia‐reperfusion injury, offering a promising therapeutic strategy for ischemic stroke.
Rong ji, Zengyu Zhang, Zhuohang Liu, Kaicheng Yang, Xueyu Mao, Min Chu, Yong Wang, Jing Zhao   +7 more
wiley   +1 more source