Results 291 to 300 of about 618,316 (340)

Simultaneous Fenton-like Ion Delivery and Glutathione Depletion by MnO2 -Based Nanoagent to Enhance Chemodynamic Therapy.

Angewandte Chemie, 2018
Chemodynamic therapy (CDT) utilizes iron-initiated Fenton chemistry to destroy tumor cells by converting endogenous H2 O2 into the highly toxic hydroxyl radical (. OH). There is a paucity of Fenton-like metal-based CDT agents.
Li-sen Lin, Jibin Song, Liang Song, Kaimei Ke, Yijing Liu, Zijian Zhou, Zheyu Shen, Juan Li, Zhen Yang, Wei Tang, G. Niu, Huang-Hao Yang, Xiaoyuan Chen   +12 more
semanticscholar   +1 more source

Transport of glutathione and glutathione conjugates by MRP1

Trends in Pharmacological Sciences, 2006
Glutathione (GSH)-conjugated xenobiotics and GSH-conjugated metabolites (e.g. the cysteinyl leukotriene C4) must be exported from the cells in which they are formed before they can be eliminated from the body or act on their cellular targets. This efflux is often mediated by the multidrug resistance protein 1 (MRP1) transporter, which also confers drug
Susan P.C. Cole, Roger G. Deeley
openaire   +2 more sources

Measurement of Glutathione and Glutathione Disulfide

Current Protocols in Toxicology, 1999
AbstractMeasurements of glutathione should include quantification of both the reduced and oxidized forms. HPLC‐based assays for glutathione and other cellular thiols and disulfides utilize a variety of detection methods, including ultraviolet, fluorescence, and electrochemical methods.
openaire   +3 more sources

Reactions of glutathione and glutathione radicals with benzoquinones

Free Radical Biology and Medicine, 1992
The reactions of glutathione (GSH) and glutathione radicals with a series of methyl-substituted 1,4-benzoquinones and 1,4-benzoquinone have been studied. It was found that by mixing excess benzoquinone with glutathione at pH above 6.5, the products formed were complex and unstable. All of the other experiments were carried out at pH 6.0, where the main
Brigid M Hoey, John Butler
openaire   +3 more sources

Glutathione

2015
Glutathione is an endogenous peptide with antioxidant and other metabolic functions. The nomenclature, formulae, elemental composition, and appearance and uses of the drug are included. The methods used for the synthesis and biosynthesis of glutathione are described.
Abdullah A. Al-Badr, Amer M. Alanazi, Gamal A. E. Mostafa   +2 more
openaire   +3 more sources

Self-Assembled Copper-Amino Acid Nanoparticles for in Situ Glutathione "AND" H2O2 Sequentially Triggered Chemodynamic Therapy.

Journal of the American Chemical Society, 2018
Nanoformulations that can respond to the specific tumor microenvironment (TME), such as a weakly acidic pH, low oxygen, and high glutathione (GSH), show promise for killing cancer cells with minimal invasiveness and high specificity.
Baojin Ma, Shu Wang, Feng Liu, Shan Zhang, Jiazhi Duan, Z. Li, Ying Kong, Y. Sang, Hong Liu, Wenbo Bu, Linlin Li   +10 more
semanticscholar   +1 more source

Glutathione and glutathione analogues; Therapeutic potentials

Biochimica et Biophysica Acta (BBA) - General Subjects, 2013
Glutathione (GSH) and related enzymes are critical to cell protection from toxins, both endogenous and environmental, including a number of anti-cancer cytotoxic agents.Enhancing GSH and associated enzymes represents a longtime and persistent aim in the search for cytoprotective strategies against cancer, neurologic degeneration, pulmonary and ...
Jian Hui Wu, Gerald Batist
openaire   +3 more sources

Inhibition of glutathione disulfide reductase by glutathione

Archives of Biochemistry and Biophysics, 1991
Rat-liver glutathione disulfide reductase is significantly inhibited by physiological concentrations of the product, glutathione. GSH is a noncompetitive inhibitor against GSSG and an uncompetitive inhibitor against NADPH at saturating concentrations of the fixed substrate.
Hiram F. Gilbert, Roseann E. Cappel, Phyllis M. Chung   +2 more
openaire   +3 more sources

Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite.

Pharmacology, 1974
This laboratory has previously postulated that bromobenzene-induced hepatic necrosis results from the formation of a reactive metabolite that arylates vital cellular macromolecules.
D. Jollow, J. Mitchell, N. Zampaglione, J. Gillette   +3 more
semanticscholar   +1 more source

Glutathione and glutathione-related enzymes in reproduction

European Journal of Obstetrics & Gynecology and Reproductive Biology, 1999
Glutathione and glutathione-related enzymes are pivotal for the normal functioning of several important biological processes in humans. Glutathione and glutathione-related enzymes are involved in the metabolism and detoxification of cytotoxic and carcinogenic compounds as well as reactive oxygen species.
Knapen, M.F.C.M., Zusterzeel, P.L.M., Peters, W.H.M., Steegers, E.A.P.   +3 more
openaire   +4 more sources