Results 301 to 310 of about 775,294 (358)
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[Glutathione and glutathione assays].
Acta medica (Hradec Kralove). Supplementum, 2006Glutathione, the very important intracellular antioxidant, is present in intracelullar environment in milimolar concentrations. Glutathione is a tripeptide molecule, which plays an essential role in the antioxidant system, as well as in maintenance of the intracellular redox state.
Tomás, Rousar +5 more
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Detoxication reactions of glutathione and glutathione transferases
Xenobiotica, 1986(1986). Detoxication reactions of glutathione and glutathione transferases. Xenobiotica: Vol. 16, No. 10-11, pp. 957-973.
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Glutathione and detoxification
Cancer Treatment Reviews, 1990Cisplatin is recognized as one of the most effective drugs in the treatment of a variety of solid tumors. Its therapeutic usefulness has been limited by acute and cumulative nephrotoxicity ( 13). This side-effect is dose-dependent and requires adequate protective measures.
M, Tedeschi +6 more
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Biochemistry (Moscow), 2007
Many functions of mitochondrial GSH are significantly different from those of cytosolic GSH. This review considers the peculiarity of functions of mitochondrial GSH and enzymes of its metabolism, especially glutathione peroxidase 4, glutaredoxin 2, and kappa-glutathione transferase.
V I, Kulinsky, L S, Kolesnichenko
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Many functions of mitochondrial GSH are significantly different from those of cytosolic GSH. This review considers the peculiarity of functions of mitochondrial GSH and enzymes of its metabolism, especially glutathione peroxidase 4, glutaredoxin 2, and kappa-glutathione transferase.
V I, Kulinsky, L S, Kolesnichenko
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Biochimica et Biophysica Acta (BBA) - General Subjects, 2013
Glutathione (GSH) is a linchpin of cellular defences in plants and animals with physiologically-important roles in the protection of cells from biotic and abiotic stresses. Moreover, glutathione participates in numerous metabolic and cell signalling processes including protein synthesis and amino acid transport, DNA repair and the control of cell ...
José Luis, García-Giménez +6 more
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Glutathione (GSH) is a linchpin of cellular defences in plants and animals with physiologically-important roles in the protection of cells from biotic and abiotic stresses. Moreover, glutathione participates in numerous metabolic and cell signalling processes including protein synthesis and amino acid transport, DNA repair and the control of cell ...
José Luis, García-Giménez +6 more
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Biochimica et Biophysica Acta (BBA) - General Subjects, 2013
The tripeptide γ-glutamylcysteinylglycine or glutathione (GSH) has demonstrated protective abilities against the detrimental effects of oxidative stress within the human body, as well as protection against infection by exogenous microbial organisms.In this review we describe how GSH works to modulate the behavior of many cells including the cells of ...
Devin, Morris +8 more
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The tripeptide γ-glutamylcysteinylglycine or glutathione (GSH) has demonstrated protective abilities against the detrimental effects of oxidative stress within the human body, as well as protection against infection by exogenous microbial organisms.In this review we describe how GSH works to modulate the behavior of many cells including the cells of ...
Devin, Morris +8 more
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Regulatory Phenomena in the Glutathione Peroxidase Superfamily
Antioxidants and Redox Signaling, 2019Significance: The selenium-containing Glutathione peroxidases (GPxs)1–4 protect against oxidative challenge, inhibit inflammation and oxidant-induced regulated cell death.
R. Brigelius-Flohé, L. Flohé
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American Journal of Therapeutics, 2002
A growing body of evidence indicates that glutathione (GSH) plays a vitally important role in cellular function. It detoxifies toxic metabolites of drugs and reactive oxygen species and regulates gene expression, apoptosis, and transmembrane transport of organic solutes.
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A growing body of evidence indicates that glutathione (GSH) plays a vitally important role in cellular function. It detoxifies toxic metabolites of drugs and reactive oxygen species and regulates gene expression, apoptosis, and transmembrane transport of organic solutes.
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Current Opinion in Clinical Nutrition and Metabolic Care, 2001
Altered glutathione metabolism in association with increased oxidative stress has been implicated in the pathogenesis of many diseases. However, whether strategies aimed at restoring glutathione concentration and homeostasis are effective in ameliorating or modifying the natural history of these states is unknown.
M, Reid, F, Jahoor
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Altered glutathione metabolism in association with increased oxidative stress has been implicated in the pathogenesis of many diseases. However, whether strategies aimed at restoring glutathione concentration and homeostasis are effective in ameliorating or modifying the natural history of these states is unknown.
M, Reid, F, Jahoor
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Cellular and Molecular Life Sciences, 2001
There are several proteins in mammalian cells that can metabolize hydrogen peroxide and lipid hydroperoxides. These proteins include four selenium-containing glutathione peroxidases that are found in different cell fractions and tissues of the body. This review considers the structure and distribution of the selenoperoxidases and how this relates to ...
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There are several proteins in mammalian cells that can metabolize hydrogen peroxide and lipid hydroperoxides. These proteins include four selenium-containing glutathione peroxidases that are found in different cell fractions and tissues of the body. This review considers the structure and distribution of the selenoperoxidases and how this relates to ...
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