Results 141 to 150 of about 53,702 (285)

Disulfide-Mediated Bioconjugation: Disulfide Formation and Restructuring on the Surface of Nanomanufactured (Microfluidics) Nanoparticles

, 2019
This study is about (1) nanomanufacturing (focusing on microfluidic-assisted nanoprecipitation), (2) advanced colloid characterization (focusing on field flow fractionation), and (3) the possible restructuring of surface disulfides.
Benedetto Grimaldi, Arianna Gennari (3932471), Nicola Tirelli (1477183), Mike Geven (1836955), Donghun Koo, Roberto Donno (3752566), Arianna Gennari, Hanying Luo (2619412), Roberto Donno, Nicola Tirelli, Mike Geven, Gangadhar Panambur (6997640), Donghun Koo (6997637), Roberto Marotta (445587), Gangadhar Panambur, Hanying Luo, Benedetto Grimaldi (691553), Roberto Marotta   +17 more
core   +1 more source

S100A9 promotes pulmonary arterial hypertension by regulating mitochondria–endoplasmic reticulum interaction‐mediated inflammatory injury of endothelial cells

Interdisciplinary Medicine, EarlyView.
Macrophage‐derived S100 calcium‐binding protein A9 (S100A9) promotes the pathological progression of pulmonary arterial hypertension (PAH). S100A9 upregulates the interaction between signal‐transducing adaptor protein 2 and leucine‐rich repeat kinase 2, thereby regulating mitochondria–endoplasmic reticulum (ER) contact.
Chen Gong, Long Chen, Yiting Zhao, Xiaohe Wang, Qiang Yuan, Xiaofeng Fang, Liuyi Li, Yinbo Xu, Shumei Jiang, Guangwen Xu, Ke Meng, Delong Wang, Kangli Cao, Jianlong Sheng, Liling Guo, Shichun Shen   +15 more
wiley   +1 more source

Bioinorganic Site‐Specific Conjugation of Multi‐Arm Linkers to Create Pharmaceuticals With Targeting and Effector Functions

Journal of the Chinese Chemical Society, EarlyView.
This Account showcases a modular, multi‐arm linker platform that decouples payload loading from antibody conjugation. By leveraging a computationally designed ACPGHA zinc‐binding motif, we demonstrate the construction of homogeneous antibody‐drug conjugates and theranostic antibody‐radionuclide conjugates with high payload loading. The multi‐arm linker
Cédric Grauffel, Tse Wen Chang, Carmay Lim   +2 more
wiley   +1 more source

Understanding polysulfide evolution in wine: insights from accelerated ageing and real-time cellaring in different packaging

Food Chemistry: X
Volatile sulfur compounds (VSCs) and non-volatile biothiols play a crucial role in wine quality. Certain sulfhydryl compounds can react to form odourless polysulfides (RSSnSR′) that potentially contribute to the development of sulfur off-odours during ...
Yu Hou, Marlize Z. Bekker, Tracey E. Siebert, Gal Y. Kreitman, David W. Jeffery   +4 more
doaj   +1 more source

Binuclear Copper‐Dependent Oxidative Enzymes Involved in Fungal Natural Product Modifications

Journal of the Chinese Chemical Society, EarlyView.
This article summarizes recent biochemical characterizations of a new enzyme family named by the authors as binuclear copper‐dependent oxidative enzymes (BiNCOs). Found in fungal natural product biosynthesis, BiNCOs catalyze diverse CH functionalization reactions, including C(sp3)H halogenation, C(sp3)H hydroxylation, C(sp3)O macrocyclization, and ...
Chen‐Yu Chiang, Masao Ohashi, Yi Tang
wiley   +1 more source

Redox-manipulating nanocarriers for anticancer drug delivery: a systematic review

Journal of Nanobiotechnology
Spatiotemporally controlled cargo release is a key advantage of nanocarriers in anti-tumor therapy. Various external or internal stimuli-responsive nanomedicines have been reported for their ability to increase drug levels at the diseased site and ...
Xuan Meng, Yongli Shen, Huanyu Zhao, Xinlei Lu, Zheng Wang, Yanjun Zhao   +5 more
doaj   +1 more source

Bromelain as the enzyme of the future: A global bibliometric mapping of its applications and emerging trends

Journal of the Science of Food and Agriculture, EarlyView.
Abstract INTRODUCTION Bromelain, a complex mixture of proteolytic enzymes primarily extracted from plants of the Bromeliaceae family, has gained prominence because of its broad industrial applicability, particularly in the food, pharmaceutical and cosmetic sectors.
Genésio José da Silva Neto, Tonny Cley Campos Leite, Mônica Tejo Cavalcanti, Geany Targino Sousa Pedrosa, Rerisson do Nascimento Alves, Amanda Reges de Sena, Mônica Correia Gonçalves   +6 more
wiley   +1 more source

Analysis of Glutathione, Glutathione Disulfide, Cysteine, Homocysteine, and Other Biological Thiols by High-performance Liquid Chromatography Following Derivatization by N-(1-pyrenyl)maleimide

, 1995
The compound N-(1-pyrenyl)maleimide (NPM) reacts with free sulfhydryl groups to form fluorescent derivatives. A new method for measurement of glutathione and other biological thiols utilizing reverse-phase high-performance liquid chromatography to ...
Zukowski, Janusz, Spitz, Douglas R., Ercal, Nuran, Mathews, Richard H., Winters, Roger A.   +4 more
core   +1 more source

ZFP36L1 Enhances Microglial Ferroptosis in Ischemic Stroke by Reducing FTO‐Mediated N6‐Methyladenosine Demethylation of ACSL1 mRNA

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Microglia play an important role in ischemic stroke (IS). However, the molecular regulatory mechanisms underlying microglial ferroptosis in IS remain incompletely understood. In this study, blood samples were collected from 20 IS patients and 15 healthy volunteers.
Ai‐Xia Song, Han‐Xu Jin, Yuan‐Xin Sun, Wen‐Hui Kou, Xiao‐Ning Niu, Huan‐Huan Wang, Ting‐Ting Zhong, Ping Gu   +7 more
wiley   +1 more source

GSH-responsive degradable nanodrug for glucose metabolism intervention and induction of ferroptosis to enhance magnetothermal anti-tumor therapy

Journal of Nanobiotechnology
The challenges associated with activating ferroptosis for cancer therapy primarily arise from obstacles related to redox and iron homeostasis, which hinder the susceptibility of tumor cells to ferroptosis.
Zhen Liao, E. Wen, Yi Feng
doaj   +1 more source