Results 211 to 220 of about 48,461 (279)

An Overview of Liquid Chromatography–Mass Spectrometry (LC–MS) Methods for the Quantification of Antibody‐Drug Conjugates

Biomedical Chromatography, Volume 40, Issue 2, February 2026.
ABSTRACT Antibody‐drug conjugates (ADCs) are innovative drugs composed of cytotoxic molecules (payload) linked to antibodies, that selectively target and kill cancer cells upon internalization. In vivo, ADCs exist as intact molecules, naked antibodies, or released, unconjugated (linker‐)payload.
Pauline L. M. Buitelaar, Hilde Rosing, Jos H. Beijnen, Neeltje Steeghs, Alwin D. R. Huitema   +4 more
wiley   +1 more source

A roadmap to chemically reactive species: how diverse oxidants affect <i>Candida albican</i><i>s</i> and other fungi. [PDF]

Microbiol Mol Biol Rev
Swenson KA, Alberti L, Teele K, Yadav A, Shah SJ, Konopka JB.   +5 more
europepmc   +1 more source

New Insights on Heat Shock Proteins as Regulators of Reactive Oxygen Species Across Various Stressors in Diseases

Cell Biochemistry and Function, Volume 44, Issue 2, February 2026.
ABSTRACT Living beings are persistently challenged by stress. Stress can be induced by internal stressors and external stressors. External stressors, including radiation, heat, heavy metals, nutritional imbalances, infections, and psychological stress, can induce protein denaturation, leading to misfolded or aggregated proteins.
Paka Sravan Kumar, Triveni Kodi, Adarsh Gopinathan, Bharath Harohalli Byregowda, Krishnadas Nandakumar, Anoop Kishore   +5 more
wiley   +1 more source

Label-Free Detection of Glutathione and Glutathione Disulfide in Biological Fluid by Using an Alpha-Hederin Nanopore

Sang-Mook You, Ki‐Baek Jeong, Dong-Gook Kang, Sang Min Kim, Young‐Rok Kim   +4 more
openalex   +1 more source

Molecular Mechanisms and Therapeutic Potential of DJ‐1 in Skeletal Muscle Homeostasis and Disease

Comprehensive Physiology, Volume 16, Issue 1, February 2026.
DJ‐1 protein functions as a redox‐sensing guardian in skeletal muscle by coordinating antioxidant defense, mitochondrial homeostasis, metabolic adaptation, and anti‐atrophy signaling. Enhancing its function holds promise as a potential therapeutic strategy for muscle atrophy, ALS, and metabolic myopathies.
Yue Zhang, Menghuan Li, Xiaojing Xie, Baokai Tian, Zhenwei Bao, Xuejie Yi   +5 more
wiley   +1 more source

Glutathione-responsive folic acid modified fluorescent SBA-15 nanocarrier for simultaneous imaging and drug delivery in prostate cancer treatment. [PDF]

J Mater Sci Mater Med
Mahani M, Fallahi Nezhad F, Khakbaz F, Divsar F.   +3 more
europepmc   +1 more source

Hypercapnia Effects on Lung Function

Comprehensive Physiology, Volume 16, Issue 1, February 2026.
CO2 is a signaling molecule that disrupts alveolar fluid clearance and ion transport, impairs alveolar repair, and promotes mitochondrial and endoplasmic reticulum dysfunction. It suppresses innate immunity, host defense, and inflammation, while increasing airway contractility.
Seungseo Choi, Laura A. Dada, Jacob I. Sznajder   +2 more
wiley   +1 more source

Nanomedical approaches to deplete intracellular glutathione in oncology. [PDF]

Chem Sci
Bonet-Aleta J, Hueso JL, Mosseri A, Santamaria J.   +3 more
europepmc   +1 more source

Alpha‐Lipoic Acid Reduces NLRP3/ASC Expression and IL‐1β Release in Kupffer Cells and Improves Insulin Signaling in FL83B Hepatocytes Exposed to a Conditioned Medium

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Alpha‐lipoic acid (ALA) reduced NLRP3/ASC expression, attenuated upstream NF‐κB/ERK signaling, and decreased IL‐1β release while preserving mitochondrial membrane potential in murine Kupffer cells subjected to LPS priming and a second signal. Conditioned medium from ALA‐pretreated Kupffer cells (particularly 100 μM) enhanced glucose uptake and improved
Chih‐Yuan Ko, Yangming Martin Lo, Thi Kim Ngan Nguyen, Shao‐Ting Kao, Chung‐Hsin Wu, Wen‐Chung Huang, Szu‐Chuan Shen   +6 more
wiley   +1 more source

Dynamic Gelatin Hydrogels Crosslinked by Dithiolane‐Norbornene Click Chemistry

Macromolecular Bioscience, Volume 26, Issue 2, February 2026.
Gelatin‐norbornene (GelNB) and poly(ethylene glycol)‐tetra‐lipoic acid (PEG4LA) are modularly photo‐crosslinked into gelatin‐based hydrogels with dynamically tunable mechanics for expansion and differentiation of induced pluripotent stem cells (iPSC). ABSTRACT Hydrogels prepared from gelatin are ideal for mimicking the extracellular matrix (ECM) owing ...
Favour O. Afolabi, Lydia Yang He, Chien‐Chi Lin   +2 more
wiley   +1 more source