Results 261 to 270 of about 77,313 (353)

SQSTM1/p62 Orchestrates Skin Aging via USP7 Degradation

open access: yesAging Cell, EarlyView.
p62 exhibits diminished expression in aging skin and senescent cells. p62 serves to inhibit the accumulation of USP7 during senescence induction. The Tyr‐67 residue within the PB1 domain or Gln‐418 within the UBA domain of p62 forms a hydrogen bond with Ala‐993 of the Ubl5 domain of USP7.
Liu Chen   +10 more
wiley   +1 more source

Disulfidptosis in tumor progression. [PDF]

open access: yesCell Death Discov
Wan S   +10 more
europepmc   +1 more source

Non‐canonical nitric oxide signalling and DNA methylation: Inflammation induced epigenetic alterations and potential drug targets

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract DNA methylation controls DNA accessibility to transcription factors and other regulatory proteins, thereby affecting gene expression and hence cellular identity and function. As epigenetic modifications control the transcriptome, epigenetic dysfunction is strongly associated with pathological conditions and ageing.
Christopher H. Switzer
wiley   +1 more source

Towards precision medicine using biochemically triggered cleavable conjugation. [PDF]

open access: yesCommun Chem
Parshad B   +6 more
europepmc   +1 more source

Supersulfide metabolome of exhaled breath condensate applied as diagnostic biomarkers for esophageal cancer

open access: yesCancer Science, Volume 116, Issue 4, Page 1023-1033, April 2025.
This study evaluated the potential of sulfur metabolites as biomarkers for esophageal cancer using blood and exhaled breath condensate (EBC) samples. Absolute quantification analysis revealed elevated levels of cysteine hydropersulfide (CysSSH) and homocysteine hydropersulfide (HomoCysSSH) in patients with esophageal cancer, with HomoCysSSH in plasma ...
Seji Asamitsu   +13 more
wiley   +1 more source

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