Results 141 to 150 of about 508,182 (337)

Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration

Redox Biology, 2017
W. S. Hambright, R. S. Fonseca, Liuji Chen, Ren Na, Qitao Ran   +4 more
semanticscholar   +1 more source

TP53BP2 Promotes Placental Autophagy and Preeclampsia via G9a and DNMT1 Cooperatively Modulating E2F1

Advanced Science, EarlyView.
G9a, and DNA Methyltransferase1 (DNMT1) cooperatively modulates E2F1 on the promoter of tumor suppressor p53‐binding protein 2 (TP53BP2) increased autophagy in preeclampsia. TP53BP2 promotes autophagy in trophoblasts through DNA methylation and H3K9me2‐mediated transcriptional regulation.
Nan Jiang, Shaoju Jin, Shaoying Wen, Wen Zeng, Chen Wang, Jingyu Wang, Qingyun Song, Guizhong Li, Pengzhi Yin, Yuhui Liao, Yuee Chai, Huiping Zhang, Shengchao Ma   +12 more
wiley   +1 more source

The Regulatory Role of Iron Transporter SLC39A13 in Liver Fibrosis

Advanced Science, EarlyView.
SLC39A13/ZIP13, a newly discovered intracellular iron transporter, delivers iron to the ER/Golgi to catalyze procollagen hydroxylation during collagen maturation. Here, we systematically characterize the cell type‐specific functions of ZIP13 across distinct hepatic cell populations, and identify hepatic stellate cell‐specific ZIP13 as a promising and ...
Shanshan Guo, Yalin Wang, Binyu Lu, Yu Zhang, David M. Frazer, Bing Zhou   +5 more
wiley   +1 more source

Enhanced protocol for measuring glutathione peroxidase activity using a new glutathione peroxidase-Tiron assay. [PDF]

Biol Methods Protoc
Hadwan MH, Mohammed AA, Najavand S, Altaee R, Hadwan AM.   +4 more
europepmc   +1 more source

Glutathione peroxidase 4: a new player in neurodegeneration?

Molecular Psychiatry, 2017
Bárbara Rita Cardoso, Dominic J. Hare, Dominic J. Hare, Ashley I Bush, Blaine R. Roberts   +4 more
semanticscholar   +1 more source

CRISPLD2 Attenuates Intervertebral Disc Degeneration by Suppressing Oxidative Stress‐Induced Ferroptosis through the miR‐548I‐IL17A Axis

Advanced Science, EarlyView.
This study identifies CRISPLD2 as a key protector against IVDD. By regulating ferroptosis through the CRISPLD2–miR‐548I–IL17A axis, CRISPLD2 maintains NPCs homeostasis and reduces oxidative stress. Restoring CRISPLD2 expression effectively alleviates disc degeneration and highlights a promising therapeutic strategy for discogenic low back pain ...
Yangyang Shi, Fudong Li, Tianyi Zhao, Kaiqiang Sun, Danying Zhang, Chen Yan, Ximing Xu, Jingchuang Sun, Xulin Hu, Xin Yong, Jiangang Shi, Yuan Wang   +11 more
wiley   +1 more source

Erythrocyte glutathione peroxidase (GSH-Px) polymorphism in Finnsheep

Genetics Selection Evolution, 1982
Sandholm M, Oeterberg S, Sankari S, Atroshi F   +3 more
doaj   +1 more source

Glutathione peroxidase 8 negatively regulates caspase‐4/11 to protect against colitis

, 2019
Jye‐Lin Hsu, Jen‐Wei Chou, Tzu‐Fan Chen, Jeh‐Ting Hsu, Fang‐Yi Su, Joung‐Liang Lan, Po‐Chang Wu, Chun‐Mei Hu, Eva Y‐HP Lee, Wen‐Hwa Lee   +9 more
openalex   +1 more source

Functional Variants in the Glutathione Peroxidase-1 (GPx-1) Gene Are Associated With Increased Intima-Media Thickness of Carotid Arteries and Risk of Macrovascular Diseases in Japanese Type 2 Diabetic Patients [PDF]

, 2004
Tohru Hamanishi, Hiroto Furuta, Hisako Kato, Asako Doi, M Tamai, Hiroko Shimomura, Setsuya Sakagashira, Masahiro Nishi, Hideyuki Sasaki, Tokio Sanke, Kishio Nanjo   +10 more
openalex   +1 more source

Targeting the GPX4–FUNDC1 Interaction with Magnesium Lithospermate B Attenuates Sepsis‐Associated Lung Injury

Advanced Science, EarlyView.
The diagram depicts the endothelial‐protective mechanism of magnesium lithospermate B (MLB) in sepsis‐associated lung injury. MLB binds GPX4 at Gly79, disrupts its interaction with FUNDC1, prevents mitophagy‐mediated GPX4 degradation, restores mitophagic flux, reduces ROS, and limits ferroptosis.
Zhixi Li, Chang Liu, Zhaoxue Ma, Dongyou Zheng, Renkai Wang, Yongjing Yu, Guangmin Chen, Chenglong Li, Yue Bu, Hang Cao, Bing Zhang   +10 more
wiley   +1 more source