Results 151 to 160 of about 487,455 (339)

Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration

Redox Biology, 2017
W. S. Hambright, R. S. Fonseca, Liuji Chen, Ren Na, Qitao Ran   +4 more
semanticscholar   +1 more source

Bimetallic Plasmonic Nanozyme‐Based Microneedle for Synergistic Ferroptosis Therapy of Melanoma

Advanced Science, EarlyView.
A microneedle (MN) patch that integrates novel bimetallic plasmonic nanozyme (BPNzyme) and traditional Chinese medicine β‐elemene (β‐ELE) has been rationally designed for ferroptosis pathway‐dependent combined therapy of melanoma. Abstract Melanoma is the most common malignant skin tumor, characterized by complexity, invasiveness, and heterogeneity ...
Wei Duan, Keying Xu, Yue Gao, Sheng Huang, Xueqian Xia, Xiang Liu, Shuangxue Pan, Chunpeng Jiao, Weijian Cheng, Yong Guo, Jingwen Zhao, Jia‐Wei Shen   +11 more
wiley   +1 more source

Targeting Neutrophil/Eosinophil Extracellular Traps by Aptamer‐Functionalized Nanosheets to Overcome Recalcitrant Inflammatory Disorders

Advanced Science, EarlyView.
In this study, C‐TAH, as multifunctional nanosheets, is developed with tannic acid and histone aptamer coverage. C‐TAH displays mild cytotoxicity, robust dsDNA and NETs/EETs binding efficiency, and potent antioxidant and antibacterial ability in vitro. C‐TAH treatment ameliorates dysregulated inflammation and restores hearing function in animal models,
Yongqiang Xiao, Xinyue Wang, Ming Liu, Xiao Fu, Nanfeng Zhang, Wenqing Yang, Junyi Ge, Yangyang Li, Duan Ma, Jing Ma, Weiping Wen, Dongdong Ren, Tianyu Zhang, Zhaoxu Tu   +13 more
wiley   +1 more source

Glutathione Peroxidase and Selenoprotein P Evaluation in Well-Being Assessment After Total Thyroidectomy. [PDF]

Int J Mol Sci
Traini E, Ianni F, Vergani E, Carnassale G, Daloiso G, Mancini A, Silvestrini A.   +6 more
europepmc   +1 more source

Glutathione peroxidase 4: a new player in neurodegeneration?

Molecular Psychiatry, 2017
Bárbara Rita Cardoso, Dominic J. Hare, Dominic J. Hare, Ashley I. Bush, Blaine R. Roberts   +4 more
semanticscholar   +1 more source

A Tailored Artificial Biocatalyst for Bacterial Endophthalmitis Therapy via Enhanced Ferroptosis‐Like Death

Advanced Science, EarlyView.
A tailored bio‐targeted catalytic strategy based on a bacteria‐specific artificial biocatalyst (MoS2/Fe@mercaptophenylboronic acid@hyaluronic acid, MFBH) is proposed for treating bacterial endophthalmitis. This strategy exhibits high‐efficiency peptidoglycan‐targeted bactericidal efficacy in vivo following a single intravitreal injection of an ...
Caixia Sun, Yingying Jiang, Shibo Zhang, Zhipeng Ding, Lijun Pu, Xinmei Liu, Jun Yang, Xiangkai Zhuge, Jianjun Dai, Yanmin Ju   +9 more
wiley   +1 more source

Assessment of the participation of sulfhydryl proteins in the glutathione peroxidase mimicry of diphenyl diselenide in the presence of thiol alkylating agent. [PDF]

Sci Rep
Ale EM, Kade IJ, Timothy MJ, Boyi RN, Asuelimen SO, Ayo VI, Toluwalase EK, Abah MA, Nnamani EO.   +8 more
europepmc   +1 more source

Cryo‐Inactivated Cancer Cells Derived Magnetic Micromotors for Tumor Immunotherapy

Advanced Science, EarlyView.
Cryo‐inactivated cancer cell‐based magnetic micromotors are developed for synergistic tumor immunotherapy via magnetic targeting. These micromotors can induce ferroptosis and immunogenic cell death, deliver tumor antigens, and activate the Mn2+‐dependent cGAS‐STING pathway. The system effectively suppresses tumor progression, recurrence, and metastasis,
Qingfei Zhang, Gaizhen Kuang, Wenzhao Li, Yuanjin Zhao   +3 more
wiley   +1 more source

Stress Management: How the Endoplasmic Reticulum Mitigates Protein Misfolding and Oxidative Stress by the Dual Role of Glutathione Peroxidase 8. [PDF]

Biomolecules
Yang Y, Peng H, Meng D, Fa Z, Yao C, Lin X, Schick J, Jin X.   +7 more
europepmc   +1 more source

Lysosome‐Featured Cell Aggregate‐Released Extracellular Vesicles Regulate Iron Homeostasis and Alleviate Post‐Irradiation Endothelial Ferroptosis for Mandibular Regeneration

Advanced Science, EarlyView.
Lysosomal redistribution occurs via extracellular vesicles in multi‐stem cell aggregates and controls iron homeostasis for safeguarding cell aggregation. These cell aggregate‐released extracellular vesicles (CA‐EVs) rescue lysosomal impairments and exert anti‐ferroptosis effects in recipient irradiated endothelial cells.
Yuan‐Yuan Li, Bo Ma, Jia‐Wei Lu, Kai‐Chao Zhang, Chao Ma, Sheng‐Feng Bai, Yan‐Jiao Li, Si‐Qi Ying, Wei‐Zong Weng, Kai Zhang, Xi‐Wang Hu, Rang Li, Chen‐Xi Zheng, Xiao‐Ru Xu, Ji Chen, Fang Jin, Hao‐Kun Xu, Jian‐Wei Xie, Yan Jin, Yi Shuai, Bing‐Dong Sui   +20 more
wiley   +1 more source