Results 161 to 170 of about 151,919 (337)

Pharmacological effects of gastrodin: Insight into neurological diseases and mechanism in ferroptosis and pyroptosis

open access: yesIbrain, Volume 11, Issue 1, Page 74-83, Spring 2025.
Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley   +1 more source

Developmental Changes in Hepatic Antioxidant Capacity Are Age- and Sex-Dependent

open access: yesJournal of Pharmacological Sciences, 2009
Developmental inadequacy in hepatic antioxidant defenses may contribute to chemical toxicity and pediatric liver diseases. We measured a comprehensive panel of antioxidants in liver tissue from 27 normal pediatric donors.
Shogo J. Miyagi   +3 more
doaj  

Non-covalent inhibitors of thioredoxin glutathione reductase with schistosomicidal activity in vivo. [PDF]

open access: yesNat Commun, 2023
Petukhova VZ   +20 more
europepmc   +1 more source

Glutathione derivatives as inhibitors of glutaredoxin and ribonucleotides reductase from Escherichia coli [PDF]

open access: bronze, 1982
Jan‐Olov Höög   +4 more
openalex   +1 more source

RRM2‐targeted nanocarrier enhances radiofrequency ablation efficacy in hepatocellular carcinoma through ferroptosis amplification and immune remodeling

open access: yesiMeta, EarlyView.
This study proposes an innovative therapeutic approach by combining RRM2 gene knockout with a nanocarrier system, significantly enhancing the efficacy of radiofrequency ablation for hepatocellular carcinoma. The study developed a tumor microenvironment‐responsive nanosystem that achieves synergistic effects through SPIO‐mediated and RRM2 knockout ...
Weiliang Hou   +19 more
wiley   +1 more source

Ascorbate-glutathione cycle in wheat and rice seedlings under anoxia and subsequent reaeration

open access: yesВавиловский журнал генетики и селекции
The most important part of the plant antioxidant system is the ascorbate-glutathione cycle (AGC), the activity of which is observed upon exposure to a range of stressors, including lack of O2, and oxidative stress occurring immediately after the ...
V. V. Yemelyanov   +4 more
doaj   +1 more source

Tailoring Targeted Therapy to Individual Patients: Lessons to be Learnt from the Development of Mitomycin C [PDF]

open access: yes, 2007
The modern era of targeted therapeutics offers the potential to tailor therapy to individual patients whose tumours express a specific target. Previous attempts to forecast tumour response to conventional chemotherapeutics based on similar principles ...
Phillips, Roger M, Volpato, Milene
core  

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