Results 221 to 230 of about 164,189 (356)

Coenzyme A mitigates cystine‐deprivation‐induced ferroptosis by suppressing the iron‐starvation response

The FEBS Journal, EarlyView.
Cystine (Cys2) deprivation in pancreatic cancer cells induces oxidative stress that destabilizes cytosolic iron–sulfur cluster (ISC) proteins, triggering an iron‐regulatory protein (IRP)‐mediated iron‐starvation response (ISR). This leads to increased iron uptake (via TFRC), an expanded labile iron pool, and ferroptosis.
Mingjun Tan, Yunzhan Li, Lei Sang, Min Wang, Qin Li, Zekun Li, Dongxiao Sun, Xiuchao Wang, Shengyu Yang   +8 more
wiley   +1 more source

Glutathione reductase underlies the stability of mutant p53 by antagonizing protein glutathionylation. [PDF]

Redox Biol
Wang L, Zhong S, Fan X, Xu Y, Wang M, Xu Y, Cai Y, Cao Z, Ye Z, Wen L, Wei P.   +10 more
europepmc   +1 more source

Probing the Surface of a Parasite Drug Target Thioredoxin Glutathione Reductase Using Small Molecule Fragments. [PDF]

ACS Infect Dis, 2021
Fata F, Silvestri I, Ardini M, Ippoliti R, Di Leandro L, Demitri N, Polentarutti M, Di Matteo A, Lyu H, Thatcher GRJ, Petukhov PA, Williams DL, Angelucci F.   +12 more
europepmc   +1 more source

The C‐terminal fragment of human glutathione reductase contains the postulated catalytic histidine [PDF]

, 1979
Renate Untucht‐Grau, Georg E. Schulz, R. Heiner Schirmer   +2 more
openalex   +1 more source

ER proteostasis meets mitochondrial function: contact sites as hubs of communication and therapeutic targets

The FEBS Journal, EarlyView.
Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna, Alessandro Cherubini, Ersilia Varone, Serena Germani, Alice Marrazza, Ester Zito   +5 more
wiley   +1 more source

Glutathione reductase plays a role in the metabolism of methylmercury degradation in <i>Rhodotorula mucilaginosa</i>. [PDF]

Microbiol Spectr
Guo Y, Deng W, Mo Q, Yu Y, Zhang Z, Wei M, Tang R, Lu S, Su Y.   +8 more
europepmc   +1 more source

Superoxide Dismutase and Glutathione Reductase as Indicators of Oxidative Stress Levels May Relate to Geriatric Hip Fractures' Survival and Walking Ability: A Propensity Score Matching Study. [PDF]

Clin Interv Aging, 2022
Liu M, Yang C, Chu Q, Fu X, Zhang Y, Sun G.   +5 more
europepmc   +1 more source

The mechanism of thioredoxin reductase from human placenta is similar to the mechanisms of lipoamide dehydrogenase and glutathione reductase and is distinct from the mechanism of thioredoxin reductase from Escherichia coli

, 1997
L. David Arscott, Stephan Gromer, R. Heiner Schirmer, Katja Becker, Charles H. Williams   +4 more
openalex   +2 more sources

The competitive interplay of 12‐oxophytodienoic acid (OPDA), protein thiols, and glutathione

The FEBS Journal, EarlyView.
12‐Oxophytodienoic acid (OPDA) is a phytohormone involved in plant growth and stress defense. Due to its cyclopentenone moiety, OPDA can form Michael adducts with thiol‐containing compounds such as glutathione and cysteine residues of proteins, resulting in alterations of the cellular redox regulatory network.
Madita Knieper, Ruben Schwarz, Lara Vogelsang, Jens Sproß, Armağan Kaya, Maike Bittmann, Harald Gröger, Andrea Viehhauser, Karl‐Josef Dietz   +8 more
wiley   +1 more source

Measuring the rate of NADPH consumption by glutathione reductase in the cytosol and mitochondria. [PDF]

PLoS One
Ting KKY, Floro E, Dow R, Jongstra-Bilen J, Cybulsky MI, Rocheleau JV.   +5 more
europepmc   +1 more source