Results 91 to 100 of about 166,309 (308)
Spatiotemporal Targeting Randle Cycle and Immune Checkpoint for Potent Antitumor Therapy
Advanced Science, EarlyView.A glucose oxidase‐based nanogel (GOX‐NG) system using catechol‐functionalized alginate, exhibits enhanced tumor penetration, prolonged retention, and sustained glucose depletion in the tumor microenvironment. When combined with a fatty acid oxidation inhibitor, it implements dual metabolic suppression, thereby enhancing ROS‐induced immunogenic cell ...
Yuan Gao +11 more
wiley +1 more source
Журнал инфектологии, 2017 In 178 patients with different clinical forms of pulmonary tuberculosis carried out pharmacogenetic testing to determine gene polymorphism glutathione S-transferase system (GSTM1, GSTT1).
N. A. Stepanova +2 more
doaj +1 more source
Expression of Glutathione S-transferase-pi (GST-pi)and Metallothionein (MT)in Lung Cancer [PDF]
, 1997 細胞内解毒酵素であるグルタチオンS一トランスフェラーゼπ(GST一π)やメタロチオネイン(MT)が癌細胞の抗癌剤耐性に関与していることが実験的に示唆されている.本研究では, GST一πとMTの発現を手術肺癌97例で免疫組織染色にて分析し, 化学療法との関係を検討した.GST一πは未治療の非小細胞肺癌56例て86%陽性と小細胞肺癌より有意に発現が高かった ...
岡, 三喜男 +9 more
core
Advanced Science, EarlyView.This non‑enzymatic function of DHODH drives sunitinib resistance by competing with TRIM37 to block TRIM28 ubiquitination, thereby stabilizing TRIM28 and activating VEGFA transcription. Disrupting the DHODH–TRIM28 interaction with lisaftoclax restores drug sensitivity.
Shijie Qian +10 more
wiley +1 more source
Journal of Pharmacological Sciences, 2010 We investigated the effects of treatment with trimethyltin (TMT) on the expression of glutathione-related enzymes in mouse hippocampus. TMT promoted the expression of glutathione S-transferase (GST) Ya/Yc mRNA, and GSTA2 protein, but not that of ...
Reiko Nagashima +4 more
doaj +1 more source
The Role of Glutathione Transferases in the Detoxification of TNT [PDF]
, 2010 Manufacture, use, storage and improper disposal of the explosive 2,4,6-trinitrotoluene (TNT) have led to widespread, global contamination of soil and groundwater.
Sparrow, Helen
core
Advanced Science, EarlyView.A bismuth–copper diselenide–based nanoplatform (BSCS@PHY) coordinates immunogenic cell death with local A2A receptor blockade in 4T1 tumors. Thermally triggered shell melting exposes catalytic surfaces for glutathione depletion and chemodynamic ROS generation, while co‐delivering an A2AR antagonist and yeast‐wall adjuvant to enhance dendritic‐cell ...
Xiangting Yi +12 more
wiley +1 more source
Glutathione metabolism in Urtica dioica in response to cadmium based oxidative stress
Biologia Plantarum, 2016 To investigate the antioxidative response of glutathione metabolism in Urtica dioica L. to a cadmium induced oxidative stress, activities of glutathione reductase (GR), glutathione-S-transferase (GST), and glutathione peroxidase (GSH-Px), content of ...
L. Tarhan, B. Kavakcioglu
doaj +1 more source
INTERACTIONS AMONG GLUTATHIONE S-TRANSFERASE, GLUTATHIONE REDUCTASE ACTIVITY AND GLUTATHIONE CONTENTS IN LEAVES OF Vicia faba L. SUBJECTED TO FLUROCHLORIDONE [PDF]
, 2012 In this study, Vicia sativa L. Selcuk-99 plant was treated with post-emergence flurochloridone in a concentration range of 11-72 mM. The effects of post-emergence flurochloridone treatments upon glutathione levels, glutathione s-transferase and ...
Yigit, Emel, Kaya, Armagan
core
Advanced Science, EarlyView.Chronic microinflammation in high myopia suppresses MANF in lens epithelial cells. MANF normally resides within MAMs and promotes ubiquitin‐mediated degradation of the ER Ca2+ pump SERCA2. MANF loss causes pathological SERCA2 accumulation, MAM hyperassembly, and disrupted ER‐to‐mitochondria Ca2+ transfer, leading to mitochondrial failure, oxidative ...
Xin Liu +8 more
wiley +1 more source