Results 1 to 10 of about 16,021,849 (210)

Reduction of MTT by Glutathione S-Transferase [PDF]

BioTechniques, 1998
The reduction of the tetrazolium salt 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) to a blue formazan product is widely used for assaying cell survival and proliferation.
J.L. York, L.C. Maddox, P. Zimniak, T.E. McHugh, D.F. Grant   +4 more
doaj   +3 more sources

Glutathione S-transferase M1 and T1 null polymorphisms and risk of oral submucous fibrosis: a meta-analysis of South Asian populations [PDF]

BMC Oral Health
Background Oral submucous fibrosis (OSMF) is a precancerous condition prevalent in individuals who habitually consume areca nut products. While environmental risk factors play a significant role in OSMF, genetic predisposition—particularly involving ...
Paria Motahari, Negin Neshanifard
doaj   +2 more sources

Glutathione S-Transferases in Cancer [PDF]

Antioxidants, 2021
In humans, the glutathione S-transferases (GST) protein family is composed of seven members that present remarkable structural similarity and some degree of overlapping functionalities. GST proteins are crucial antioxidant enzymes that regulate stress-induced signaling pathways.
Rahul Raj Singh, Katie M. Reindl
openaire   +3 more sources

Glutathione S-Transferases in Pediatric Cancer [PDF]

Frontiers in Oncology, 2011
The glutathione S-transferases (GSTs) are a family of ubiquitously expressed polymorphic enzymes important for detoxifying endogenous and exogenous compounds. In addition to their classic activity of detoxification by conjugation of compounds with glutathione, many other functions are now found to be associated with GSTs.
Luo, Wen, Kinsey, Michelle, Schiffman, Joshua D., Lessnick, Stephen L.   +3 more
openaire   +3 more sources

The expression of GST isoenzymes and p53 in non-small cell lung cancer.

Folia Histochemica et Cytobiologica, 2010
This study investigated the immunohistochemical staining characteristics of glutathione-S-transferase alpha, pi, mu, theta and p53 in non-small cell lung carcinoma and normal lung tissue from 50 patients.
MĂźzeyyen Ozhavzali, UlkĂź Yazici, Funda Demirag, Mehtap Aydin, Serpil OguztĂźzun, Murat Kiliç, Mesude Iş can   +6 more
doaj   +1 more source

Genetic polymorphisms of glutathione S-transferase Mu 1, glutathione S-transferase theta 1, and glutathione S-transferase P1 in oral squamous cell carcinoma: A case-control study in Iranian population

Journal of Orofacial Sciences, 2015
Background: Gene variability related to activation and detoxification of procarcinogens affects the susceptibility to oral squamous cell carcinoma (OSCC).
Bahram Yaghmaei, Kaveh Yaghmaei, Mohammad Jafarian, Shima Golmohammadi   +3 more
doaj   +1 more source

Glutathione S-transferase M1 and T1 polymorphisms and the risk of mild hepatotoxicity induced by carbamazepine in a tunisian population study

BMC Neurology, 2018
Background The aim of this study was to evaluate whether the glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) null alleles may contribute to carbamazepine-induced hepatotoxicity.
Chahra Chbili, Anis Hassine, Neila Fathallah, Manel Nouira, Salma Naija, Sofiene Ben Ammou, Saad Saguem   +6 more
doaj   +1 more source

The Role of Glutathione-S Transferase in Psoriasis and Associated Comorbidities and the Effect of Dimethyl Fumarate in This Pathway

Frontiers in Medicine, 2022
Psoriasis vulgaris is a chronic inflammatory skin disease characterized by well-demarcated scaly plaques. Oxidative stress plays a crucial role in the psoriasis pathogenesis and is associated with the disease severity.
Elena Campione, Sara Mazzilli, Monia Di Prete, Monia Di Prete, Annunziata Dattola, Terenzio Cosio, Daniele Lettieri Barbato, Daniele Lettieri Barbato, Gaetana Costanza, Caterina Lanna, Valeria Manfreda, Ruslana Gaeta Schumak, Francesca Prignano, Filadelfo Coniglione, Fabrizio Ciprani, Katia Aquilano, Luca Bianchi   +16 more
doaj   +1 more source

Does occupational exposure to solvents and pesticides in association with glutathione S-transferase A1, M1, P1, and T1 polymorphisms increase the risk of bladder cancer? The Belgrade case-control study.

PLoS ONE, 2014
ObjectiveWe investigated the role of the glutathione S-transferase A1, M1, P1 and T1 gene polymorphisms and potential effect modification by occupational exposure to different chemicals in Serbian bladder cancer male patients.Patients and methodsA ...
Marija G Matic, Vesna M Coric, Ana R Savic-Radojevic, Petar V Bulat, Marija S Pljesa-Ercegovac, Dejan P Dragicevic, Tatjana I Djukic, Tatjana P Simic, Tatjana D Pekmezovic   +8 more
doaj   +1 more source

Metabolism of hydroperoxy-phospholipids in human hepatoma HepG2 cells

Journal of Lipid Research, 1996
Two enzymatic mechanisms have been proposed for the metabolism of hydroperoxy-phospholipids: i) the combined action of phospholipase A2 and glutathione peroxidase, and/or ii) direct enzymatic reduction.
Y Bao, G Williamson
doaj   +1 more source