Results 141 to 150 of about 21,538,465 (192)

Glutathione S-Transferases

1977
Any symposium which deals with the metabolic formation and inactivation of reactive metabolites must necessarily consider the prominent role played by glutathione (GSH) and the glutathione transferases since this simple tripeptide (Fig. 1) and the enzymes which employ GSH as a cosubstrate represent a very important factor in the protection of cellular ...
Donald M. Jerina, John R. Bend
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Glutathione S-transferases of lung: purification and characterization of human lung glutathione S-transferases

Lung, 1984
Glutathione S-transferases play a major role in the protection of tissues from the toxic effects of exnobiotics and the products of lipid peroxidation. In the present studies we demonstrate that human lung has two forms of glutathione (GSH) S-transferase having isoelectric pH of 4.9 and 9.2.
C A, Partridge, D D, Dao, Y C, Awasthi
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Molecular Phylogeny of Glutathione-S-Transferases

DNA and Cell Biology, 1997
The glutathione-S-transferase (GST) protein superfamily is currently composed of nearly 100 sequences. This study documents a greater phylogenetic diversity of GSTs than previously realized. Parsimony and distance phylogenetic methods of GST amino acid sequences yielded virtually the same results. There appear to be at least 25 groups (families) of GST-
M J, Snyder, D R, Maddison
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Glutathione-S-transferase family of enzymes

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2001
The loci encoding the glutathione-S-transferase (GST) enzymes comprise a large supergene family located on at least seven chromosomes. The function of the GST enzymes has traditionally been considered to be the detoxication of electrophiles by glutathione conjugation. A wide variety of endogenous (e.g.
R C, Strange, M A, Spiteri, S, Ramachandran, A A, Fryer   +3 more
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Low glutathione S -transferase dogs

Archives of Toxicology, 2004
Liver and kidney glutathione S-transferase (GST) activities to 1,2-dichloro-4-nitrobenzene (DCNB) as a substrate (GST-D activities) were measured in 280 dogs from five different breeders, and significant individual differences in this activity were observed in both organs. Interestingly, 34 out of the 280 dogs (i.e. 12.1%) were those in which liver GST-
Toshiyuki, Watanabe, Tomomi, Sugiura, Sunao, Manabe, Wataru, Takasaki, Yoshihiko, Ohashi   +4 more
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Human genes for glutathione S-transferases

Human Genetics, 1984
The tissue distribution of different glutathione S-transferases (GST) is analysed by electrophoresis. The existence of GST"e" (erythrocyte), GST3, GST1, and GST2 is confirmed. GST"e" the fastest and most thermolabile of different GST analysed is observed only in erythrocyte cells.
V, Laisney, , Nguyen Van Cong, M S, Gross, J, Frezal   +3 more
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Glutathione S-transferase in hormonal carcinogenesis

Chemico-Biological Interactions, 1998
Treatment with testosterone propionate (TP) and diethylstilbestrol (DES) or TP and estradiol (E2) for 8-9 months causes development of leiomyosarcomas in the vas deferens or uterus of Golden Syrian hamsters at a frequency of 100%. In males, treatment with estrogens alone results in renal tumors, fatal within 6 months.
C E, Hudson, M M, Kelly, D A, Schwartz, D A, Schofield, J E, DeHaven, B A, Schulte, J S, Norris   +6 more
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Glutathione S-transferases in esophageal cancer

Carcinogenesis, 1993
Glutathione content and glutathione S-transferase enzyme activity as well as isoenzyme composition were studied in normal gastric cardia, normal squamous esophageal epithelium and corresponding malignant tumor of 10 patients with esophageal cancer. Mean values of glutathione (38 +/- 6 versus 36 +/- 12 nmol/mg protein) and glutathione S-transferase ...
W H, Peters, T, Wobbes, H M, Roelofs, J B, Jansen   +3 more
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Enzymology of Cytosolic Glutathione S- Transferases

1994
Publisher Summary The glutathione S-transferases (GSTs) catalyze a range of reactions of glutathione (GSH) with hydrophobic electrophiles. Their most established role is the glutathione conjugation of electrophiles, which would otherwise cause toxic reactions with macromolecules.
B, Ketterer, L G, Christodoulides
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Enzymology of Microsomal Glutathione S-Transferase

1994
Publisher Summary The study of the microsomal glutathione transferase regarding molecular properties, substrate specificity, kinetic behavior, and activation mechanisms has advanced considerably over the past few years. Polyhalogenated hydrocarbons that form toxic and carcinogenic glutathione conjugates need to be characterized with the purified ...
C, Andersson, E, Mosialou, R, Weinander, R, Morgenstern   +3 more
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