Results 221 to 230 of about 166,309 (308)

The presence of glutathione S-transferase in recombinant S100A9 alters its effect on human sperm function. [PDF]

J Biomed Res
Massa E, Prez G, Ghersevich S.
europepmc   +1 more source

Identification of drug repurposing candidates for the treatment of polycystic kidney disease

British Journal of Pharmacology, EarlyView.
Background and Purpose Autosomal dominant polycystic kidney disease (ADPKD) is a leading cause of end‐stage renal disease with limited treatment options. Drug repurposing offers a promising strategy to find effective treatments. Experimental Approach We identified birinapant, bardoxolone methyl and salicylic acid as repurposing candidates for ADPKD and
Alina Meyer, Paraskevi Sotiropoulou, Koussai Bouker, Dennis Svedberg, Rebekkah Hammar, Hester Bange, Per Larsson, André Mateus, Daniel R. Dietrich, Per Artursson   +9 more
wiley   +1 more source

The association between the Glutathione S-transferase polymorphisms and addiction to opioids and methamphetamine in the Iranian population. [PDF]

Front Psychiatry
Eskandarion MR, Jafaripour S, Heidari F, Talebi E, Taleghani MR, Maserat N, Forutan M, Ghorbani R, Gharehdaghi J, Shirkoohi R, Raoofian R.   +10 more
europepmc   +1 more source

O‐GlcNAcylation of KAT2A Enhances Bladder Cancer Proliferation by Inhibiting the KAT2A‐TRIM22 Interaction

Cancer Science, EarlyView.
Lysine acetyltransferase 2A (KAT2A) is a transcriptional coactivator and a member of the Histone Acetyltransferase (HAT) family. While altered KAT2A activity has been implicated in various cancers, its role in bladder cancer (BLCA) remains poorly understood.
Wenjie Yang, Zhaoheng Jin, Ziyi Li, Weifeng Xu, Yingjie Li, Yueqiang Peng, Jie Dong, Lin Ma, Zhigang Ji   +8 more
wiley   +1 more source

Five glutathione S-transferase isozymes played crucial role in the detoxification of aflatoxin B₁ in chicken liver. [PDF]

J Anim Sci Biotechnol
Deng J, Peng Z, Xia Z, Mo Y, Guo L, Wei J, Sun L, Liu M.   +7 more
europepmc   +1 more source

A Highly Powered Large Outcomes Randomised Controlled Trial Will Usually, but Not Always, Have Balanced Groups at Baseline

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Objective The importance of randomised trials for discerning an intervention's effect rests on randomisation's ability to create groups with (on average) equal hazards of future outcomes. The frequency with which this does not occur in well‐designed large trials with a high event rate was studied.
Hertzel C. Gerstein, Zayeeda Labiba, Sibylle Hess, Kamel Mohammedi, Yueci Zhou, Shun Fu Lee   +5 more
wiley   +1 more source

In Silico Identification of Novel Compounds as Anthelmintics Against <i>Haemonchus contortus</i> Through Inhibiting β-Tubulin Isotype 1 and Glutathione S-Transferase. [PDF]

Animals (Basel)
Jin Y, Sehgal SA, Hassan F, Liu G.
europepmc   +1 more source

Investigating transthyretin variants H88R and I107V in amyloid priming: From destabilization to complete dissociation

The FEBS Journal, EarlyView.
Investigated mutations in transthyretin (TTR) disrupt the F87‐centered hydrophobic core that stabilizes its tetrameric structure. The mild I107V mutation weakens inter‐chain packing, while H88R fully abolishes tetramer formation, yielding a monomeric, aggregation‐prone form. Structural, biophysical, and computational analyses reveal that both mutations
István L. Bódy, Zsolt Fazekas, Nóra Wágner, Anna J. Kiss‐Szemán, Veronika Harmat, Zoltán Pozsonyi, Dóra K. Menyhárd, András Perczel   +7 more
wiley   +1 more source

Comparative Proteomic Analysis of Self-Compatible <i>Turnera</i> Mutants Suggests <i>Glutathione S-Transferase 8</i> Is Involved in Overcoming S-Morph Female Self-Incompatibility Response. [PDF]

Plant Direct
Henning PM, Chafe PDJ, Hamam HJ, Shore JS.   +3 more
europepmc   +1 more source

Wee1 kinase differentially regulates maize CDKA2;1a and CDKB1;1

The FEBS Journal, EarlyView.
In eukaryotes, Wee1 kinase inhibits the kinase activity of CDK/Cyc complexes through phosphorylation of a conserved residue in the CDK moiety. Wee1 is also present in plants, but has been scarcely studied. We have studied maize Wee1 regulation of CDKA/CycD2;2a or CDKB/CycD2;2a complexes.
Mingyar N. López‐Hernández, Estefany D. Guerrero‐Molina, Ulises Martínez‐Ortega, Aurora Lara‐Núñez, Jorge M. Vázquez‐Ramos   +4 more
wiley   +1 more source