Results 41 to 50 of about 21,521,606 (315)
Toxicology and Applied Pharmacology, 2015 4-Hydroxy-2-trans-nonenal (4HNE), one of the major end products of lipid peroxidation (LPO), has been shown to induce apoptosis in a variety of cell lines.
S. Singhal +5 more
semanticscholar +1 more source
Genetic polymorphisms of glutathione S transferase and cervical intraepithelial neoplasia
Romanian Journal of Laboratory Medicine, 2016 Aim: The present study aim to analyze the relationship between GST M/T genotypes of glutathione S-transferases and cervical intraepithelial neoplasia.
Daniel Mureșan +6 more
doaj +1 more source
Mechanism for the several activities of the glutathione S-transferases.
Journal of Biological Chemistry, 1976 The catalyzed reactions of GSH with organic nitrate and thiocyanate esters and with a series of chloronitrobenzene substrates have been investigated and the results used to formulate a mechanism for glutathione S-transferase catalysis.
J. Keen, William H. Habig, W. Jakoby
semanticscholar +1 more source
Glutathione transferases in soybean glycine max (L.) Merr [PDF]
, 1999 Glutathione transferases, also known as Glutathione S-transferases (GSTs), are a diverse group of enzymes that catalyse the conjugation of the tri-peptide glutathione to a wide range of electrophilic substrates.
Andrews, Christopher John
core
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Glutathione transferases in maize (zea mays) [PDF]
, 1998 The glutathione transferases (GSTs) of maize have been the most studied GSTs in plants, however much is still not known about these enzymes. In the course of the current study six GST subunits (Zm GSTs I, II and III, which have been reported previously ...
Dixon, D.P., Dixon, David Peter
core
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Glutathione S transferase polymorphisms influence on iron overload in β-thalassemia patients
Thalassemia Reports, 2013 In patients with β-thalassemia iron overload that leads to damage to vital organs is observed. Glutathione S transferase (GST) enzymes have an antioxidant role in detoxification processes of toxic substances. This role is determined genetically.
Serena Sclafani +5 more
doaj +1 more source
Role of glutathione transferases in herbicide detoxification in weeds [PDF]
, 1996 Glutathione transferases (GSTs) catalyse the conjugation of the electrophilic herbicides atrazine, metolachlor, alachlor and fluorodifen with the tripeptide glutathione (GSH).
Hatton, Pamela J., Hatton, P.J.
core
Versatile vector tools for efficient protein screening across multiple expression systems
FEBS Open Bio, EarlyView.A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu +5 more
wiley +1 more source