Results 71 to 80 of about 21,521,606 (315)

Renal Clearable Luminogenic Reporter for Ultrasensitive Influenza Virus Imaging and Efficient Antiviral Therapies Monitoring in Living Mice

Advanced Science, EarlyView.
A viral luminogenic reporter with chemiluminescence/fluorescence dual‐response and efficient renal clearance was developed for non‐invasive imaging and urinalysis of H1N1 virus protease, allowing for remote detection of H1N1 virus infections and monitoring of antiviral therapeutic efficacy in living mice.
Bankang Ruan, Chudan Liang, Meilin Hu, Weiping Xu, Jingjing Che, Jun Qian, Bingcai Jiang, Linna Liu, Xiancai Ma, Jiaguo Huang   +9 more
wiley   +1 more source

Human Dental Pulp Stem Cell Secretome Restores Ischemic Stroke–Impaired Motor and Cognitive Functions by Reprogramming Redox and Inflammatory Signaling

Advanced Science, EarlyView.
Human dental pulp stem cell secretome emerges as a cell‐free therapeutic strategy for ischemic stroke by reprogramming redox and inflammatory signaling. hDPSC secretome‐derived antioxidant and immunomodulatory factors suppress the TLR4–NOX–ROS–NF‐κB axis, reduce microglial inflammatory responses and apoptosis, and promote neurogenesis, angiogenesis ...
Kyung‐Joo Seong, Sehoon Park, Sun‐Woong Bae, Daseul Kim, Jin Ho Lee, Won‐Seok Choi, Zee‐Yong Park, Ji‐Yeon Jung, Won‐Jae Kim   +8 more
wiley   +1 more source

Glutathione-S-Crotonyl-N-Acetylthioethanolamine Alkenetransferase: Properties and Comparison with Other Glutathione-S-Transferases

, 1972
A mercapturic acid is an N-acetylated-S-substituted -L-cysteine in which the substitutive group is generally inert to further enzymic reaction (Wood, 1970).
Speir, Thomas Wilson, Speir, Thomas Wilson (11650369)   +1 more
core   +1 more source

The Plant‐to‐Plant Circular Strategy: Coupling Photodegradation and Phytoremediation With Plant‐Based Nanomaterials for Plastic Degradation

Advanced Science, EarlyView.
Plant‐based nanomaterials derived from alfalfa serve as dual‐function catalysts, coupling photodegradation and phytoremediation to degrade polyethylene under UV‐A light and in soil. The nanomaterials work synergistically with alfalfa and soil microbes, achieving efficient plastic breakdown without trophic transfer.
Haoran Liu, Lena Ciric, Yuheng Wang, Ziru Pei, Manpreet Bhatti   +4 more
wiley   +1 more source

Factors Influencing Glutathione S-transferases in Daphnia magna [PDF]

, 2006
Glutathione S-transferases (GSTs) are an important family of xenobiotic biotransforming enzymes that can make toxicity tests variable. Daphnia magna is commonly used in ecotoxicology testing because they are easy to culture, have a short life cycle, and ...
Smith, Lisa Stievater
core   +1 more source

Ahcy Acts as an Effector of Hnf4a‐Driven Super‐Enhancer Activation to Alleviate MASLD During Intermittent Fasting

Advanced Science, EarlyView.
Our study identifies an Hnf4a‐driven super‐enhancer of hepatic Ahcy that mediates the protective effects of intermittent fasting against MASLD. Disruption of the Ahcy super‐enhancer reduces Ahcy expression and exacerbates lipid accumulation. This pathway prevents aberrant promoter hypermethylation by maintaining the SAM/SAH balance, as exemplified by ...
Huafeng Chen, Shilin Zhang, Xiaojie Deng, Wenqiang Xie, Fen Xu, Jie Shen, Hua Liang   +6 more
wiley   +1 more source

Evolutionary conservation of regulated longevity assurance mechanisms [PDF]

, 2007
Background: To what extent are the determinants of aging in animal species universal? Insulin/ insulin-like growth factor ( IGF)-1 signaling ( IIS) is an evolutionarily conserved ( public) regulator of longevity; yet it remains unclear whether the genes ...
Linda Partridge, Piper, Matthew D., David Gems, Schuster, E, Piper, MD, Gems, D, McElwee, J.J., Thomas, J.H., Partridge, L., Joshua J McElwee, Withers, D.J., McElwee, JJ, Patel, DS, Dhaval S Patel, Thornton, J.M., Blanc, E, Matthew D Piper, McElwee, J.J, Patel, Dhaval S., Withers, Dominic J., Schuster, E., Dominic J Withers, Janet M Thornton, Selman, C, Withers, DJ, Thorton, Janet M., Selman, C., Eugene Schuster, Selman, Colin, Partridge, Linda, Piper, M.D., Blanc, Eric, Thomas, JH, Eric Blanc, Patel, D, McElwee, Joshua J., Gems, D., James H Thomas, Partridge, L, Blanc, E., Thornton, JM, Gems, David, Schuster, Eugene, Thomas, J H, Colin Selman, Piper, M D, Patel, D.S., Thomas, James H.   +47 more
core   +1 more source

Rocket‐Inspired Sequentially Targeted Nanotherapeutics for Mitochondrial Regulation and Inflammatory Reprogramming in Ischemic Stroke

Advanced Science, EarlyView.
A novel neutrophil‐hitchhiking, rocket‐inspired nanoplatform is developed to cross the blood‐brain barrier for sequential, spatiotemporal drug delivery. By responsive surface transformation in the ischemic penumbra, it precisely targets mitochondria to suppress Drp1‐mediated fission.
He Bai, Zihao Yong, Yang Li, Qingmin Chen, Yong Liu, Xiaomeng Guo, Fukai Li, Shicheng Tang, Zhuo Yang, Yufei Zhang, Ruwei Jie, Xiaohong Lv, Huacheng Wang, Chunming Huang, Liwei Xie, Jianqi Xiao, Qingchun Mu, Longguang Tang   +17 more
wiley   +1 more source

The isozyme pattern of glutathione S-transferases in rat heart [PDF]

, 1984
The isozyme pattern of glutathione S-transferases of rat heart differs markedly from that of liver. Heart lacks the majority of basic isozymes recognized in rat liver, and isoelectric focusing of glutathione S-transferases obtained from affinity ...
Sies, Helmut, Toshihisa Ishikawa, Ishikawa, Toshihisa, Helmut Sies   +3 more
core   +1 more source

UFL1‐Mediated UFMylation of ENO1 Restrains Aerobic Glycolysis and Colorectal Cancer Progression

Advanced Science, EarlyView.
UFMylation restrains aerobic glycolysis and colorectal cancer progression by modifying the glycolytic enzyme ENO1. Pharmacological enhancement of the UFL1–ENO1 interaction by the FDA‐approved antibiotic torezolid promotes ENO1 UFMylation, suppresses tumor metabolism, and sensitizes colorectal cancer to chemotherapy, revealing an actionable metabolic ...
Xiuqing Ma, Rui Wan, Yueyuan Zhong, Ziyang Cui, Xuan Zhang, Xiaoqiang He, Rong Wang, Lei Huang, Wan‐Yang Sun, Rong‐Rong He, Yang Zhou, Jianshuang Li, Li Shen, Shao‐Hua Wang, Tongzheng Liu   +14 more
wiley   +1 more source