Results 111 to 120 of about 162,087 (219)

Stimulation of OGG1 Enhances Oxidative DNA Damage Repair and Protects Against Acute Liver Failure by Acetaminophen

Advanced Science, EarlyView.
Chemical switching of OGG1 by CMM‐98 accelerates oxidative DNA damage repair and enhances hepatocyte resilience during acetaminophen‐induced acute liver injury. By promoting efficient processing of OGG1‐generated repair intermediates, CMM‐98 reduces oxidative damage, preserves cellular integrity, and protects against acute liver failure, identifying ...
Zhenjun Zhao, Rahul Upadhyay, Alice Eddershaw, Chenchen Wang, Yudong Zhao, Olov Wallner, Jinhye Ryu, Nayere Taebnia, Heather Gildie, Emma Scaletti‐Hutchinson, Jonathan R. Davies, Nicole Ziegler, Andreas Krämer, Samantha C. Robinson, Marek Varga, Karolina Singerova, Zuzanna Szaruga, Elisée Wiita, İrşil Güneş, Sheila S. David, Stefan Knapp, Aimo Kannt, Miguel de Vega, Pål Stenmark, Volker M Lauschke, Maurice Michel   +25 more
wiley   +1 more source

Omega-Class Glutathione Transferases Protect DNA from Oxidative Stress in Pathogenic Helminth Reproductive Cells. [PDF]

Antioxidants (Basel), 2023
Kim JG, Kang I, Ahn CS, Sohn WM, Kong Y.
europepmc   +1 more source

Glutathione Transferases Preface

The Glutathione transferases (GSTs) are a super family of enzymes that are principally known for their role in the phase II detoxification reactions where they conjugate glutathione to a wide range of electrophilic compound sof exogenous and endogenous ...
Board, Philip
core   +1 more source

PLOD1 Catalytic Activity Stabilizes ENO1 by Limiting FBXW7‐dependent Degradation to Promote Glycolysis and TMZ Resistance in Glioblastoma

Advanced Science, EarlyView.
PLOD1 interacts with ENO1 and limits its FBXW7‐dependent ubiquitination and proteasomal degradation through a mechanism requiring PLOD1 catalytic activity. ENO1 stabilization sustains glycolysis, promoting glioblastoma cell proliferation, migration, and temozolomide resistance.
Fen Xue, Dingkong Liang, Xin Chen, Fei Fan, Xiayun He   +4 more
wiley   +1 more source

OXidative Stress PREDictor: A Supervised Learning Approach for Annotating Cellular Oxidative Stress States in Inflammatory Cells

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
OxSpred, an eXtreme‐Gradient‐Boosting‐‐based supervised learning model, accurately annotates oxidative stress in innate immune cells at the single‐cell level, providing interpretable embeddings with significant biological relevance. This innovative tool revolutionizes the understanding of innate immune cell functions during inflammation and enhances ...
Po‐Yuan Chen, Tai‐Ming Ko
wiley   +1 more source

Immune Modulatory Therapy for Severe Dengue Hemorrhagic Fever in a Patient With Mitochondrial Complex I Deficiency: A Case Report

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Dengue virus (DENV) poses a serious global health challenge, particularly in cases of dengue hemorrhagic fever (DHF). Patients with preexisting mitochondrial disorders may be at increased risk for complications due to the specific impact of DENV on mitochondrial‐dependent cellular processes and immune function.
Audra N. Iness, Ameya S. Walimbe, Emily R. Strouphauer, Michio Hirano, Alejandro D. Iglesias, Valentina Emmanuele, Caitlin C. Griffin, Sheldon L. Kaplan, William A. Gomes, Karen K. Moeller, Stephen F. Kralik, Fernando Scaglia   +11 more
wiley   +1 more source

Alterations of Renal Function Tests of Filling Station Workers with Respect of Genetic Polymorphisms of GSTM1 and GSTT1

پزشکی بالینی ابن سینا, 2004
The possible health effects of chronic exposure to petroleum products, in particular exposure to gasoline is an issue of public health concern. Filling station workers are at great risk of exposure to gasoline.
Maryam Ansari-Lari, Mostafa Saadat, Negin Hadi   +2 more
doaj  

Directed Evolution of Phi Class Glutathione Transferases Involved in Multiple-Herbicide Resistance of Grass Weeds and Crops. [PDF]

Int J Mol Sci, 2022
Ioannou E, Papageorgiou AC, Labrou NE.
europepmc   +1 more source

Diversidad e implicaciones de los polimorfismos de las enzimas glutatión S transferasas en la patogénesis del asma:-- Diversity and implications of glutathione S-transferase enzymes polymorphisms in the pathogenesis of asthma

MedUNAB, 2011
Las glutatión S-transferasas (GST) representan una superfamilia de enzimas presentes en todos los organismos aerobios. Existen tres familias principales que se encuentran ampliamente distribuidas en la naturaleza y se clasifican en citosólicas ...
Yosed Anaya Chávez, Biol, Beatriz Martínez, MSc   +1 more
doaj  

Role of human glutathione transferases in biotransformation of the nitric oxide prodrug JS-K. [PDF]

Sci Rep, 2021
Sjödin B, Mannervik B.
europepmc   +1 more source