Results 141 to 150 of about 162,087 (219)

Is there a role for tau glutathione transferases in tetrapyrrole metabolism and retrograde signalling in plants? [PDF]

Philos Trans R Soc Lond B Biol Sci, 2020
Sylvestre-Gonon E, Schwartz M, Girardet JM, Hecker A, Rouhier N.   +4 more
europepmc   +1 more source

Purification, Fluorescent Labeling, and Detyrosination of Mammalian Cell Tubulin for Biochemical Assays

Cytoskeleton, EarlyView.
ABSTRACT Microtubules play essential roles in numerous cellular processes. All microtubules are built from the protein tubulin, yet individual microtubules can differ spatially and temporally due to their tubulin isotype composition and post‐translational modifications (PTMs).
Ezekiel C. Thomas, Yang Yue, Morgan L. Pimm, Takashi Hotta, Ryoma Ohi, Kristen J. Verhey   +5 more
wiley   +1 more source

Detoxification of deoxynivalenol by pathogen-inducible tau-class glutathione transferases from wheat. [PDF]

J Biol Chem
Michlmayr H, Siller M, Kenjeric L, Doppler M, Malachova A, Hofer M, Hametner C, Schweiger W, Steiner B, Kugler KG, Mayer KFX, Buerstmayr H, Schuhmacher R, Krska R, Labrou NE, Papageorgiou AC, Adam G.   +16 more
europepmc   +1 more source

Cochlear detoxification: Role of alpha class glutathione transferases in protection against oxidative lipid damage, ototoxicity, and cochlear aging. [PDF]

Hear Res, 2021
Someya S, Kim MJ.
europepmc   +1 more source

Characterization of Lysosomal Hydrolases and Transporters and Their Age‐Dependent Variability: Relevance to Drug Metabolism and Transport of Small Molecule and Biologic Drugs

Clinical Pharmacology &Therapeutics, EarlyView.
Lysosomes play a key role in the accumulation, catabolism, and transport of endogenous and exogenous metabolites and proteins and are involved in drug metabolism and prodrug activation. However, the protein abundance and interindividual variability of lysosomal drug‐metabolizing enzymes and transporters (DMETs) remain underexplored.
Darshak Gadara, Dilip Kumar Singh, Sandhya Subash, Guihua Yue, Deepak Ahire, Chris Bohl, Maciej Czerwinski, Stephanie Helmstetter, Scott Heyward, Robert S. Jones, Cyrus Khojasteh, Ryota Kikuchi, Priyanka Kulkarni, Bin Ma, Bernard Murray, Chris Seib, Bill Smith, David M. Stresser, Mitchell E. Taub, Ting Wang, Bhagwat Prasad   +20 more
wiley   +1 more source

Human glutathione transferases catalyze the reaction between glutathione and nitrooleic acid. [PDF]

J Biol Chem
Steglich M, Larrieux N, Zeida A, Dalla Rizza J, Salvatore SR, Bonilla M, Möller MN, Buschiazzo A, Alvarez B, Schopfer FJ, Turell L.   +10 more
europepmc   +1 more source

Quantitative Systems Toxicology Model Predicts Obeticholic Acid‐Associated Liver Injury in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Clinical Pharmacology &Therapeutics, EarlyView.
Obeticholic acid (OCA), a synthetic analog of chenodeoxycholic acid, was approved in 2016 for the treatment of primary biliary cholangitis. Early clinical trials revealed elevated liver biomarkers in healthy subjects receiving supratherapeutic OCA doses (100–250 mg).
Abigail K. Mayo, James J. Beaudoin, Jeffrey L. Woodhead, Paul B. Watkins, Kim L. R. Brouwer   +4 more
wiley   +1 more source

Overlooked and misunderstood: can glutathione conjugates be clues to understanding plant glutathione transferases? [PDF]

Philos Trans R Soc Lond B Biol Sci
Micic N, Holmelund Rønager A, Sørensen M, Bjarnholt N.   +3 more
europepmc   +1 more source

Comparative analyses and structural insights of new class glutathione transferases in Cryptosporidium species. [PDF]

Sci Rep, 2020
Mfeka MS, Martínez-Oyanedel J, Chen W, Achilonu I, Syed K, Khoza T.   +5 more
europepmc   +1 more source

Functional profiling of STXBP1 missense variants using a novel dual‐readout fluorometric assay

Epilepsia, EarlyView.
Abstract Objective STXBP1‐related disorders (STXBP1‐RD) are among the most common genetic neurodevelopmental disorders, marked by early onset epilepsy, global developmental delay, and motor impairments. Many missense variants remain uncharacterized, limiting accurate variant interpretation and hindering development of precision therapies.
Elisa A. Waxman, Jennine M. Dawicki‐McKenna, Ian McSalley, Anna J. Prentice, Torrey A. Chisari, Sarah M. Ruggiero, Jillian L. McKee, Alex J. Felix, Giulia Pavani, Benjamin L. Prosser, Michael J. Boland, Ingo Helbig   +11 more
wiley   +1 more source