Results 231 to 240 of about 145,105 (353)

In Situ Gels for Nasal Delivery: Formulation, Characterization and Applications

Macromolecular Materials and Engineering, EarlyView.
Drug delivery through the nasal route offers many advantages, but is hampered by a number of challenges, such as the short drug retention time caused by mucociliary clearance. In situ forming gels, which undergo a sol‐to‐gel transition with specific triggers at the site of action, present real opportunities in this field.
Li Qian, Michael T. Cook, Cécile A. Dreiss   +2 more
wiley   +1 more source

Structure elucidation of glycoprotein glycans and of polysaccharides by NMR spectroscopy [PDF]

, 2000
Bas R. Leeflang, Elisabeth J. Faber, P. Erbel, Johannes F.G. Vliegenthart   +3 more
openalex   +1 more source

On‐Resin Recycling of Acid‐Labile Linker Enables the Reuse of Solid Support for Fmoc‐Based Solid Phase Synthesis

Macromolecular Rapid Communications, EarlyView.
This study introduces the first recyclable and reusable resin for Fmoc‐based solid phase synthesis (SPS) of oligamide‐based structures through the regeneration of a cyclic acetal‐based linker on Tentagel resins. Even after multiple recycling and reuse cycles of the solid phase, consistently high yields and high‐purity products are obtained. Abstract In
Nicholas Jäck, Laura Hartmann
wiley   +1 more source

Fast NMR-Based Assessment of Cancer-Associated Protein Glycosylations from Serum Samples. [PDF]

Anal Chem
Rudolph L, Krellmann R, Castven D, Jegodzinski L, Deriš H, Štambuk J, Mölbitz J, Dechent L, Sperling K, Lindloge M, Friedrich N, Schmelter F, Föh B, Trbojević-Akmačić I, Sina C, Nauck M, Petersmann A, Marquardt JU, Günther UL, Mallagaray A.   +19 more
europepmc   +1 more source

Protein glycosylation in lung cancer from a mass spectrometry perspective

Mass Spectrometry Reviews, EarlyView.
Abstract Lung cancer is a severe disease for which better diagnostic and therapeutic approaches are urgently needed. Increasing evidence implies that aberrant protein glycosylation plays a crucial role in the pathogenesis and progression of lung cancer.
Mirjam Balbisi, Simon Sugár, Lilla Turiák   +2 more
wiley   +1 more source

Mutation of Arg273 to Leu Alters the Specificity of the Yeast N-Glycan Processing Class I α1,2-Mannosidase [PDF]

, 2000
Pedro Romero, François Vallée, P. Lynne Howell, Annetté Herscovics   +3 more
openalex   +1 more source

Glycomics and Glycoproteomics Reveal Distinct Oligomannose Carriers Across Bladder Cancer Stages. [PDF]

Int J Mol Sci
Relvas-Santos M, Ferreira D, Brandão A, Afonso LP, Santos LL, Silva AMN, Ferreira JA.   +6 more
europepmc   +1 more source

Mapping protein–protein interactions by mass spectrometry

Mass Spectrometry Reviews, EarlyView.
Abstract Protein–protein interactions (PPIs) are essential for numerous biological activities, including signal transduction, transcription control, and metabolism. They play a pivotal role in the organization and function of the proteome, and their perturbation is associated with various diseases, such as cancer, neurodegeneration, and infectious ...
Xiaonan Liu, Lawrence Abad, Lopamudra Chatterjee, Ileana M. Cristea, Markku Varjosalo   +4 more
wiley   +1 more source

The ST3Gal-I Sialyltransferase Controls CD8+ T Lymphocyte Homeostasis by Modulating O-Glycan Biosynthesis [PDF]

, 2000
John J. Priatel, Daniel Chui, Nobuyoshi Hiraoka, Collan J.T Simmons, Kevin B Richardson, Dawne M. Page, Minoru Fukuda, Nissi Varki, Jamey D. Marth   +8 more
openalex   +1 more source

Mass spectrometry imaging of N‐linked glycans: Fundamentals and recent advances

Mass Spectrometry Reviews, EarlyView.
Abstract With implications in several medical conditions, N‐linked glycosylation is one of the most important posttranslation modifications present in all living organisms. Due to their nontemplate synthesis, glycan structures are extraordinarily complex and require multiple analytical techniques for complete structural elucidation.
Tana V. Palomino, David C. Muddiman
wiley   +1 more source