Results 1 to 10 of about 8,797 (182)
Correcting for sparsity and interdependence in glycomics by accounting for glycan biosynthesis
Nature Communications, 2021 Glycomics can uncover important molecular changes but measured glycans are highly interconnected and incompatible with common statistical methods, introducing pitfalls during analysis. Here, the authors develop an approach to identify glycan dependencies
Austin W T Chiang +2 more
exaly +2 more sources
Towards a standardized bioinformatics infrastructure for N- and O-glycomics
Nature Communications, 2019 Glycomics is gaining momentum in basic, translational and clinical research. Here, the authors review current reporting standards and analysis tools for mass-spectrometry-based glycomics, and propose an e-infrastructure for standardized reporting and ...
Vignesh Venkatakrishnan +2 more
exaly +2 more sources
Metabolites, 2020 Glycomics measurements, like all other high-throughput technologies, are subject to technical variation due to fluctuations in the experimental conditions. The removal of this non-biological signal from the data is referred to as normalization.
Igor Rudan +2 more
exaly +3 more sources
Compositional data analysis enables statistical rigor in comparative glycomics
Nature CommunicationsComparative glycomics data are compositional data, where measured glycans are parts of a whole, indicated by relative abundances. Applying traditional statistical analyses to these data often results in misleading conclusions, such as spurious “decreases”
Morten Andersen +2 more
exaly +2 more sources
Nature Communications, 2023 Mucosally active subunit vaccines are an unmet clinical need due to lack of licensed immunostimulants suitable for vaccine antigens. Here, we show that intranasal administration of liposomes incorporating: the Streptococcus pyogenes peptide antigen, J8 ...
Victoria Ozberk +13 more
doaj +1 more source
Preclinical safety and immunogenicity of Streptococcus pyogenes (Strep A) peptide vaccines
Scientific Reports, 2021 We have developed two candidate vaccines to protect against multiple strains of Strep A infections. The candidates are combinatorial synthetic peptide vaccines composed of a M protein epitope (J8 or p*17) and a non-M protein epitope (K4S2).
Simone Reynolds +7 more
doaj +1 more source
Discovery of Cofactor Competitive Inhibitors against the Human Methyltransferase Fibrillarin
Pharmaceuticals, 2021 Fibrillarin (FBL) is an essential and evolutionarily highly conserved S-adenosyl methionine (SAM) dependent methyltransferase. It is the catalytic component of a multiprotein complex that facilitates 2′-O-methylation of ribosomal RNAs (rRNAs), a ...
Yun Shi +6 more
doaj +1 more source
Microbiology Spectrum, 2023 Escherichia coli signal peptidase I (LepB) has been shown to inefficiently cleave secreted proteins with aromatic amino acids at the second position after the signal peptidase cleavage site (P2′).
Joanna E. Musik +8 more
doaj +1 more source
mBio, 2023 Malaria is a leading cause of illness and death in children under 5 years of age in Sub-Saharan Africa. Currently, there is no highly efficacious malaria vaccine capable of inducing long-lasting immunity.
Winter A. Okoth +11 more
doaj +1 more source
Introduction to a special issue, “Expanded glycomics: A bridge over future glycomics” [PDF]
BBA AdvancesJun Hirabayashi, Yann Guerardel
doaj +2 more sources