Results 1 to 10 of about 8,738 (176)
Compositional data analysis enables statistical rigor in comparative glycomics [PDF]
Nature CommunicationsComparative glycomics data are compositional data, where measured glycans are parts of a whole, indicated by relative abundances. Applying traditional statistical analyses to these data often results in misleading conclusions, such as spurious “decreases”
Alex Bennett +2 more
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Shotgun glycomics: a microarray strategy for functional glycomics [PDF]
Nature Methods, 2010 Major challenges of glycomics are to characterize a glycome and identify functional glycans as ligands for glycan-binding proteins (GBPs). To address these issues we developed a general strategy termed shotgun glycomics. We focus on glycosphingolipids (GSLs), a class of glycoconjugates that is challenging to study, recognized by toxins, antibodies and ...
Xuezheng Song +2 more
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Correcting for sparsity and interdependence in glycomics by accounting for glycan biosynthesis
Nature Communications, 2021 Glycomics can uncover important molecular changes but measured glycans are highly interconnected and incompatible with common statistical methods, introducing pitfalls during analysis. Here, the authors develop an approach to identify glycan dependencies
Bokan Bao +2 more
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Towards a standardized bioinformatics infrastructure for N- and O-glycomics
Nature Communications, 2019 Glycomics is gaining momentum in basic, translational and clinical research. Here, the authors review current reporting standards and analysis tools for mass-spectrometry-based glycomics, and propose an e-infrastructure for standardized reporting and ...
Julien Mariéthoz +2 more
exaly +2 more sources
Metabolites, 2020 Glycomics measurements, like all other high-throughput technologies, are subject to technical variation due to fluctuations in the experimental conditions. The removal of this non-biological signal from the data is referred to as normalization.
Nathalie Gerstner +2 more
exaly +3 more sources
Marine medicinal glycomics [PDF]
Frontiers in Cellular and Infection Microbiology, 2014 Glycomics is an international initiative aimed to understand the structure and function of the glycans from a given type of cell, tissue, organism, kingdom or even environment, as found under certain conditions.
Vitor Hugo Pomin
doaj +3 more sources
Advances in total glycomic analysis including sialylated sub-glycan isomers by SALSA method [PDF]
BBA AdvancesAll eukaryotic cell surfaces are coated with various types of glycans, which are essential molecules in biological events. In this review, we summarize recent integrated glycomics studies using various biological samples.
Masaki Kurogochi +3 more
doaj +2 more sources
Toward spatial glycomics and glycoproteomics: Innovations and applications [PDF]
BBA AdvancesIn this mini review, we provide an overview of the challenging field of spatial glycomics/glycoproteomics. Owing to their complexity, sophisticated analytical methods and innovative technologies are needed to advance this field.
Patcharaporn Boottanun +2 more
doaj +2 more sources
Proceedings of the National Academy of Sciences, 2009 Molecular imaging enables visualization of specific molecules in vivo and without substantial perturbation to the target molecule's environment. Glycans are appealing targets for molecular imaging but are inaccessible with conventional approaches.
Scott T, Laughlin, Carolyn R, Bertozzi
openaire +2 more sources
Nature Communications, 2023 Mucosally active subunit vaccines are an unmet clinical need due to lack of licensed immunostimulants suitable for vaccine antigens. Here, we show that intranasal administration of liposomes incorporating: the Streptococcus pyogenes peptide antigen, J8 ...
Victoria Ozberk +13 more
doaj +1 more source