Results 41 to 50 of about 15,452 (231)

Pneumococcal Phasevarions Control Multiple Virulence Traits, Including Vaccine Candidate Expression

Microbiology Spectrum, 2022
Streptococcus pneumoniae is the most common cause of bacterial illness worldwide. Current vaccines based on the polysaccharide capsule are only effective against a limited number of the >100 capsular serotypes.
Zachary N. Phillips, Claudia Trappetti, Annelies Van Den Bergh, Gael Martin, Ainslie Calcutt, Victoria Ozberk, Patrice Guillon, Manisha Pandey, Mark von Itzstein, W. Edward Swords, James C. Paton, Michael P. Jennings, John M. Atack   +12 more
doaj   +1 more source

A structural and functional model for human bone sialoprotein [PDF]

, 2012
Human bone sialoprotein (BSP) is an essential component of the extracellular matrix of bone. It is thought to be the primary nucleator of hydroxyapatite crystallization, and is known to bind to hydroxyapatite, collagen, and cells.
Durrant, Marcus, Vincent, Kevin
core   +1 more source

N-Glycomics of Human Erythrocytes [PDF]

International Journal of Molecular Sciences, 2021
Glycosylation is a complex post-translational modification that conveys functional diversity to glycoconjugates. Cell surface glycosylation mediates several biological activities such as induction of intracellular signaling pathway and pathogen recognition.
Rosaria Ornella Bua, Angela Messina, Luisa Sturiale, Rita Barone, Domenico Garozzo, Angelo Palmigiano   +5 more
openaire   +5 more sources

Profiling of Glycan Receptors for Minute Virus of Mice in Permissive Cell Lines Towards Understanding the Mechanism of Cell Recognition [PDF]

, 2013
The recognition of sialic acids by two strains of minute virus of mice (MVM), MVMp (prototype) and MVMi (immunosuppressive), is an essential requirement for successful infection.
Agbandje-McKenna, M, Chen, X, Cotmore, S, Cummings, RD, Dell, A, Halder, S, Haslam, SM, Heimburg-Molinaro, J, McKenna, R, North, SJ, Smith, DF, Tattersall, P, Trollope, AJ   +12 more
core   +1 more source

Multiplexed Tandem Mass Spectrometry Imaging Enables Large‐Scale Isomer Mapping and Annotation in Tissues

Angewandte Chemie, EarlyView.
Parallel mass spectrometry imaging acquires high mass resolution and tandem mass spectrometry images from 108 isolation windows in a single run. Spatial similarity networking clusters product ions by spatial distribution, enabling annotation of isomers and isobars as demonstrated for phospholipids and oxidized cholesterol in mouse and human brain ...
Varun V. Sharma, Gabor Toth, Robert Martinis, Cathrin E. Hansen, Gijs Kooij, Ingela Lanekoff   +5 more
wiley   +2 more sources

The impact of the butterfly effect on human parainfluenza virus haemagglutinin-neuraminidase inhibitor design

Scientific Reports, 2017
Human parainfluenza viruses represent a leading cause of lower respiratory tract disease in children, with currently no available approved drug or vaccine.
Larissa Dirr, Ibrahim M. El-Deeb, Leonard M. G. Chavas, Patrice Guillon, Mark von Itzstein   +4 more
doaj   +1 more source

The impact of elevation of total bilirubin level and etiology of the liver disease on serum N-glycosylation patterns in mice and men [PDF]

, 2010
The GlycoFibroTest and GlycoCirrhoTest are noninvasive alternatives for liver biopsy that can be used as a follow-up tool for fibrosis patients and to diagnose cirrhotic patients, respectively.
BLOMME, BRAM, Callewaert, Nico, Colle, Isabelle, Van Steenkiste, Christophe, Van Vlierberghe, Hans, Vanhuysse, Jacques   +5 more
core   +1 more source

Bioinformatics Approach for Functional Glycomics [PDF]

, 2007
Presentation in the Human Glycomics Proteomics Disease Initiative (HGPI ...
James C. Paulson
core   +2 more sources

Glycomics

, 2011
Paramount to our understanding of carbohydrates in biology has been the development of methods for analyzing and characterizing the essential features of glycans. This has resulted in a comprehensive appreciation for the various roles of glycans and the pathways associated with their synthesis.
Cosgrave, E.F.J., Struwe, Weston B., Kattla, J.J., Campbell, Matthew P., Wormald, M.R., Rudd, P.   +5 more
openaire   +3 more sources

A Holistic 4D Approach to Optimize Intrinsic and Extrinsic Factors Contributing to Variability in Microarray Biosensing in Glycomics

Sensors, 2023
Protein–carbohydrate interactions happen to be a crucial facet of biology, discharging a myriad of functions. Microarrays have become a premier choice to discern the selectivity, sensitivity and breadth of these interactions in a high-throughput manner ...
Paras H. Kundalia, Lucia Pažitná, Kristína Kianičková, Eduard Jáné, Lenka Lorencová, Jaroslav Katrlík   +5 more
doaj   +1 more source