Results 41 to 50 of about 8,797 (182)

Glycomics

, 2011
Paramount to our understanding of carbohydrates in biology has been the development of methods for analyzing and characterizing the essential features of glycans. This has resulted in a comprehensive appreciation for the various roles of glycans and the pathways associated with their synthesis.
Cosgrave, E.F.J., Struwe, Weston B., Kattla, J.J., Campbell, Matthew P., Wormald, M.R., Rudd, P.   +5 more
openaire   +3 more sources

Bovine Milk Glycome [PDF]

Journal of Dairy Science, 2008
Bovine milk oligosaccharides have several potentially important biological activities including the prevention of pathogen binding to the intestinal epithelial and as nutrients for beneficial bacteria. It has been suggested that milk oligosaccharides are an important source of complex carbohydrates as supplements for the food and the pharmaceutical ...
N, Tao, E J, DePeters, S, Freeman, J B, German, R, Grimm, C B, Lebrilla   +5 more
openaire   +2 more sources

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

The Challenge and Promise of Glycomics

Chemistry & Biology, 2014
Glycomics is a broad and emerging scientific discipline focused on defining the structures and functional roles of glycans in biological systems. The staggering complexity of the glycome, minimally defined as the repertoire of glycans expressed in a cell or organism, has resulted in many challenges that must be overcome; these are being addressed by ...
Cummings, Richard D., Pierce, J. Michael   +1 more
openaire   +2 more sources

High-Throughput Glycomic Methods

Chemical Reviews, 2022
Glycomics aims to identify the structure and function of the glycome, the complete set of oligosaccharides (glycans), produced in a given cell or organism, as well as to identify genes and other factors that govern glycosylation. This challenging endeavor requires highly robust, sensitive, and potentially automatable analytical technologies for the ...
Irena Trbojević-Akmačić, Guinevere S. M. Lageveen-Kammeijer, Bram Heijs, Tea Petrović, Helena Deriš, Manfred Wuhrer, Gordan Lauc   +6 more
openaire   +4 more sources

Parenteral Vaccination with a Super Immunogen Targeting M-Protein Provides Unprecedented Protection Against Group A Streptococcus (StrepA) Respiratory Infections

Proceedings
Rheumatic heart disease (RHD) is a devastating consequence of group A streptococcus (StrepA) infections, being associated with 15 [...]
Victoria Ozberk, Christie Short, Ailin Lepletier, Ainslie Calcutt, Khushi Jain, Simone Reynolds, Aroon Supramaniam, Jamie-lee Mills, Jessica Dooley, Jacqualine Kaden, Michael F. Good, Manisha Pandey   +11 more
doaj   +1 more source

Agricultural and environmental drivers of variation in the composition of food crops: A scoping review

PLANTS, PEOPLE, PLANET, EarlyView.
Agricultural management and environmental conditions influence the biochemical composition of food crops; however, the specific drivers of this variation remain insufficiently understood, despite their importance for climate change adaptation and human health.
Kat Morgan, Teresa Warne, Sahar Toulabi, Fangzhou Li, Amanda Birnbaum, Shawn Ehlers Cheang, Cheng‐Yu Weng, Warangkana Srichamnong, Simab Kanwal, Linda Nana Esi Aduku, Charles Apprey, Kifle Habte Balcha, Herman Erick Lutterodt, Madeleine McGuinness, Bo Wallace, Layla Manoochehri, Alex C. McAlvay, Mary Ann Nunoo, Pearl Boamah Agyekum, Reginald A. Annan, Charlene van Buiten, Mariana Barboza, John de la Parra, Selena Ahmed, Sarah Brinkley   +24 more
wiley   +1 more source

A Serum N‐Glycan Ratio Associated With Disease Severity and Treatment Response in Psoriasis

The Journal of Dermatology, EarlyView.
ABSTRACT Psoriasis is a chronic, immune‐mediated inflammatory disease with heterogeneous manifestations. Reliable biomarkers reflecting disease severity and treatment response remain limited. Glycans—carbohydrate structures attached to proteins and lipids—play key roles in biological processes, contributing to functional specificity.
Kentarou Nishimura, Noritaka Oyama, Takumi Hasegawa, Hiroshi Kasamatsu, Takenao Chino, Takahiro Tokunaga, Kiyoshi Higashi, Koichi Saito, Keita Yamada, Minoru Hasegawa   +9 more
wiley   +1 more source

A focused microarray approach to functional glycomics: transcriptional regulation of the glycome [PDF]

Glycobiology, 2005
Glycosylation is the most common posttranslational modification of proteins, yet genes relevant to the synthesis of glycan structures and function are incompletely represented and poorly annotated on the commercially available arrays. To fill the need for expression analysis of such genes, we employed the Affymetrix technology to develop a focused and ...
Elena M, Comelli, Steven R, Head, Tim, Gilmartin, Thomas, Whisenant, Stuart M, Haslam, Simon J, North, Nyet-Kui, Wong, Takashi, Kudo, Hisashi, Narimatsu, Jeffrey D, Esko, Kurt, Drickamer, Anne, Dell, James C, Paulson   +12 more
openaire   +2 more sources

One Week Exposure to a Somatostatin Receptor 2 Antagonist (SSTR2a) Enhances Glucagon Counterregulation to Insulin‐Induced Hypoglycaemia and Does Not Worsen Glycemia in a Male Rat Model of Insulin‐Requiring Type 2 Diabetes

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Introduction Administration of a somatostatin receptor 2 antagonist (SSTR2a) increases glucagon responsiveness to hypoglycaemia in insulin‐treated type 2 diabetes (T2D), but the durability of this effect and the impact of repeated SSTR2a dosing on overall glycaemia in T2D are unclear.
Ninoschka C. D'Souza, Emily G. Hoffman, Sara C. Atherley, Sabrina Champsi, Nadia Aleali, Richard T. Liggins, Owen Chan, Michael C. Riddell   +7 more
wiley   +1 more source