Results 61 to 70 of about 15,452 (231)

IgG Glycome in Colorectal Cancer [PDF]

Clinical Cancer Research, 2016
Abstract Purpose: Alternative glycosylation has significant structural and functional consequences on IgG and consequently also on cancer immunosurveillance. Because of technological limitations, the effects of highly heritable individual variations and the differences in the dynamics of changes in IgG glycosylation on colorectal ...
Vučković, Frano, Theodoratou, Evropi, Thaçi, Kujtim, Timofeeva, Maria, Vojta, Aleksandar, Štambuk, Jerko, Pučić-Baković, Maja, Rudd, Pauline M., Đerek, Lovorka, Servis, Dražen, Wennerström, Annika, Farrington, Susan M., Perola, Markus, Aulchenko, Yurii, Dunlop, Malcolm G., Campbell, Harry, Lauc, Gordan   +16 more
openaire   +4 more sources

Hierarchical Channeled Graphitized Nanoarchitecture as a Diagnostic Platform for Maternal Fever Warning

Advanced Science, EarlyView.
This study presents a hierarchically channeled graphitized nanoarchitecture (HPGC‐Z67) as a novel nano‐diagnostic platform. It enables sensitive and efficient N‐glycan extraction from plasma, significantly reducing processing time and cost. The platform identifies pivotal N‐glycans to accurately differentiate between infectious and non‐infectious ...
Yiwen Lin, Ning Li, Heyuhan Zhang, Xufang Hu, Zhiqiang Liu, Chunhui Deng   +5 more
wiley   +1 more source

Glycointeractome of Neisseria gonorrhoeae: Identification of Host Glycans Targeted by the Gonococcus To Facilitate Adherence to Cervical and Urethral Epithelial Cells

mBio, 2019
Neisseria gonorrhoeae is a significant threat to global health for which a vaccine and novel treatment options are urgently needed. Glycans expressed by human cells are commonly targeted by pathogens to facilitate interactions with the host, and thus ...
Evgeny A. Semchenko, Arun V. Everest-Dass, Freda E.-C. Jen, Tsitsi D. Mubaiwa, Christopher J. Day, Kate L. Seib   +5 more
doaj   +1 more source

Dynamic Shifts in ER–Plasma Membrane Junctions Signaling Define Pro‐Metastatic N‐Glycosylation and Predict Prostate Cancer Progression

Advanced Science, EarlyView.
Prostate cancer remains a leading cause of male cancer death, yet screening cannot reliably identify aggressive disease, underscoring the need for tissue biomarkers. It is shown that primary tumors increase ER–plasma membrane junction signaling via STIM1/ORP5, whereas metastasis features their loss, Golgi dispersal, and rapid conversion of high‐mannose
Amanda J. Macke, Tania Kamal, Taylor E. Divita, Artem N. Pachikov, Chad A. LaGrange, Rajesh Ravichandran, Martha Morton, Robert Powers, Haowen Qiu, Jean‐Jack M. Riethoven, Colm Morrissey, Melinda Wojtkiewicz, Rebekah L. Gundry, Carol A. Casey, Armen Petrosyan   +14 more
wiley   +1 more source

Glycoproteomic and glycomic databases [PDF]

Clinical Proteomics, 2014
Protein glycosylation serves critical roles in the cellular and biological processes of many organisms. Aberrant glycosylation has been associated with many illnesses such as hereditary and chronic diseases like cancer, cardiovascular diseases, neurological disorders, and immunological disorders. Emerging mass spectrometry (MS) technologies that enable
Baycin Hizal, Deniz, Wolozny, Daniel, Colao, Joseph, Jacobson, Elena, Tian, Yuan, Krag, Sharon S, Betenbaugh, Michael J, Zhang, Hui   +7 more
openaire   +2 more sources

Sustainable Phosphorylated Cellulose Nanocrystals: A Dual‐Affinity Platform for High‐Efficiency Enrichment of Intact Glycopeptides and Phosphopeptides

Advanced Science, EarlyView.
AAA ABSTRACT Protein glycosylation and phosphorylation are critical post‐translational modifications (PTMs) governing nearly all cellular functions, yet their analysis remains challenging due to reliance on costly and unsustainable enrichment materials.
Jiaying Li, Wuming Fan, Xuyang Yue, Dongdong Wang, Xiangyu Tang, Zhuo Zhang, Yonggui Wang, Yanjun Xie, Mingliang Ye, Hongqiang Qin   +9 more
wiley   +1 more source

Protein modification and maintenance systems as biomarkers of ageing [PDF]

, 2015
Changes in the abundance and post-translational modification of proteins and accumulation of some covalently modified proteins have been proposed to represent hallmarks of biological ageing.
Friguet, Bertrand, Gonos, Efstathios S, Libert, Claude, Petropoulos, Isabelle, Santos, Alexander Navarrete, Simm, Andreas, Vanhooren, Valerie, Voutetakis, Konstantinos   +7 more
core   +4 more sources

CSF‐Compartmentalized Antibody Glycoprofiles in NMDAR Encephalitis Associate with Etiology and Functional Recovery

Annals of Neurology, EarlyView.
Objective To characterize Fc‐glycosylation profiles in patients with anti‐N‐methyl‐D‐aspartate receptor encephalitis (NMDARe) and assess their association with antibody compartmentalization (cerebrospinal fluid [CSF] vs serum), disease triggers (viral, tumor‐related or idiopathic), and 1‐year outcomes.
Laura Marmolejo, Claudia Papi, Chiara Milano, Esther Aguilar, Estibaliz Maudes, Ivana Duvnjak Orešković, Jerko Štambuk, Maja Pučić‐Baković, Gemma Olivé‐Cirera, Elianet Fonseca, Mar Guasp, Eugenia Martinez‐Hernandez, Helena Ariño, Takahiro Iizuka, Thais Armangué, Josep Dalmau, Marianna Spatola   +16 more
wiley   +1 more source

Parenteral Vaccination with a Super Immunogen Targeting M-Protein Provides Unprecedented Protection Against Group A Streptococcus (StrepA) Respiratory Infections

Proceedings
Rheumatic heart disease (RHD) is a devastating consequence of group A streptococcus (StrepA) infections, being associated with 15 [...]
Victoria Ozberk, Christie Short, Ailin Lepletier, Ainslie Calcutt, Khushi Jain, Simone Reynolds, Aroon Supramaniam, Jamie-lee Mills, Jessica Dooley, Jacqualine Kaden, Michael F. Good, Manisha Pandey   +11 more
doaj   +1 more source

Extending Tlusty's method to the glycome: Tuning the repertoire of glycan determinants [PDF]

, 2011
We apply Tlusty's information-theoretic analysis of the genetic code to the glycome, using a cognitive paradigm in which external information sources constrain and tune the glycan code error network, in the context of available metabolic energy. The
Deborah Wallace, Rodrick Wallace
core   +1 more source