Results 71 to 80 of about 11,104 (213)

Calcium and phosphorylation coordination is a novel mechanism that stabilises protein-complexes during HIV assembly

Journal of Biomedical Science
Background Calcium (Ca2+) signalling and phosphorylation are independent mechanisms that regulate diverse biological processes. It is, however, not appreciated that a normal function of phospho-mimic amino acids (aspartate/glutamate) is to interact with ...
Erwan Brémaud, Biswa Prasanna Mishra, Ablikim Baqi, Veronika Masic, Thibaut Flipo, Arun Everest-Dass, Lauren Hartley-Tassell, Paul R. Gorry, Thomas Ve, Belinda L. Spillings, Johnson Mak   +10 more
doaj   +1 more source

Bacteriophage P22 Virus‐Like Particles as Nanoscale Protein Scaffolds for Plant Synthetic Biology

Plant Biotechnology Journal, EarlyView.
ABSTRACT Advancing the utility of plant synthetic biology requires the continued development of protein engineering tools. Self‐assembling protein compartments, such as virus‐like particles (VLPs), provide versatile scaffolds for synthetic biology. However, few plant‐expressed VLPs have demonstrated broad amenability to protein engineering, restricting
Maxim D. Harding, Mark A. Jackson, Edward K. Gilding, David J. Craik, Frank Sainsbury, Nicole Lawrence   +5 more
wiley   +1 more source

Complementary Breath Profiling Using eNose and Gas Chromatography‐Mass Spectrometry for Noninvasive Triage of Indeterminate Pulmonary Nodules

MedComm, Volume 7, Issue 10, October 2026.
Flow diagram illustrating participant inclusion and exclusion for the eNose and GC‐MS analyses. Of the 98 prospectively enrolled participants, 79 were eligible for the eNose analysis after the exclusion of 14 participants because of procedural or eligibility issues, four without breath samples, and one without a valid eNose recording.
Waqar Ahmed Afridi, Gunter Hartel, Xi Zhang, David Pass, David Fielding, Chamindie Punyadeera   +5 more
wiley   +1 more source

Sialic acid and platelet count regulation: Implications in immune thrombocytopenia

Research and Practice in Thrombosis and Haemostasis, 2022
Platelets are blood components that survive in circulation for 7 to 10 days in humans. Thus, platelet production by bone marrow (BM) megakaryocytes (MKs), and their removal from the blood circulation is precisely orchestrated to maintain an average ...
Melissa M. Lee‐Sundlov, Leonardo Rivadeneyra, Hervé Falet, Karin M. Hoffmeister   +3 more
doaj   +1 more source

Using Synthetic Glycans to Investigate Anti‐Glycan Antibodies and Explore Their Medical Potential

Angewandte Chemie International Edition, Volume 65, Issue 39, 21 September 2026.
Anti‐glycan antibodies are essential in health and disease. Access to novel glycan structures paves the way for progress in antibody profiling for biomarker discovery, antibody development, and vaccine design. We summarize the strategies to synthesize and utilize synthetic glycans for the development and application of anti‐glycan antibodies in basic ...
Fabienne Weber, Aina Valenti, Jiří Ledvinka, Oren Moscovitz, Peter H. Seeberger   +4 more
wiley   +1 more source

The Moraxella catarrhalis phase-variable DNA methyltransferase ModM3 is an epigenetic regulator that affects bacterial survival in an in vivo model of otitis media

BMC Microbiology, 2019
Background Moraxella catarrhalis is a leading cause of otitis media (OM) and chronic obstructive pulmonary disease (COPD). M. catarrhalis contains a Type III DNA adenine methyltransferase (ModM) that is phase-variably expressed (i.e., its expression is ...
Luke V. Blakeway, Aimee Tan, Joseph A. Jurcisek, Lauren O. Bakaletz, John M. Atack, Ian R. Peak, Kate L. Seib   +6 more
doaj   +1 more source

Conference Report: MSB 2026—International Symposium on Microscale Separations and Bioanalysis With Special Focus on Gel and Polymer Network‐Based Separations

ELECTROPHORESIS, EarlyView.
Andras Guttman
wiley   +1 more source

Nonpolar and Polar Lipids Composition in Recombinant Chinese Hamster Ovary Cells by Nile Red Staining Flow Cytometry

European Journal of Lipid Science and Technology, Volume 128, Issue 9, September 2026.
Cellular lipid composition is a dynamic process. Understanding it is important to improve recombinant protein production. Molecules with solvatochromic properties allow the determination of lipids of different polarities by flow cytometry and offer a useful method for monitoring lipids during different phases of cell growth in bioprocesses.
Francisco E. López‐Salas, Enrique García‐Hernández, Francisco Gasteazoro, Emiliano Balderas‐Ramírez, Octavio T. Ramírez, Georgina I. López‐Cortés, Helgi Jung‐Cook, Emilio Rojas, Mauricio A. Trujillo‑Roldán, Norma A. Valdez‑Cruz   +9 more
wiley   +1 more source

Glycomics, glycoproteomics and the immune system

, 2012
Glycomics and glycoproteomics have become indispensible tools in the study of glycoconjugates. Mass spectrometry based methods are standardly used to study the proteome and/or glycome and these approaches are capable of providing both, qualitative and ...
Kolarich, D., Seeberger, P. H., Kolarich, Daniel, Lepenies, B., Seeberger, Peter H, Lepenies, Bernd, Seeberger, Peter H., Seeberger, P.   +7 more
core   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, Volume 2, Issue 3, September 2026.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source