Results 71 to 80 of about 15,452 (231)
Ferrets exclusively synthesize Neu5Ac and express naturally humanized influenza A virus receptors [PDF]
, 2014 Mammals express the sialic acids N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc) on cell surfaces, where they act as receptors for pathogens, including influenza A virus (IAV). Neu5Gc is synthesized from Neu5Ac by the enzyme
Böhm, Raphael +14 more
core +1 more source
Sample preparation methods for N-glycomics
Advances in Sample Preparation, 2022 Aberrant glycosylation has been associated with the human disease since it involves crucial mechanisms such as tumor onset, development, and progression.
H. Mehmet Kayili +3 more
doaj +1 more source
Discussion on the paper ‘Statistical contributions to bioinformatics: Design, modelling, structure learning and integration’ by Jeffrey S. Morris and Veerabhadran Baladandayuthapani [PDF]
, 2017 Bioinformatics is an important research area for statisticians. This discussion provides some additional topics to the paper, namely on statistical contributions to detect differential expressed genes, for protein structure prediction, and for the ...
Aitchison J +5 more
core +1 more source
The FASEB Journal, 2021 Eukaryotic Vertebrate host glycosylation machinery has been subject to immense evolutionary pressure. Besides, being crucial for host sustenance, glyco‐epitopes are also key‐regulators of inter‐species pathogen transmission. Significant evolutionary events such as loss of N‐glycolyl neuraminic acid (Neu5Gc) or alpha Galactose (α‐Gal) epitopes in ...
Abarna V. M. Murugan +13 more
openaire +1 more source
mBio, 2022 Ross River virus (RRV) is the major mosquito-borne virus in the South Pacific region. RRV infections are characterized by arthritic symptoms, which can last from several weeks to months.
Xiang Liu +7 more
doaj +1 more source
Glycomics and disease markers [PDF]
Current Opinion in Chemical Biology, 2009 Glycomics is the comprehensive study of all glycans expressed in biological systems. The biosynthesis of glycan relies on a number of highly competitive processes involving glycosyl transferases. Glycosylation is therefore highly sensitive to the biochemical environment and has been implicated in many diseases including cancer.
Hyun Joo, An +3 more
openaire +2 more sources
BMEMat, EarlyView.This Perspective explores the emerging landscape of cell membrane‐coated nanoparticles (CM‐NPs) as intelligent, immune‐compatible platforms for cancer therapy. Highlighting design strategies, translational challenges, and competitive positioning, it outlines how integrating biomimetic targeting with advanced analytical and manufacturing tools could ...
A. K. M. M. Alam +4 more
wiley +1 more source
Progress of metabolomics‐centric multi‐omics research in medicine
iMetaOmics, EarlyView.The graphical abstract illustrates a holistic roadmap for metabolomics‐centric multi‐omics integration in medical research. The upper panel depicts the technological transition from traditional bulk analysis to high‐resolution single‐cell and spatial methodologies, specifically addressing inherent challenges such as molecular complexity and dynamic ...
Ziyi Wang +6 more
wiley +1 more source
BMC Microbiology, 2019 Background Moraxella catarrhalis is a leading cause of otitis media (OM) and chronic obstructive pulmonary disease (COPD). M. catarrhalis contains a Type III DNA adenine methyltransferase (ModM) that is phase-variably expressed (i.e., its expression is ...
Luke V. Blakeway +6 more
doaj +1 more source
Sialic acid and platelet count regulation: Implications in immune thrombocytopenia
Research and Practice in Thrombosis and Haemostasis, 2022 Platelets are blood components that survive in circulation for 7 to 10 days in humans. Thus, platelet production by bone marrow (BM) megakaryocytes (MKs), and their removal from the blood circulation is precisely orchestrated to maintain an average ...
Melissa M. Lee‐Sundlov +3 more
doaj +1 more source