Pneumococcal Phasevarions Control Multiple Virulence Traits, Including Vaccine Candidate Expression [PDF]
Microbiology Spectrum, 2022 Streptococcus pneumoniae is the most common cause of bacterial illness worldwide. Current vaccines based on the polysaccharide capsule are only effective against a limited number of the >100 capsular serotypes.
Mark Von Itzstein +2 more
exaly +11 more sources
Phase-variable Type I methyltransferase M.NgoAV from Neisseria gonorrhoeae FA1090 regulates phasevarion expression and gonococcal phenotype [PDF]
Frontiers in Microbiology, 2022 The restriction-modification (RM) systems are compared to a primitive, innate, prokaryotic immune system, controlling the invasion by foreign DNA, composed of methyltransferase (MTase) and restriction endonuclease.
Agnieszka Kwiatek +2 more
exaly +9 more sources
The ModA2 Phasevarion of nontypeable Haemophilus influenzae Regulates Resistance to Oxidative Stress and Killing by Human Neutrophils [PDF]
Scientific Reports, 2017 Nontypeable Haemophilus influenzae (NTHI) is the causative agent of multiple respiratory tract infections. Several human pathogens, including NTHI, possess a novel genetic system, termed the phasevarion, which mediates a rapid and reversible change in ...
Frank Robledo-Ávila +2 more
exaly +10 more sources
Adherence of Nontypeable Haemophilus influenzae to Cells and Substrates of the Airway Is Differentially Regulated by Individual ModA Phasevarions [PDF]
Microbiology Spectrum, 2023 Adherence of nontypeable Haemophilus influenzae (NTHi) to the host airway is an essential initial step for asymptomatic colonization of the nasopharynx, as well as development of disease.
Lauren Bakaletz +2 more
exaly +11 more sources
Origin of the Diversity in DNA Recognition Domains in Phasevarion Associated modA Genes of Pathogenic Neisseria and Haemophilus influenzae [PDF]
PLoS ONE, 2012 Phase variable restriction-modification (R-M) systems have been identified in a range of pathogenic bacteria. In some it has been demonstrated that the random switching of the mod (DNA methyltransferase) gene mediates the coordinated expression of ...
Michael P Jennings +2 more
exaly +12 more sources
The Moraxella catarrhalis phase-variable DNA methyltransferase ModM3 is an epigenetic regulator that affects bacterial survival in an in vivo model of otitis media [PDF]
BMC Microbiology, 2019 Background Moraxella catarrhalis is a leading cause of otitis media (OM) and chronic obstructive pulmonary disease (COPD). M. catarrhalis contains a Type III DNA adenine methyltransferase (ModM) that is phase-variably expressed (i.e., its expression is ...
Ian Peak, Lauren Bakaletz, Kate Seib
exaly +7 more sources
Phasevarions in Haemophilus influenzae biogroup aegyptius control expression of multiple proteins [PDF]
Microbiology Spectrum, 2023 Haemophilus influenzae biogroup aegyptius is the causative agent of Brazilian purpuric fever (BPF), an invasive disease with high mortality, that sporadically manifests in children previously suffering conjunctivitis. Though strains of H.
Michael P Jennings +2 more
exaly +8 more sources
The Capricious Nature of Bacterial Pathogens: Phasevarions and Vaccine Development [PDF]
Frontiers in Immunology, 2016 Infectious diseases are a leading cause of morbidity and mortality worldwide, and vaccines are one of the most successful and cost-effective tools for disease prevention.
Aimee Tan +3 more
doaj +10 more sources
A Bacterial Epigenetic Switch in Non-typeable Haemophilus influenzae Modifies Host Immune Response During Otitis Media [PDF]
Frontiers in Cellular and Infection Microbiology, 2020 Non-typeable Haemophilus influenzae (NTHi) causes multiple diseases of the human airway and is a predominant bacterial pathogen of acute otitis media and otitis media in which treatment fails.
Frank Robledo-Ávila +2 more
exaly +5 more sources
Systematic Analysis of REBASE Identifies Numerous Type I Restriction-Modification Systems with Duplicated, Distinct
mSystems, 2020 N6-Adenine DNA methyltransferases associated with some Type I and Type III restriction-modification (R-M) systems are able to undergo phase variation, randomly switching expression ON or OFF by varying the length of locus-encoded simple sequence repeats (
John M. Atack +6 more
doaj +3 more sources