mSphere, 2017 Streptococcus pneumoniae (pneumococcus) is a leading human pathogen that can cause serious localized and invasive diseases. Pneumococci can undergo a spontaneous and reversible phase variation that is reflected in colony opacity and which allows the ...
Melissa B. Oliver +4 more
doaj +3 more sources
Actinobacillus pleuropneumoniae encodes multiple phase-variable DNA methyltransferases that control distinct phasevarions. [PDF]
Nucleic Acids Res, 2023 Actinobacillus pleuropneumoniae is the cause of porcine pleuropneumonia, a severe respiratory tract infection that is responsible for major economic losses to the swine industry. Many host-adapted bacterial pathogens encode systems known as phasevarions (
Nahar N +16 more
europepmc +7 more sources
Epigenetic Regulation Alters Biofilm Architecture and Composition in Multiple Clinical Isolates of Nontypeable Haemophilus influenzae [PDF]
MBio, 2018 Biofilms play a critical role in the colonization, persistence, and pathogenesis of many human pathogens. Multiple mucosa-associated pathogens have evolved a mechanism of rapid adaptation, termed the phasevarion, which facilitates a coordinated ...
Lauren Bakaletz +2 more
exaly +4 more sources
High-depth RNA-Seq data sets to investigate the differences in gene expression mediated by phasevarions in non-typeable Haemophilus influenzae. [PDF]
Microbiol Resour Announc, 2023 Non-typeable Haemophilus influenzae (NTHi) is a major bacterial pathogen of the human airway. We report high-depth coverage RNA-Seq data from prototype NTHi strains 723 and R2866, encoding two of the most common phase-variable ModA alleles found in NTHi ...
Atack JM +3 more
europepmc +5 more sources
A phasevarion controls multiple virulence traits, including expression of vaccine candidates, in Streptococcus pneumoniae [PDF]
bioRxiv, 2022 Streptococcus pneumoniae is the most common cause of bacterial illness worldwide. Current vaccines based on the polysaccharide capsule (PCV-13 and PPSV-23) are only effective against a limited number of the >100 capsular serotypes.
Zachary N. Phillips +12 more
semanticscholar +2 more sources
Streptococcus suis Encodes Multiple Allelic Variants of a Phase-Variable Type III DNA Methyltransferase, ModS, That Control Distinct Phasevarions. [PDF]
mSphere, 2021 Streptococcus suis is a causative agent of meningitis, polyarthritis, and polyserositis in swine, and it is a major cause of zoonotic meningitis in humans. Here, we investigate epigenetic gene regulation in S.
Tram G +7 more
europepmc +9 more sources
Streptococcus suis contains multiple phase-variable methyltransferases that show a discrete lineage distribution. [PDF]
Nucleic Acids Res, 2018 Streptococcus suis is a major pathogen of swine, responsible for a number of chronic and acute infections, and is also emerging as a major zoonotic pathogen, particularly in South-East Asia. Our study of a diverse population of S.
Atack JM +10 more
europepmc +5 more sources
mBio, 2018 Biofilms play a critical role in the colonization, persistence, and pathogenesis of many human pathogens. Multiple mucosa-associated pathogens have evolved a mechanism of rapid adaptation, termed the phasevarion, which facilitates a coordinated ...
Kenneth L. Brockman +7 more
doaj +2 more sources
Phase variation of DNA methyltransferases and the regulation of virulence and immune evasion in the pathogenic Neisseria. [PDF]
Pathogens and Disease, 2017 The pathogenic Neisseria provide textbook examples of phase variation: the high frequency, random and reversible switching of gene expression. Typically, phase variable gene expression is observed in genes required for the expression of surface proteins ...
Kate L. Seib +4 more
semanticscholar +3 more sources
Phasevarions Mediate Epigenetic Regulation of Antimicrobial Susceptibility in Neisseria meningitidis [PDF]
Antimicrobial Agents and Chemotherapy, 2014 ABSTRACT Phase variation is a common feature of host-adapted bacterial pathogens such as Neisseria meningitidis . Recently, we reported that this rapid on/off switching of gene expression occurs in DNA methyltransferases, altering expression in multiple genes via changes in global methylation.
F. Jen, Kate L. Seib, M. Jennings
semanticscholar +4 more sources