Results 21 to 30 of about 189 (85)

Streptococcus suis contains multiple phase-variable methyltransferases that show a discrete lineage distribution. [PDF]

open access: yesNucleic Acids Res, 2018
Streptococcus suis is a major pathogen of swine, responsible for a number of chronic and acute infections, and is also emerging as a major zoonotic pathogen, particularly in South-East Asia. Our study of a diverse population of S.
Atack JM   +10 more
europepmc   +3 more sources

Selective and non‐selective bottlenecks as drivers of the evolution of hypermutable bacterial loci

open access: yesMolecular Microbiology, Volume 113, Issue 3, Page 672-681, March 2020., 2020
Bottlenecks produce dramatic reductions in the genetic diversity of bacterial populations. Bottleneck events can be selective or non‐selective and occur frequently, particularly during transmission between hosts. Multiple mutational strategies have evolved in bacteria that can regenerate genetic diversity within surviving populations following a major ...
Megan De Ste Croix   +5 more
wiley   +1 more source

Epigenetic Regulation Alters Biofilm Architecture and Composition in Multiple Clinical Isolates of Nontypeable Haemophilus influenzae

open access: yesmBio, 2018
Biofilms play a critical role in the colonization, persistence, and pathogenesis of many human pathogens. Multiple mucosa-associated pathogens have evolved a mechanism of rapid adaptation, termed the phasevarion, which facilitates a coordinated ...
Kenneth L. Brockman   +7 more
doaj   +1 more source

Data_Sheet_1_Phase-variable Type I methyltransferase M.NgoAV from Neisseria gonorrhoeae FA1090 regulates phasevarion expression and gonococcal phenotype.PDF

open access: yes, 2022
The restriction-modification (RM) systems are compared to a primitive, innate, prokaryotic immune system, controlling the invasion by foreign DNA, composed of methyltransferase (MTase) and restriction endonuclease.
Natalia Matczynska (13901700)   +5 more
core   +1 more source

Mechanistic and functional analysis of Cj0031: a phase variable methyltransferase in Campylobacter jejuni

open access: yes, 2013
Campylobacter jejuni constitutes the major cause of food-borne diarrheal disease in developed countries. The genome of this species comprises many surface genes having mononucleotide repeat tracts (PolyG/PolyC) which undergo reversible switching between ...
Awais Anjum (7636874)
core   +6 more sources

Image_1_Phase-variable Type I methyltransferase M.NgoAV from Neisseria gonorrhoeae FA1090 regulates phasevarion expression and gonococcal phenotype.TIF

open access: yes, 2022
The restriction-modification (RM) systems are compared to a primitive, innate, prokaryotic immune system, controlling the invasion by foreign DNA, composed of methyltransferase (MTase) and restriction endonuclease.
Natalia Matczynska (13901700)   +5 more
core   +1 more source

Comparative genome analysis reveals important genetic differences among serotype O1 and serotype O2 strains of Y. ruckeri and provides insights into host adaptation and virulence

open access: yesMicrobiologyOpen, Volume 6, Issue 4, August 2017., 2017
The comparative analysis of the genome sequences of five Y. ruckeri strains (150, CSF007‐82, ATCC29473, Big Creek 74, and SC09) isolated from different hosts and classified into different serotypes revealed important genetic differences between the genomes analyzed. These could provide insights into the understanding of the virulence and niche adaptive
Desirée Cascales   +3 more
wiley   +1 more source

How the Knowledge of Interactions between Meningococcus and the Human Immune System Has Been Used to Prepare Effective Neisseria meningitidis Vaccines

open access: yesJournal of Immunology Research, Volume 2015, Issue 1, 2015., 2015
In the last decades, tremendous advancement in dissecting the mechanisms of pathogenicity of Neisseria meningitidis at a molecular level has been achieved, exploiting converging approaches of different disciplines, ranging from pathology to microbiology, immunology, and omics sciences (such as genomics and proteomics).
R. Gasparini   +8 more
wiley   +1 more source

Themes and Variations: Regulation of RpoN‐Dependent Flagellar Genes across Diverse Bacterial Species

open access: yesScientifica, Volume 2014, Issue 1, 2014., 2014
Flagellar biogenesis in bacteria is a complex process in which the transcription of dozens of structural and regulatory genes is coordinated with the assembly of the flagellum. Although the overall process of flagellar biogenesis is conserved among bacteria, the mechanisms used to regulate flagellar gene expression vary greatly among different ...
Jennifer Tsang   +4 more
wiley   +1 more source

Moraxella catarrhalis Restriction-Modification Systems Are Associated with Phylogenetic Lineage and Disease. [PDF]

open access: yesGenome Biol Evol, 2018
Moraxella catarrhalis is a human-adapted pathogen, and a major cause of otitis media (OM) and exacerbations of chronic obstructive pulmonary disease. The species is comprised of two main phylogenetic lineages, RB1 and RB2/3. Restriction-modification (R-M)
Blakeway LV   +16 more
europepmc   +3 more sources

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