Microbiology, 2019 Phase-variable DNA methyltransferases control the expression of multiple genes via epigenetic mechanisms in a wide variety of bacterial species. These systems are called phasevarions, for phase-variable regulons.
Zachary N. Phillips +4 more
semanticscholar +4 more sources
bioRxiv, 2022 Abstract Adherence of non-typeable Haemophilus influenzae (NTHi) to the host airway is an essential initial step for asymptomatic colonization of the nasopharynx, as well as development of disease. NTHi relies on strict regulation of multiple adhesins for its pathogenesis.
Preeti Garai +5 more
semanticscholar +2 more sources
Random Switching of the ModA11 Type III DNA Methyltransferase of Neisseria meningitidis Regulates Entner-Doudoroff Aldolase Expression by a Methylation Change in the eda Promoter Region. [PDF]
Journal of Molecular Biology, 2020 Phase variable DNA methyltransferases (Mods) mediate epigenetic regulation of gene expression. These phase variable regulons, called phasevarions, have been shown to regulate virulence and immunoevasion in multiple bacterial pathogens.
F. Jen +4 more
semanticscholar +2 more sources
Non-typeable Haemophilus influenzae isolates from patients with chronic obstructive pulmonary disease contain new phase-variable modA methyltransferase alleles controlling phasevarions. [PDF]
Sci Rep, 2019 Phasevarions (phase-variable regulons) are emerging as an important area of bacterial gene regulation. Many bacterial pathogens contain phasevarions, with gene expression controlled by the phase-variable expression of DNA methyltransferases via ...
Atack JM +4 more
europepmc +6 more sources
Specificity of the ModA11, ModA12 and ModD1 epigenetic regulator N6-adenine DNA methyltransferases of Neisseria meningitidis [PDF]
Nucleic Acids Research, 2015 Phase variation (random ON/OFF switching) of gene expression is a common feature of host-adapted pathogenic bacteria. Phase variably expressed N6-adenine DNA methyltransferases (Mod) alter global methylation patterns resulting in changes in gene ...
Kate L. Seib +18 more
semanticscholar +5 more sources
A survey of Type III restriction-modification systems reveals numerous, novel epigenetic regulators controlling phase-variable regulons; phasevarions. [PDF]
Nucleic Acids Res, 2018 Many bacteria utilize simple DNA sequence repeats as a mechanism to randomly switch genes on and off. This process is called phase variation. Several phase-variable N6-adenine DNA-methyltransferases from Type III restriction-modification systems have ...
Atack JM +4 more
europepmc +5 more sources
Moraxella catarrhalis Restriction-Modification Systems Are Associated with Phylogenetic Lineage and Disease. [PDF]
Genome Biol Evol, 2018 Moraxella catarrhalis is a human-adapted pathogen, and a major cause of otitis media (OM) and exacerbations of chronic obstructive pulmonary disease. The species is comprised of two main phylogenetic lineages, RB1 and RB2/3. Restriction–modification (R-M)
Blakeway LV +16 more
europepmc +7 more sources
Moraxella catarrhalis phasevarions [PDF]
, 2021 Moraxella catarrhalis is a human-restricted, Gram-negative, opportunistic bacterial pathogen of the respiratory mucosa. Although frequently found to colonize the nasopharynx asymptomatically, M. catarrhalis is also an important cause of otitis media (OM)
Luke Blakeway
semanticscholar +2 more sources
Broad Conditions Favor the Evolution of Phase-Variable Loci
mBio, 2013 Simple sequence repeat (SSR) tracts produce stochastic on-off switching, or phase variation, in the expression of a panoply of surface molecules in many bacterial commensals and pathogens.
M. E. Palmer +3 more
doaj +2 more sources
Microbial Primer: Phase variation - survival and adaptability by generation of a diverse population. [PDF]
Microbiology (Reading)Phase variation is defined as the rapid and reversible switching of gene expression, and typically occurs in genes encoding surface features in small genome bacterial pathogens.
Fraser AJ, McMahon FE, Atack JM.
europepmc +2 more sources