Results 31 to 40 of about 189 (85)

Phase variation of DNA methyltransferases and the regulation of virulence and immune evasion in the pathogenic Neisseria [PDF]

, 2017
The pathogenic Neisseria provide textbook examples of phase variation: the high frequency, random and reversible switching of gene expression. Typically, phase variable gene expression is observed in genes required for the expression of surface proteins ...
Freda E.-C. Jen, Jennings, Michael P, Tan, Aimee, Seib, Kate, Jennings, Michael, Scott, Adeana, Kate L. Seib, Michael P. Jennings, Scott, Adeana L, Jen, Freda E-C, Jen, Freda, Seib, Kate L, Adeana L. Scott, Aimee Tan   +13 more
core   +1 more source

Streptococcus pneumoniae TIGR4 Phase-Locked Opacity Variants Differ in Virulence Phenotypes

mSphere, 2017
Streptococcus pneumoniae (pneumococcus) is a leading human pathogen that can cause serious localized and invasive diseases. Pneumococci can undergo a spontaneous and reversible phase variation that is reflected in colony opacity and which allows the ...
Melissa B. Oliver, Ankita Basu Roy, Ranjit Kumar, Elliot J. Lefkowitz, W. Edward Swords   +4 more
doaj   +1 more source

DNA methylation assessed by SMRT sequencing is linked to mutations in Neisseria meningitidis isolates [PDF]

, 2015
The Gram-negative bacterium Neisseria meningitidis features extensive genetic variability. To present, proposed virulence genotypes are also detected in isolates from asymptomatic carriers, indicating more complex mechanisms underlying variable ...
Gerd Pluschke, Christoph D. Schmid (72046), Schmid, Christoph D., Mane, Shrikant, Korlach, Jonas, Tyson A. Clark (105783), Katharina Röltgen, Wang, Guilin, Araceli Lamelas, Jonas Korlach (105788), Shrikant Mane, Araceli Lamelas (128475), Christoph D Schmid, Mohamad R Abdul Sater, Clark, Tyson A., Röltgen, Katharina, Gerd Pluschke (7855), Katharina Röltgen (120045), Guilin Wang, Sater, Mohamad R. Abdul, Tyson A Clark, Mohamad R. Abdul Sater (836669), Jonas Korlach, Guilin Wang (37620), Shrikant Mane (106631), Lamelas, Araceli, Pluschke, Gerd   +26 more
core   +1 more source

Moraxella catarrhalis phasevarions

, 2021
Moraxella catarrhalis is a human-restricted, Gram-negative, opportunistic bacterial pathogen of the respiratory mucosa. Although frequently found to colonize the nasopharynx asymptomatically, M. catarrhalis is also an important cause of otitis media (OM)
Blakeway, Luke V
core   +1 more source

Random Switching of the ModA11 Type III DNA Methyltransferase of Neisseria meningitidis Regulates Entner-Doudoroff Aldolase Expression by a Methylation Change in the eda Promoter Region

, 2020
Phase variable DNA methyltransferases (Mods) mediate epigenetic regulation of gene expression. These phase variable regulons, called phasevarions, have been shown to regulate virulence and immunoevasion in multiple bacterial pathogens.
Scott, Adeana L, Jen, Freda E-C, Jennings, Michael P, Seib, Kate L, Tan, Aimee   +4 more
core   +1 more source

Specificity of the ModA11, ModA12 and ModD1 epigenetic regulator N6-adenine DNA methyltransferases of Neisseria meningitidis [PDF]

, 2015
Phase variation (random ON/OFF switching) of gene expression is a common feature of host-adapted pathogenic bacteria. Phase variably expressed N(6)-adenine DNA methyltransferases (Mod) alter global methylation patterns resulting in changes in gene ...
Kumar, Ritesh, Wang, Andrew HJ, Morgan, Richard D., Korlach, Jonas, Rao, Desirazu N., Power, Peter M, Clark, Tyson A, Tan, Aimee, Chen, Li-Tzu, Luyten, Yvette A., Wang, Andrew H-J, Roberts, Richard J, Jen, Freda, Roberts, Richard J., Hill, Dorothea M. C., Wang, Andrew H.-J., Boitano, Matthew, Clark, Tyson A., Jen, Freda EC, Power, Peter, Jennings, Michael P, Rao, Desirazu N, Wu, Hsing-Ju, Seib, Kate, Jennings, Michael, Morgan, Richard D, Scott, Adeana, Luyten, Yvette A, Scott, Adeana L, Jen, Freda E-C, Maiden, Martin C. J., Hill, Dorothea MC, Seib, Kate L, Maiden, Martin CJ   +33 more
core   +3 more sources

Haemophilus influenzae phasevarions have evolved from type III DNA restriction systems into epigenetic regulators of gene expression [PDF]

, 2007
Phase variably expressed ( randomly switching) methyltransferases associated with type III restriction-modification (R-M) systems have been identified in a variety of pathogenic bacteria.
Erwin, AL, Fox, Kate L., Dowideit, Stefanie, Arnold L. Smith, Erwin, Alice L, Fox, KL, Dowideit, SJ, Jennings, Michael P, Srikhanta, YN, Stefanie J. Dowideit, Fox, Kate L, P. Jennings, Michael, Alice L. Erwin, Srikhanta, Yogitha N, Michael P. Jennings, Kate L. Fox, Dowideit, Stefanie J, Smith, Arnold L, L. Smith, Arnold, L. Erwin, Alice, N. Srikhanta, Yogitha, Smith, AL, Jennings, MP, Yogitha N. Srikhanta   +23 more
core   +1 more source

ModM DNA methyltransferase methylome analysis reveals a potential role for Moraxella catarrhalis phasevarions in otitis media [PDF]

, 2014
Moraxella catarrhalis is a significant cause of otitis media and exacerbations of chronic obstructive pulmonary disease. Here, we characterize a phase-variable DNA methyltransferase (ModM), which contains 5'-CAAC-3' repeats in its open reading frame that
Boitano, Matthew, Bakaletz, Lauren O, Korlach, Jonas, Clark, Tyson A., Worboys, Sam R, Power, Peter M, Power, Peter, Bakaletz, Lauren O., Jennings, Michael P, Peak, Ian R, Clark, Tyson A, Peak, Ian, Jennings, Michael, Seib, Kate, Blakeway, Luke, Blakeway, Luke V, Jen, Freda E-C, Jen, Freda, Worboys, Sam, Seib, Kate L, Boitiano, Matthew   +20 more
core   +1 more source

High-depth RNA-Seq data sets to investigate the differences in gene expression mediated by phasevarions in non-typeable Haemophilus influenzae. [PDF]

Microbiol Resour Announc, 2023
Atack JM, Brockman KL, Bakaletz LO, Jennings MP.   +3 more
europepmc   +1 more source

Phase variation and adaptation in bacteria: a 'Red Queen's Race' [PDF]

, 2011
In nature, bacteria are constantly exposed to many stressful conditions of life. This is particularly true of pathogens. Survival and adaptation under stressful conditions demand multiple strategies, genetic as well as phenotypic. Bacteria have many, pre-
Jayaraman, R.
core   +2 more sources