Results 1 to 10 of about 6,861,845 (296)

Slipped-strand mispairing within a polycytidine tract in transcriptional regulator mga leads to M protein phase variation and Mga length polymorphism in Group A Streptococcus [PDF]

Frontiers in Microbiology, 2023
The M protein, a major virulence factor of Group A Streptococcus (GAS), is regulated by the multigene regulator Mga. An unexplained phenomena frequently occurring with in vitro genetic manipulation or culturing of M1T1 GAS strains is the loss of M ...
Benfang Lei, Tracey S. Hanks, Yunjuan Bao, Mengyao Liu   +3 more
doaj   +2 more sources

The Fis Nucleoid Protein Negatively Regulates the Phase Variation fimS Switch of the Type 1 Pilus Operon in Enteropathogenic Escherichia coli [PDF]

Frontiers in Microbiology, 2022
In Escherichia coli the expression of type 1 pili (T1P) is determined by the site-specific inversion of the fimS ON–OFF switch located immediately upstream of major fimbrial subunit gene fimA.
Zeus Saldaña-Ahuactzi, Jorge Soria-Bustos, Verónica I. Martínez-Santos, Jorge A. Yañez-Santos, Ygnacio Martínez-Laguna, María Lilia Cedillo-Ramirez, José L. Puente, Jorge A. Girón   +7 more
doaj   +2 more sources

Stabilizing Genetically Unstable Simple Sequence Repeats in the Campylobacter jejuni Genome by Multiplex Genome Editing: a Reliable Approach for Delineating Multiple Phase-Variable Genes

mBio, 2021
Hypermutable simple sequence repeats (SSRs) are major drivers of phase variation in Campylobacter jejuni. The presence of multiple SSR-mediated phase-variable genes encoding enzymes that modify surface structures, including capsular polysaccharide (CPS ...
Shouji Yamamoto, Sunao Iyoda, Makoto Ohnishi   +2 more
doaj   +1 more source

Phase variations of the summer and winter seasons in the Bohai Sea during the last four decades

Frontiers in Marine Science, 2023
In most coastal oceans, the impacts of global warming on season duration and timing of seasonal transitions remain unknown. To mirror the reality of the ongoing climate change, the summer and winter seasons are redefined using the local water temperature
Chengyi Yuan, Xiaodi Kuang, Jingbo Xu, Ruopeng Li, Chen Wang   +4 more
doaj   +1 more source

An IS-mediated, RecA-dependent, bet-hedging strategy in Burkholderia thailandensis

eLife, 2023
Adaptation to fluctuating environmental conditions is difficult to achieve. Phase variation mechanisms can overcome this difficulty by altering genomic architecture in a subset of individuals, creating a phenotypically heterogeneous population with ...
Lillian C Lowrey, Leslie A Kent, Bridgett M Rios, Angelica B Ocasio, Peggy A Cotter   +4 more
doaj   +1 more source

Bacterial DNA methyltransferase: A key to the epigenetic world with lessons learned from proteobacteria

Frontiers in Microbiology, 2023
Epigenetics modulates expression levels of various important genes in both prokaryotes and eukaryotes. These epigenetic traits are heritable without any change in genetic DNA sequences. DNA methylation is a universal mechanism of epigenetic regulation in
Qun Gao, Qun Gao, Shuwei Lu, Shuwei Lu, Yuwei Wang, Longgui He, Longgui He, Mingshu Wang, Mingshu Wang, Mingshu Wang, Renyong Jia, Renyong Jia, Renyong Jia, Shun Chen, Shun Chen, Shun Chen, Dekang Zhu, Dekang Zhu, Dekang Zhu, Mafeng Liu, Mafeng Liu, Mafeng Liu, Xinxin Zhao, Xinxin Zhao, Xinxin Zhao, Qiao Yang, Qiao Yang, Qiao Yang, Ying Wu, Ying Wu, Ying Wu, Shaqiu Zhang, Shaqiu Zhang, Shaqiu Zhang, Juan Huang, Juan Huang, Juan Huang, Sai Mao, Sai Mao, Sai Mao, Xumin Ou, Xumin Ou, Xumin Ou, Di Sun, Di Sun, Di Sun, Bin Tian, Bin Tian, Bin Tian, Anchun Cheng, Anchun Cheng, Anchun Cheng   +51 more
doaj   +1 more source

Comparative Analysis of Streptococcus pneumoniae Type I Restriction-Modification Loci: Variation in hsdS Gene Target Recognition Domains

Pathogens, 2020
Streptococcus pneumoniae (pneumococcus) is a respiratory commensal pathogen that causes a range of infections, particularly in young children and the elderly.
Melissa B. Oliver, W. Edward Swords
doaj   +1 more source

Phage-Resistant Phase-Variant Sub-populations Mediate Herd Immunity Against Bacteriophage Invasion of Bacterial Meta-Populations

Frontiers in Microbiology, 2019
Hypermutable loci are widespread in bacteria as mechanisms for rapid generation of phenotypic diversity within a population that enables survival of fluctuating, often antagonistic, selection pressures. Localized hypermutation can mediate phase variation
Christopher J. R. Turkington, Andrew Morozov, Martha R. J. Clokie, Christopher D. Bayliss   +3 more
doaj   +1 more source

Experimental Evolution of Campylobacter jejuni Leads to Loss of Motility, rpoN (σ54) Deletion and Genome Reduction

Frontiers in Microbiology, 2020
Evolution experiments in the laboratory have focused heavily on model organisms, often to the exclusion of clinically relevant pathogens. The foodborne bacterial pathogen Campylobacter jejuni belongs to a genus whose genomes are small compared to those ...
Azam A. Sher, Azam A. Sher, Azam A. Sher, John P. Jerome, John P. Jerome, John P. Jerome, Julia A. Bell, Julia A. Bell, Julian Yu, Julian Yu, Julian Yu, Hahyung Y. Kim, Hahyung Y. Kim, Jeffrey E. Barrick, Jeffrey E. Barrick, Linda S. Mansfield, Linda S. Mansfield, Linda S. Mansfield, Linda S. Mansfield   +18 more
doaj   +1 more source

Effects of Random Circuit Fabrication Errors on the Mean and Standard Deviation of Small Signal Gain and Phase of a Traveling Wave Tube

IEEE Journal of the Electron Devices Society, 2013
Random fabrication errors may have detrimental effects on the performance of traveling wave tubes (TWTs) of all types, especially in the sub-millimeter wavelength regime and beyond.
Ian M. Rittersdorf, Thomas M. Antonsen, David Chernin, Y. Y. Lau   +3 more
doaj   +1 more source