Results 1 to 10 of about 1,113,115 (292)

Mapping phenotypic heterogeneity in melanoma onto the epithelial-hybrid-mesenchymal axis

Frontiers in Oncology, 2022
Epithelial to mesenchymal transition (EMT) is a well-studied hallmark of epithelial-like cancers that is characterized by loss of epithelial markers and gain of mesenchymal markers.
Maalavika Pillai, Maalavika Pillai, Gouri Rajaram, Pradipti Thakur, Nilay Agarwal, Nilay Agarwal, Srinath Muralidharan, Ankita Ray, Dev Barbhaya, Jason A. Somarelli, Mohit Kumar Jolly   +10 more
doaj   +3 more sources

Phenotypic heterogeneity in the bacterial oxidative stress response is driven by cell-cell interactions

Cell Reports, 2023
Summary: Genetically identical bacterial cells commonly display different phenotypes. This phenotypic heterogeneity is well known for stress responses, where it is often explained as bet hedging against unpredictable environmental threats.
Divya Choudhary, Valentine Lagage, Kevin R. Foster, Stephan Uphoff   +3 more
doaj   +3 more sources

In situ visualization of Clostridioides difficile phenotypic heterogeneity and single-cell morphology during gut infection [PDF]

Nature Communications
Phenotypic heterogeneity refers to the ability of clonal populations of the same species to display distinct phenotypes despite experiencing the same environment.
Nicholas V. DiBenedetto, M. Lauren Donnelly-Morell, Carol A. Kumamoto, Aimee Shen   +3 more
doaj   +2 more sources

Phenotypic heterogeneity of capsule production across opportunistic pathogens [PDF]

mBio
Phenotypic heterogeneity allows bacteria to adapt fast to changing environments. Extracellular capsules are well-known virulence factors, but also increase the cell adaptability and prevalence under hostile conditions.
Amandine Nucci, Julie Le Bris, Sara Diaz-Diaz, Lilibeth Torres-Elizalde, Eduardo P. C. Rocha, Olaya Rendueles   +5 more
doaj   +2 more sources

Negative frequency‐dependent interactions can underlie phenotypic heterogeneity in a clonal microbial population

Molecular Systems Biology, 2016
Genetically identical cells in microbial populations often exhibit a remarkable degree of phenotypic heterogeneity even in homogenous environments.
David Healey, Kevin Axelrod, Jeff Gore
doaj   +2 more sources

Genetics and phenotypic heterogeneity of Galloway–Mowat syndrome [PDF]

Cell Communication and Signaling
Galloway–Mowat syndrome (GAMOS) is a rare autosomal recessive genetic disorder that is underrecognized. The phenotype is heterogeneous, but it is now widely accepted that early-onset nephrotic syndrome (SRNS) and microcephaly with brain malformation are ...
Limin Huang, Yanfei Wang, Yingying Zhang, Haidong Fu, Jianhua Mao   +4 more
doaj   +2 more sources

Phenotypic heterogeneity drives differential disease outcome in a mouse model of triple negative breast cancer

Frontiers in Oncology, 2023
The triple negative breast cancer (TNBC) subtype is one of the most aggressive forms of breast cancer that has poor clinical outcome and is an unmet clinical challenge.
Archana P. Thankamony, Archana P. Thankamony, Sonny Ramkomuth, Shikha T. Ramesh, Shikha T. Ramesh, Reshma Murali, Priyanka Chakraborty, Nitheesh Karthikeyan, Binitha Anu Varghese, Vishnu Sunil Jaikumar, Mohit Kumar Jolly, Alexander Swarbrick, Alexander Swarbrick, Radhika Nair, Radhika Nair   +14 more
doaj   +1 more source

Population Dynamics of Epithelial-Mesenchymal Heterogeneity in Cancer Cells

Biomolecules, 2022
Phenotypic heterogeneity is a hallmark of aggressive cancer behaviour and a clinical challenge. Despite much characterisation of this heterogeneity at a multi-omics level in many cancers, we have a limited understanding of how this heterogeneity emerges ...
Paras Jain, Sugandha Bhatia, Erik W. Thompson, Mohit Kumar Jolly   +3 more
doaj   +1 more source

Phenotypic heterogeneity in modeling cancer evolution. [PDF]

PLoS ONE, 2017
The unwelcome evolution of malignancy during cancer progression emerges through a selection process in a complex heterogeneous population structure. In the present work, we investigate evolutionary dynamics in a phenotypically heterogeneous population of
Ali Mahdipour-Shirayeh, Kamran Kaveh, Mohammad Kohandel, Sivabal Sivaloganathan   +3 more
doaj   +1 more source

Topological signatures in regulatory network enable phenotypic heterogeneity in small cell lung cancer

eLife, 2021
Phenotypic (non-genetic) heterogeneity has significant implications for the development and evolution of organs, organisms, and populations. Recent observations in multiple cancers have unraveled the role of phenotypic heterogeneity in driving metastasis
Lakshya Chauhan, Uday Ram, Kishore Hari, Mohit Kumar Jolly   +3 more
doaj   +1 more source