Results 1 to 10 of about 3,636 (65)
Molecular Systems Biology, 2016 Genetically identical cells in microbial populations often exhibit a remarkable degree of phenotypic heterogeneity even in homogenous environments.
David Healey, Kevin Axelrod, Jeff Gore
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Single-Cell Technologies to Study Phenotypic Heterogeneity and Bacterial Persisters
Microorganisms, 2021 Antibiotic persistence is a phenomenon in which rare cells of a clonal bacterial population can survive antibiotic doses that kill their kin, even though the entire population is genetically susceptible.
Patricia J. Hare +4 more
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Frontiers in Microbiology, 2019 Phenotypic heterogeneity within microbial populations arises even when the cells are exposed to putatively constant and homogeneous conditions. The outcome of this phenomenon can affect the whole function of the population, resulting in, for example, new
Federica Calabrese +10 more
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Frontiers in Oncology, 2023 The triple negative breast cancer (TNBC) subtype is one of the most aggressive forms of breast cancer that has poor clinical outcome and is an unmet clinical challenge.
Archana P. Thankamony +14 more
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Population Dynamics of Epithelial-Mesenchymal Heterogeneity in Cancer Cells
Biomolecules, 2022 Phenotypic heterogeneity is a hallmark of aggressive cancer behaviour and a clinical challenge. Despite much characterisation of this heterogeneity at a multi-omics level in many cancers, we have a limited understanding of how this heterogeneity emerges ...
Paras Jain +3 more
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Phenotypic heterogeneity in modeling cancer evolution. [PDF]
PLoS ONE, 2017 The unwelcome evolution of malignancy during cancer progression emerges through a selection process in a complex heterogeneous population structure. In the present work, we investigate evolutionary dynamics in a phenotypically heterogeneous population of
Ali Mahdipour-Shirayeh +3 more
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eLife, 2021 Phenotypic (non-genetic) heterogeneity has significant implications for the development and evolution of organs, organisms, and populations. Recent observations in multiple cancers have unraveled the role of phenotypic heterogeneity in driving metastasis
Lakshya Chauhan +3 more
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Cell Reports, 2023 Summary: Genetically identical bacterial cells commonly display different phenotypes. This phenotypic heterogeneity is well known for stress responses, where it is often explained as bet hedging against unpredictable environmental threats.
Divya Choudhary +3 more
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Mapping phenotypic heterogeneity in melanoma onto the epithelial-hybrid-mesenchymal axis
Frontiers in Oncology, 2022 Epithelial to mesenchymal transition (EMT) is a well-studied hallmark of epithelial-like cancers that is characterized by loss of epithelial markers and gain of mesenchymal markers.
Maalavika Pillai +10 more
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Phenotypic heterogeneity of sitosterolemia
Journal of Lipid Research, 2004 Sitosterolemia is a rare autosomal recessive disorder of lipoprotein metabolism characterized by xanthomas and increased plasma concentrations of plant sterols, such as sitosterol.
Jian Wang +4 more
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