Results 11 to 20 of about 172,226 (152)

Phenotypic heterogeneity of monogenic frontotemporal dementia [PDF]

Frontiers in Aging Neuroscience, 2015
Frontotemporal dementia (FTD) is a genetically and pathologically heterogeneous disorder characterized by personality changes, language impairment and deficits of executive functions associated with frontal and temporal lobe degeneration.
Alberto eBenussi, Alessandro ePadovani, Barbara eBorroni   +2 more
doaj   +5 more sources

Phenotypic heterogeneity promotes adaptive evolution.

PLoS Biology, 2017
Genetically identical cells frequently display substantial heterogeneity in gene expression, cellular morphology and physiology. It has been suggested that by rapidly generating a subpopulation with novel phenotypic traits, phenotypic heterogeneity (or ...
Zoltán Bódi, Zoltán Farkas, Dmitry Nevozhay, Dorottya Kalapis, Viktória Lázár, Bálint Csörgő, Ákos Nyerges, Béla Szamecz, Gergely Fekete, Balázs Papp, Hugo Araújo, José L Oliveira, Gabriela Moura, Manuel A S Santos, Tamás Székely, Gábor Balázsi, Csaba Pál   +16 more
doaj   +5 more sources

Phenotypic heterogeneity of MELAS

Molecular Genetics and Metabolism Reports, 2017
Josef Finsterer, Sinda Zarrouk-Mahjoub
doaj   +3 more sources

In situ visualization of Clostridioides difficile phenotypic heterogeneity and single-cell morphology during gut infection [PDF]

Nature Communications
Phenotypic heterogeneity refers to the ability of clonal populations of the same species to display distinct phenotypes despite experiencing the same environment.
Nicholas V. DiBenedetto, M. Lauren Donnelly-Morell, Carol A. Kumamoto, Aimee Shen   +3 more
doaj   +2 more sources

Phenotypic heterogeneity of capsule production across opportunistic pathogens [PDF]

mBio
Phenotypic heterogeneity allows bacteria to adapt fast to changing environments. Extracellular capsules are well-known virulence factors, but also increase the cell adaptability and prevalence under hostile conditions.
Amandine Nucci, Julie Le Bris, Sara Diaz-Diaz, Lilibeth Torres-Elizalde, Eduardo P. C. Rocha, Olaya Rendueles   +5 more
doaj   +2 more sources

The evolutionary advantage of heritable phenotypic heterogeneity [PDF]

Scientific Reports, 2017
Phenotypic plasticity is an evolutionary driving force in diverse biological processes, including the adaptive immune system, the development of neoplasms, and the persistence of pathogens despite drug pressure.
Oana Carja, Joshua B. Plotkin
doaj   +3 more sources

Genetics and phenotypic heterogeneity of Galloway–Mowat syndrome [PDF]

Cell Communication and Signaling
Galloway–Mowat syndrome (GAMOS) is a rare autosomal recessive genetic disorder that is underrecognized. The phenotype is heterogeneous, but it is now widely accepted that early-onset nephrotic syndrome (SRNS) and microcephaly with brain malformation are ...
Limin Huang, Yanfei Wang, Yingying Zhang, Haidong Fu, Jianhua Mao   +4 more
doaj   +2 more sources

Phenotypic heterogeneity and plasticity in colorectal cancer metastasis [PDF]

Cell Genomics
Summary: Phenotypic heterogeneity and plasticity in colorectal cancer (CRC) has a crucial role in tumor progression, metastasis, and therapy resistance.
Samuel Ogden, Nasrine Metic, Ozen Leylek, Elise A. Smith, Alison M. Berner, Ann-Marie Baker, Imran Uddin, Marta Buzzetti, Marco Gerlinger, Trevor Graham, Hemant M. Kocher, Mirjana Efremova   +11 more
doaj   +2 more sources

Editorial: Phenotypic and functional heterogeneity of neutrophils

Frontiers in Immunology, 2023
non ...
Nicola Tamassia, Sebastien Jaillon, Sebastien Jaillon   +2 more
doaj   +4 more sources

Bacteriophage-driven microbial phenotypic heterogeneity: ecological and biogeochemical importance [PDF]

npj Biofilms and Microbiomes
Bacteriophages (phages) reprogram host metabolism and generate phenotypic heterogeneity, yet the mechanisms and ecological implications remain poorly understood representing a major knowledge gap in microbial ecology.
Xiaolong Liang, Shuo Yang, Mark Radosevich, Yongfeng Wang, Ning Duan, Yongfeng Jia   +5 more
doaj   +2 more sources