Results 31 to 40 of about 172,226 (152)

Cancer associated fibroblasts: phenotypic and functional heterogeneity

Frontiers in Bioscience-Landmark, 2020
Cancer associated fibroblasts (CAFs) are the most abundant stromal cell-type in solid tumor-microenvironment (TME) and have emerged as key player in tumor progression.
Ankit Kumar Patel, Sandeep Singh
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Modeling phenotypic heterogeneity towards evolutionarily inspired osteosarcoma therapy

Scientific Reports, 2023
Osteosarcoma is the most common bone sarcoma in children and young adults. While universally delivered, chemotherapy only benefits roughly half of patients with localized disease.
Darcy L. Welch, Brooke L. Fridley, Ling Cen, Jamie K. Teer, Sean J. Yoder, Fredrik Pettersson, Liping Xu, Chia-Ho Cheng, Yonghong Zhang, Mark G. Alexandrow, Shengyan Xiang, Mark Robertson-Tessi, Joel S. Brown, Jonathan Metts, Andrew S. Brohl, Damon R. Reed   +15 more
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Obstetric Phenotypes in the Heterogeneity of Schizophrenia

Journal of Nervous & Mental Disease, 2018
Abstract Schizophrenia is a complex mental disorder with genetic and environmental components. Obstetric complications (OCs) are one of the most common environmental risk factors described. However, despite being different in timing and outcome, OCs are usually described as a homogeneous entity.
Mezquida, Gisela, Fernandez-Egea, Emilio, Treen, Devi, Mané, Anna, Bergé, Daniel, Savulich, George, Garcia-Alvarez, Leticia, García-Portilla, Paz, Bobes, Julio, Bernardo, Miguel, Garcia-Rizo, Clemente   +10 more
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Correction: Phenotypic heterogeneity promotes adaptive evolution.

PLoS Biology, 2017
[This corrects the article DOI: 10.1371/journal.pbio.2000644.].
Zoltán Bódi, Zoltán Farkas, Dmitry Nevozhay, Dorottya Kalapis, Viktória Lázár, Bálint Csörgő, Ákos Nyerges, Béla Szamecz, Gergely Fekete, Balázs Papp, Hugo Araújo, José L Oliveira, Gabriela Moura, Manuel A S Santos, Tamás Székely, Gábor Balázsi, Csaba Pál   +16 more
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Phenotypic Heterogeneity in Pathogens

Annual Review of Genetics
Pathogen diversity within an infected organism has traditionally been explored through the lens of genetic heterogeneity. Hallmark studies have characterized how genetic diversity within pathogen subpopulations contributes to treatment escape and infectious disease progression.
Jessica, Sherry, E Hesper, Rego
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Phenotypic heterogeneity in the stargazin allelic series [PDF]

Mammalian Genome, 2003
The stargazer mutant mouse is characterized by its ataxic gait, head tossing, and absence seizures. The mutation was identified in the gamma 2 subunit gene of the high voltage-dependent calcium channel, Cacng2. Subsequently, two allelic variants of stargazer have arisen, waggler and stargazer 3J. In this study, we have compared these new alleles to the
Letts, V A, Kang, M G, Mahaffey, C L, Beyer, B, Tenbrink, H, Campbell, K P, Frankel, W N   +6 more
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Phenotypic heterogeneity in Streptomyces colonies

Current Opinion in Microbiology
Streptomyces are a large genus of multicellular bacteria best known for their prolific production of bioactive natural products. In addition, they play key roles in the mineralisation of insoluble resources, such as chitin and cellulose. Because of their multicellular mode of growth, colonies of interconnected hyphae extend over a large area that may ...
Hiskisson, P.A., Barona-Gómez, F., Rozen, D.E.   +2 more
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High-throughput sequencing analysis reveals genomic similarity in phenotypic heterogeneous Photorhabdus luminescens cell populations

Annals of Microbiology, 2022
Purpose Phenotypic heterogeneity occurs in many bacterial populations: single cells of the same species display different phenotypes, despite being genetically identical.
Nazzareno Dominelli, Heidi Yoko Jäger, Angela Langer, Andreas Brachmann, Ralf Heermann   +4 more
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Distinct disease mutations in DNMT3A result in a spectrum of behavioral, epigenetic, and transcriptional deficits

Cell Reports, 2023
Summary: Phenotypic heterogeneity in monogenic neurodevelopmental disorders can arise from differential severity of variants underlying disease, but how distinct alleles drive variable disease presentation is not well understood.
Diana C. Beard, Xiyun Zhang, Dennis Y. Wu, Jenna R. Martin, Alyssa Erickson, Jane Valeriane Boua, Nicole Hamagami, Raylynn G. Swift, Katherine B. McCullough, Xia Ge, Austin Bell-Hensley, Hongjun Zheng, Cory W. Palmer, Nicole A. Fuhler, Austin B. Lawrence, Cheryl A. Hill, Thomas Papouin, Kevin K. Noguchi, Audrey McAlinden, Joel R. Garbow, Joseph D. Dougherty, Susan E. Maloney, Harrison W. Gabel   +22 more
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Phenotypic Heterogeneity in Mycobacterium tuberculosis

Microbiology Spectrum, 2016
ABSTRACT The interaction between the host and the pathogen is extremely complex and is affected by anatomical, physiological, and immunological diversity in the microenvironments, leading to phenotypic diversity of the pathogen. Phenotypic heterogeneity, defined as nongenetic variation observed in individual members of a clonal ...
Dhar, Neeraj, Mckinney, John, Manina, Giulia   +2 more
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