Results 31 to 40 of about 1,113,115 (292)
Phenotypic heterogeneity of ZMPSTE24 deficiency [PDF]
American Journal of Medical Genetics Part A, 2018 A 4‐year‐old girl was referred to the Undiagnosed Diseases Network with a history of short stature, thin and translucent skin, macrocephaly, small hands, and camptodactyly. She had been diagnosed with possible Hallerman–Streiff syndrome. Her evaluation showed that she was mosaic for uniparental isodisomy of chromosome 1, which harbored a pathogenic c ...
Thomas A. Cassini +7 more
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Privatization of Biofilm Matrix in Structurally Heterogeneous Biofilms
mSystems, 2020 The self-produced biofilm provides beneficial protection for the enclosed cells, but the costly production of matrix components makes producer cells susceptible to cheating by nonproducing individuals.
Simon B. Otto +7 more
doaj +1 more source
Immunodeficiency in Vici syndrome: A heterogeneous phenotype [PDF]
American Journal of Medical Genetics Part A, 2011 AbstractVici syndrome is a rare congenital multisystem disorder characterized by agenesis of the corpus callosum, hypotonia, developmental delay, hypopigmentation, cataract, cardiomyopathy, and immunological abnormalities. Recurrent infections, mainly affecting the respiratory tract, have been reported in the majority of cases, representing an ...
FINOCCHI, ANDREA +8 more
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Modeling the emergence of phenotypic heterogeneity in vascularized tumors [PDF]
, 2021 We present a mathematical study of the emergence of phenotypic heterogeneity in vascularized tumors. Our study is based on formal asymptotic analysis and numerical simulations of a system of nonlocal parabolic equations that describes the phenotypic ...
Villa C., Lorenzi T., Chaplain M. A.
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Phenotypic heterogeneity in mycobacterial stringent response [PDF]
BMC Systems Biology, 2011 Abstract Background A common survival strategy of microorganisms subjected to stress involves the generation of phenotypic heterogeneity in the isogenic microbial population enabling a subset of the population to survive under stress. In a recent study, a mycobacterial population of M.
Sayantari Ghosh +5 more
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Phenotypic heterogeneity in fungi: importance and methodology [PDF]
, 2016 Phenotypic heterogeneity describes the variation that exists between individual cells, spores or other biological entities within genetically-uniform populations of fungi or other organisms.
Hewitt, Sarah K. +3 more
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One Health & Risk Management, 2021 Introduction. In recent years, due to wide applications of nanotechnologies in various fields, the safety of nanomaterials has become a pressing issue. Fullerene C60 is not an exception.
Olga POSTOLACHI +2 more
doaj +3 more sources
Cancer associated fibroblasts: phenotypic and functional heterogeneity
Frontiers in Bioscience-Landmark, 2020 Cancer associated fibroblasts (CAFs) are the most abundant stromal cell-type in solid tumor-microenvironment (TME) and have emerged as key player in tumor progression.
Ankit Kumar Patel, Sandeep Singh
doaj +1 more source
Modeling phenotypic heterogeneity towards evolutionarily inspired osteosarcoma therapy
Scientific Reports, 2023 Osteosarcoma is the most common bone sarcoma in children and young adults. While universally delivered, chemotherapy only benefits roughly half of patients with localized disease.
Darcy L. Welch +15 more
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Cellular Environment and Phenotypic Heterogeneity: How Data-Driven Modeling Finds the Smoking Gun
, 2022 The cellular environment modifies cellular phenotypes, in particular, the stress response phenotype, which easily exhibits high phenotypic heterogeneity due to the common characteristics of its regulatory networks. The aim of this work is to quantify and
Quentin Thommen +5 more
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