Results 41 to 50 of about 1,113,115 (292)

Obstetric Phenotypes in the Heterogeneity of Schizophrenia

Journal of Nervous & Mental Disease, 2018
Abstract Schizophrenia is a complex mental disorder with genetic and environmental components. Obstetric complications (OCs) are one of the most common environmental risk factors described. However, despite being different in timing and outcome, OCs are usually described as a homogeneous entity.
Mezquida, Gisela, Fernandez-Egea, Emilio, Treen, Devi, Mané, Anna, Bergé, Daniel, Savulich, George, Garcia-Alvarez, Leticia, García-Portilla, Paz, Bobes, Julio, Bernardo, Miguel, Garcia-Rizo, Clemente   +10 more
openaire   +3 more sources

Correction: Phenotypic heterogeneity promotes adaptive evolution.

PLoS Biology, 2017
[This corrects the article DOI: 10.1371/journal.pbio.2000644.].
Zoltán Bódi, Zoltán Farkas, Dmitry Nevozhay, Dorottya Kalapis, Viktória Lázár, Bálint Csörgő, Ákos Nyerges, Béla Szamecz, Gergely Fekete, Balázs Papp, Hugo Araújo, José L Oliveira, Gabriela Moura, Manuel A S Santos, Tamás Székely, Gábor Balázsi, Csaba Pál   +16 more
doaj   +1 more source

Phenotypic heterogeneity in the stargazin allelic series [PDF]

Mammalian Genome, 2003
The stargazer mutant mouse is characterized by its ataxic gait, head tossing, and absence seizures. The mutation was identified in the gamma 2 subunit gene of the high voltage-dependent calcium channel, Cacng2. Subsequently, two allelic variants of stargazer have arisen, waggler and stargazer 3J. In this study, we have compared these new alleles to the
Letts, V A, Kang, M G, Mahaffey, C L, Beyer, B, Tenbrink, H, Campbell, K P, Frankel, W N   +6 more
openaire   +3 more sources

Phenotypic Heterogeneity in Pathogens

Annual Review of Genetics
Pathogen diversity within an infected organism has traditionally been explored through the lens of genetic heterogeneity. Hallmark studies have characterized how genetic diversity within pathogen subpopulations contributes to treatment escape and infectious disease progression.
Jessica, Sherry, E Hesper, Rego
openaire   +2 more sources

Genetic correlates of phenotypic heterogeneity in autism [PDF]

Nature Genetics, 2020
Abstract The substantial phenotypic heterogeneity in autism limits our understanding of its genetic aetiology. To address this gap, we investigated genetic differences between autistic individuals (N max = 12,893) based on core (i.e., social communication difficulties, and ...
Varun Warrier, Xinhe Zhang, Patrick Reed, Alexandra Havdahl, Tyler M. Moore, Freddy Cliquet, Claire S. Leblond, Thomas Rolland, Anders Rosengren, Antonia San Jose Caceres, Hannah Hayward, Daisy Crawley, Jessica Faulkner, Jessica Sabet, Claire Ellis, Bethany Oakley, Eva Loth, Tony Charman, Declan Murphy, Rosemary Holt, Jack Waldman, Jessica Upadhyay, Nicola Gunby, Meng-Chuan Lai, Gwilym Renouf, Amber Ruigrok, Emily Taylor, Hisham Ziauddeen, Julia Deakin, Sara Ambrosino di Bruttopilo, Sarai van Dijk, Yvonne Rijks, Tabitha Koops, Miriam Douma, Alyssia Spaan, Iris Selten, Maarten Steffers, Anna Ver Loren van Themaat, Nico Bast, Sarah Baumeister, Larry O’Dwyer, Carsten Bours, Annika Rausch, Daniel von Rhein, Ineke Cornelissen, Yvette de Bruin, Maartje Graauwmans, Elzbieta Kostrzewa, Elodie Cauvet, Kristiina Tammimies, Rouslan Sitnikow, Guillaume Dumas, Yang-Min Kim, Thomas Bourgeron, David M. Hougaard, Jonas Bybjerg-Grauholm, Thomas Werge, Preben Bo Mortensen, Ole Mors, Merete Nordentoft, Dwaipayan Adhya, Armandina Alamanza, Carrie Allison, Isabelle Garvey, Tracey Parsons, Paula Smith, Alex Tsompanidis, Graham J. Burton, Alexander E. P. Heazell, Lidia V. Gabis, Tal Biron-Shental, Madeline A. Lancaster, Deepak P. Srivastava, Jonathan Mill, David H. Rowitch, Matthew E. Hurles, Daniel H. Geschwind, Anders D. Børglum, Elise B. Robinson, Jakob Grove, Hilary C. Martin, Thomas Bourgeron, Simon Baron-Cohen   +82 more
openaire   +7 more sources

Heterogeneity of phenotypic proportions.

, 2018
Heterogeneity of phenotypic proportions.
Getachew Tadesse (3281049), Tesfaye S. Tessema (4846672), Getenet Beyene (3432986), Abraham Aseffa (108981)   +3 more
core   +1 more source

Phenotypic changes in different spinach varieties grown and selected under organic conditions [PDF]

, 2011
Organic and low-input agriculture needs flexible varieties that can buffer environmental stress and adapt to the needs of farmers. We implemented an experiment to investigate the evolutionary capacities of a sample of spinach (Spinacia oleracea L ...
Goldringer, I., Chable, V., Goldringer, Isabelle, Edith T. Lammerts van Bueren, Lammerts Van Bueren, E., Schermann, Nicolas, Nicolas Schermann, Serpolay, Estelle, Schermann, N., Isabelle Goldringer, Dawson, J.C., Chable, Veronique, Julie Dawson, Estelle Serpolay, Véronique Chable, Serpolay, E., Lammerts van Bueren, Edith, Dawson, Julie   +17 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

High-throughput sequencing analysis reveals genomic similarity in phenotypic heterogeneous Photorhabdus luminescens cell populations

Annals of Microbiology, 2022
Purpose Phenotypic heterogeneity occurs in many bacterial populations: single cells of the same species display different phenotypes, despite being genetically identical.
Nazzareno Dominelli, Heidi Yoko Jäger, Angela Langer, Andreas Brachmann, Ralf Heermann   +4 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source