Results 61 to 70 of about 1,113,115 (292)

Phenotypic heterogeneity in Pseudomonas syringae [PDF]

, 2019
The notion of isogenic bacterial populations displaying phenotypic differences is widely accepted today. A particular case of phenotypic heterogeneity is bistability.
Ruiz-Albert, Francisco Javier, Aussel, Laurant, Rufián Plaza, José Sebastián, Aussel, Laurent, Rufián, José S., López-Pagán, Nieves, Sánchez-Romero, María Antonia, Govantes, Fernando, Ruiz-Albert, Javier   +8 more
core  

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Multiple Regulatory Mechanisms Control the Production of CmrRST, an Atypical Signal Transduction System in Clostridioides difficile

mBio, 2022
Clostridioides difficile, an intestinal pathogen and leading cause of nosocomial infection, exhibits extensive phenotypic heterogeneity through phase variation.
Elizabeth M. Garrett, Anchal Mehra, Ognjen Sekulovic, Rita Tamayo   +3 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Bacterial phenotypic heterogeneity in DNA repair and mutagenesis [PDF]

, 2020
Genetically identical cells frequently exhibit striking heterogeneity in various phenotypic traits such as their morphology, growth rate, or gene expression.
Uphoff, Stephan, Vincent, Maxence, Vincent, Maxence S   +2 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Evolution of phenotypic plasticity leads to tumor heterogeneity with implications for therapy.

PLoS Computational Biology
Cancer is a significant global health issue, with treatment challenges arising from intratumor heterogeneity. This heterogeneity stems mainly from somatic evolution, causing genetic diversity within the tumor, and phenotypic plasticity of tumor cells ...
Simon Syga, Harish P Jain, Marcus Krellner, Haralampos Hatzikirou, Andreas Deutsch   +4 more
doaj   +1 more source

Heterozygous variants in PLCG1 affect hearing, vision, cardiac, and immune function

eLife
Phospholipase C isozymes (PLCs) hydrolyze phosphatidylinositol 4,5-bisphosphate (PIP2) into inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG), important signaling molecules involved in many cellular processes including Ca2+ release from the ...
Mengqi Ma, Yiming Zheng, Mingxi Deng, Shenzhao Lu, Xueyang Pan, Xi Luo, Michelle Etoundi, David Li-Kroeger, Kim C Worley, Lindsay C Burrage, Lauren S Blieden, Aimee Allworth, Wei-Liang Chen, Giuseppe Merla, Barbara Mandriani, Catherine E Otten, Pierre Blanc, Jill A Rosenfeld, Debdeep Dutta, Shinya Yamamoto, Michael F Wangler, Ian A Glass, Jingheng Chen, Elizabeth Blue, Paolo Prontera, Jeremie Rosain, Sandrine Marlin, Seema R Lalani, Hugo J Bellen, Undiagnosed Diseases Network   +29 more
doaj   +1 more source

Phenotypic heterogeneity during plant colonization [PDF]

, 2019
Isogenic bacterial populations can display phenotypic differences. Cell-to-cell phenotypic differences can be a consequence of noisy gene expression, or a programmed event under genetic or epigenetic control.
Schikora, Adam, Ruiz-Albert, Francisco Javier, Aussel, Laurant, Beuzón, Carmen R., Rufián Plaza, José Sebastián, Aussel, Laurent, Beuzón-López, Carmen del Rosario, Rufián, José S., López-Pagán, Nieves, Sánchez-Romero, María Antonia, Govantes, Fernando   +10 more
core  

Phenotypic Heterogeneity of Streptococcus mutans in Dentin

, 2008
Information concerning phenotypic heterogeneity of Streptococcus mutans in carious dentin is sparse. Matrix-assisted laser-desorption/ionizationtime- of-flight mass-spectrometry (MALDI-TOFMS) facilitates the phenotypic differentiation of bacteria to
Breitung, K., Rupf, S., Kneist, S., Eschrich, K., Remmerbach, Torsten, Schellenberger, W., Hannig, M.   +6 more
core   +1 more source