Results 81 to 90 of about 1,113,115 (292)

Computational models for prediction of yeast strain potential for winemaking from phenotypic profiles [PDF]

, 2013
Saccharomyces cerevisiae strains from diverse natural habitats harbour a vast amount of phenotypic diversity, driven by interactions between yeast and the respective environment. In grape juice fermentations, strains are exposed to a wide array of biotic
Mendes, Mendes, Dequin, Sylvie, Schuller, Dorit, João Drumonde-Neves, Ricardo Franco-Duarte, Inês Mendes, João Drumonde-Neves (433942), Mendes Inês, Fonseca Elza, Elza Fonseca (433941), Schuller, Dorit Elisabeth, Fonseca, Elza, Zupan Blaz, Lan Umek, Schuller Dorit, Sylvie Dequin (205208), Dorit Schuller (181699), Franco-Duarte, Ricardo, Sylvie Dequin, Dequin Sylvie, Dorit Schuller, Zupan, Blaz, Umek, Lan, Drumonde-Neves João, Mendes, Inês Isabel Moreira Moutinho Vieira, Lan Umek (433940), Drumonde-Neves, Joao, Umek Lan, Inês Mendes (433938), Elza Fonseca, Blaz Zupan (10031), Mendes, Ines, Franco-Duarte Ricardo, Ricardo Franco-Duarte (433939), Blaz Zupan   +34 more
core   +2 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Quantitation and Comparison of Phenotypic Heterogeneity Among Single Cells of Monoclonal Microbial Populations

Frontiers in Microbiology, 2019
Phenotypic heterogeneity within microbial populations arises even when the cells are exposed to putatively constant and homogeneous conditions. The outcome of this phenomenon can affect the whole function of the population, resulting in, for example, new
Federica Calabrese, Iryna Voloshynovska, Florin Musat, Martin Thullner, Michael Schlömann, Hans H. Richnow, Johannes Lambrecht, Susann Müller, Lukas Y. Wick, Niculina Musat, Hryhoriy Stryhanyuk   +10 more
doaj   +1 more source

Genetic analysis of environmental variation [PDF]

, 2010
Environmental variation (V-E) in a quantitative trait - variation in phenotype that cannot be explained by genetic variation or identifiable genetic differences - can be regarded as being under some degree of genetic control. Such variation may be either
HAN A. MULDER, Hill, William G., WILLIAM G. HILL, Mulder, H.A., Mulder, Han A., Hill, W.G.   +5 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Dynamic phenotypic heterogeneity and the evolution of multiple RNA subtypes in Hepatocellular Carcinoma: the PLANET study [PDF]

, 2021
Intra-tumor heterogeneity (ITH) is a key challenge in cancer treatment, but previous studies have focused mainly on the genomic alterations without exploring phenotypic (transcriptomic and immune) heterogeneity.
Ong, DB-L, Ma, S, Pang, YH, Chan, CY, Chanwat, R, de Villa, VH, Madhavan, K, Chew, SC, Cheow, PC, Dela Cruz, RD, Foo, RS-Y, Thammasiri, J, Lee, SY, Dan, YY, Lai, H, Yoong, BK, Zhai, W, Yang, H, Chang, MM, Loh, TJ, Toh, HC, Lu, B, Bonney, G, Chua, KP, Kam, JH, Wu, L, Zeng, Z, Lim, TK-H, Goh, BKP, Alvarez, JJS, Wan, WK, Skanderup, AJ, Chen, PJ, Tam, WL, Lim, JQ, Jianbin, C, Chew, V, Leow, WQ, Kow, AW-C, Iyer, SG, Chow, PK-H, Kaya, NA, Chung, AY-F   +42 more
core   +1 more source

Increased prevalence of hybrid epithelial/mesenchymal state and enhanced phenotypic heterogeneity in basal breast cancer

iScience
Summary: Intra-tumoral phenotypic heterogeneity promotes tumor relapse and therapeutic resistance and remains an unsolved clinical challenge. Decoding the interconnections among different biological axes of plasticity is crucial to understand the ...
Sarthak Sahoo, Soundharya Ramu, Madhumathy G. Nair, Maalavika Pillai, Beatriz P. San Juan, Heloisa Zaccaron Milioli, Susmita Mandal, Chandrakala M. Naidu, Apoorva D. Mavatkar, Harini Subramaniam, Arpita G. Neogi, Christine L. Chaffer, Jyothi S. Prabhu, Jason A. Somarelli, Mohit Kumar Jolly   +14 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Phenotypic heterogeneity in metabolic traits among single cells of a rare bacterial species in its natural environment quantified with a combination of flow cell sorting and NanoSIMS

Frontiers in Microbiology, 2015
Populations of genetically identical microorganisms residing in the same environment can display marked variability in their phenotypic traits; this phenomenon is termed phenotypic heterogeneity. The relevance of such heterogeneity in natural habitats is
Matthias eZimmermann, Matthias eZimmermann, Stéphane eEscrig, Thomas eHübschmann, Mathias eKirf, Andreas eBrand, Andreas eBrand, R Fredrik Inglis, R Fredrik Inglis, Niculina eMusat, Susann eMüller, Anders eMeibom, Anders eMeibom, Martin eAckermann, Martin eAckermann, Frank eSchreiber, Frank eSchreiber   +16 more
doaj   +1 more source