Results 101 to 110 of about 1,113,115 (292)

Phenotypic heterogeneity and plasticity in colorectal cancer metastasis

Cell Genomics
Summary: Phenotypic heterogeneity and plasticity in colorectal cancer (CRC) has a crucial role in tumor progression, metastasis, and therapy resistance.
Samuel Ogden, Nasrine Metic, Ozen Leylek, Elise A. Smith, Alison M. Berner, Ann-Marie Baker, Imran Uddin, Marta Buzzetti, Marco Gerlinger, Trevor Graham, Hemant M. Kocher, Mirjana Efremova   +11 more
doaj   +1 more source

Phenotypic intrafamilial heterogeneity in cystic fibrosis.

, 1993
[No abstract available] Letter Comment in Phenotypic heterogeneity in CF sibs compound heterozygous for the G85E and 621 + 1G-->T mutations.
P. Ronchetto, DEVOTO, MARCELLA, Devoto M, G. Romeo, Mastella G, G. Borgo, Borgo G, Romeo G., G. Cabrini, G. Mastella, Ronchetto P, CABRINI, GIULIO   +11 more
core   +1 more source

Phenotypic heterogeneity is an evolutionarily conserved feature of the endothelium.

, 2007
Mammalian endothelial cells (ECs) display marked phenotypic heterogeneity. Little is known about the evolutionary mechanisms underlying EC heterogeneity. The last common ancestor of hagfish and gnathostomes was also the last common ancestor of all extant
Yano, K;Gale, D;Massberg, S;Cheruvu, PK;Monahan-Earley, R;Morgan, ES;Haig, D;von Andrian, UH;Dvorak, AM;Aird, WC
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Single-growing units phenotypic heterogeneity in Streptococcus thermophilus DSM 20617

, 2011
Microbial cell individuality is a source of phenotypic heterogeneity. This heterogeneity is related to stochastic fluctuations in transcription or translation, despite genetically homogeneous background and constant environment conditions.
S. Arioli, S. Guglielmetti, D. Mora, D. Zambelli   +3 more
core   +2 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Measurement of Heterogeneity in Computational Psychiatry

, 2020
We introduce representational Rényi heterogeneity (RRH), which generalizes existing heterogeneity measurement approaches from ecology (biodiversity measures) and economics (inequality measures).
Nunes, Abraham
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Phenotypic heterogeneity of Pseudomonas syringae van Hall

, 1991
Phenotypic heterogeneity of [i]Pseudomonas syringa[/i]e van ...
Bollet, C., Hunault, G., Gardan, Louis, Hunault, Gilles, Cottin, S.   +4 more
core  

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source