Results 111 to 120 of about 1,113,115 (292)

Enhancers mapping uncovers phenotypic heterogeneity and evolution in patients with luminal breast cancer [PDF]

, 2018
The degree of intrinsic and interpatient phenotypic heterogeneity and its role in tumor evolution is poorly understood. Phenotypic drifts can be transmitted via inheritable transcriptional programs.
Hadjiminas, Dimitri J, Hadjiminas DJ, Győrffy, B, Magnani L, Kate Goddard, Magnani, L, Peter Scacheri, Goddard K, Iros Barozzi, Patten, DK, Scacheri, Peter, Shousha S, Ylenia Perone, Corleone, Giacomo, Shousha, S, Patten DK, Edina Erdős, Pongor, Lőrinc, Pongor, Lőrinc Sándor, Perone, Y, Saiakhova, Alina, Saiakhova A, Patten, D. K., Perone, Ylenia, Coombes RC, Andrea Vingiani, Carlo Palmieri, Raul C. Coombes, Coombes, RC, Slaven, N., Slaven, Neil, Pongor, LS, Giancarlo Pruneri, Sami Shousha, Magnani, Luca, Shousha, Sami, Erdős, Edina, Vingiani, Andrea, Hadjiminas, DJ, Palmieri, C, Schiavon G, Goddard, K, Perone Y, Palmieri C, Slaven N, Alina Saiakhova, Palmieri, Carlo, Perone, Y., Vingiani A, Giacomo Corleone, Corleone, G., Lőrinc Sándor Pongor, Gaia Schiavon, Saiakhova, A, Győrffy, Balázs, Barozzi I, Goddard, Kate, Barozzi, I, Erdős, E, Pruneri, G, Coombes, Raul C, Scacheri P, Dimitri J. Hadjiminas, Vingiani, A, Barry, Peter, Luca Magnani, Slaven, N, Corleone, G, Scacheri, P, Barozzi, Iros, Schiavon, G, Barry, P, Pruneri G, Balázs Győrffy, Patten, Darren K, Barry P, Pruneri, Giancarlo, Corleone G, Neil Slaven, Peter Barry, Schiavon, Gaia, Darren K. Patten   +81 more
core   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Editorial: The heterogeneity in COPD phenotypes

Frontiers in Medicine, 2022
Naoya Tanabe, Chin Kook Rhee, Hye Yun Park, Masaru Suzuki   +3 more
openaire   +3 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Repolarizing heterogeneous leukemia-associated macrophages with more M1 characteristics eliminates their pro-leukemic effects

OncoImmunology, 2018
Macrophages exhibit phenotypic heterogeneity under both physiological and pathological conditions. Applications targeting M2-like tumor-associated macrophages (TAMs) improve outcome in solid tumors.
Xiao Yang, Wenli Feng, Rong Wang, Feifei Yang, Lina Wang, Shayan Chen, Yongxin Ru, Tao Cheng, Guoguang Zheng   +8 more
doaj   +1 more source

4000 Years of Phenotypic Change in an Island Bird: Heterogeneity of Selection Over Three Microevolutionary Timescales

, 2008
Pronounced phenotypic shifts in island populations are typically attributed to natural selection, but reconstructing heterogeneity in long-term selective regimes remains a challenge.
Clegg, Sonya M, Tavecchia, G., Clegg, S.M., Frentiu, F., Owens, I.P.F., Kikkawa, Jiro, Owens, I.P., Owens, Ian P.F., Jiro Kikkawa, Clegg, S., M. Clegg, Sonya, Clegg, Sonya M., Tavecchia, Giacomo, Frentiu, Francesca D, Ian P. F. Owens, D. Frentiu, Francesca, Kikkawa, J., Giacomo Tavecchia, Owens, Ian PF, Frentiu, F.D., Francesca D. Frentiu, Sonya M. Clegg, Frentiu, Francesca D., Owens, Ian P. F.   +23 more
core   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Homogenizing bacterial cell factories: Analysis and engineering of phenotypic heterogeneity

, 2017
In natural habitats, microbes form multispecies communities that commonly face rapidly changing and highly competitive environments. Thus, phenotypic heterogeneity has evolved as an innate and important survival strategy to gain an overall fitness ...
Wiechert, Wolfgang, Jaeger, Karl-Erich, Kohlheyer, D., Grünberger, Alexander, Dietrich Kohlheyer, Drepper, Thomas, Wolfgang Wiechert, Binder, D., Dennis Binder, Kohlheyer, Dietrich, Wiechert, W., Drepper, T., Karl-Erich Jaeger, Binder, Dennis, Delvigne, Frank, Jaeger, K.-E., Alexander Grünberger, Delvigne, F., Grünberger, A., Thomas Drepper, Frank Delvigne   +20 more
core   +1 more source