Results 131 to 140 of about 1,113,115 (292)

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Phenotypic heterogeneity of delta–beta thalassemia

Indian Journal of Pathology and Microbiology, 2019
Sunita Sharma, Shivali Sehgal, Reena Das, Sameer Gulati   +3 more
doaj   +1 more source

Genetic neurocognitive profile of autism unveiled with gene transcription

Neurobiology of Disease
How neurocognitive processes elaborate phenotypic heterogeneity within autism spectrum disorder (ASD) remains unknown. Applying the principal component analysis to the Neurosynth database, we established neurocognitive profiles to characterize the ...
Yingxing Zhang, Fangfang Li, Hongli Wu, Wei Du, Jianhua Shu, Anqing Wang, Chunsheng Xu, Chuanfu Li, Ya Wang, Sheng Hu   +9 more
doaj   +1 more source

Bauch_etal_data_Telomeres-and-phenotypic-quality-ProcRSocB

, 2013
Bauch_etal_data_Telomeres-and-phenotypic-quality ...
Peter H. Becker (2913659), Christina Bauch (3192042), Simon Verhulst (143968)   +2 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Bacteriophage-driven microbial phenotypic heterogeneity: ecological and biogeochemical importance

npj Biofilms and Microbiomes
Bacteriophages (phages) reprogram host metabolism and generate phenotypic heterogeneity, yet the mechanisms and ecological implications remain poorly understood representing a major knowledge gap in microbial ecology.
Xiaolong Liang, Shuo Yang, Mark Radosevich, Yongfeng Wang, Ning Duan, Yongfeng Jia   +5 more
doaj   +1 more source

Enhancers mapping uncovers phenotypic heterogeneity and evolution in patients with luminal breast cancer

, 2017
The degree of intrinsic and interpatient phenotypic heterogeneity and its role in tumour evolution is poorly understood. Phenotypic divergence can be achieved via the inheritance of alternative transcriptional programs1,2.
Shousha, S., Magnani, L., Saiakhova, A., Kate Goddard, Pongor, L. S., Peter Scacheri, Barry, P., Scacheri, P., Alina Saiakhova, Pruneri, G., Goddard, K., Edina Erdős, Erd?s, E., Giacomo Corleone, Vingiani, A., Lőrinc Sándor Pongor, Corleone, G., Gy?rffy, B., Gaia Schiavon, Patten, D. K., Hadjiminas, D. J., Andrea Vingiani, Dimitri J. Hadjiminas, Luca Magnani, Carlo Palmieri, Raul C. Coombes, Schiavon, G., Balázs Győrffy, Giancarlo Pruneri, Sami Shousha, Coombes, R. C., Palmieri, C., Peter Barry, Darren K. Patten   +33 more
core   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source