Results 121 to 130 of about 1,113,115 (292)
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Biocides and phenotypic heterogeneity
An overview of our findings regarding the interplay between phenotypic heterogeneity in bacteria and ...
Nordholt, Niclas
core
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Transcription termination factor Rho and microbial phenotypic heterogeneity
, 2017 International audiencePopulations of genetically identical microorganisms exhibit high degree of cell-to-cell phenotypic diversity even when grown in uniform environmental conditions.
Bidnenko, Elena +3 more
core +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Phenotypic heterogeneity driven by nutrient limitation promotes growth in fluctuating environments
, 2016 Most microorganisms live in environments where nutrients are limited and fluctuate over time. Cells respond to nutrient fluctuations by sensing and adapting their physiological state.
Meibom, A. +13 more
core +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Prostate cancer cells converge to an inflammatory-like state upon metastatic dissemination
Nature CommunicationsIdentifying drivers of cancer progression to guide treatment selection is hindered by our limited understanding of tumor heterogeneity and its impact on tumor evolution.
Tina Keshavarzian +21 more
doaj +1 more source
Infection and Drug Resistance, 2020 Chao Liu, 1, 2 Pengcheng Du, 3 Jiankang Zhao, 2 Binbin Li, 2 Chunlei Wang, 2 Lingxiao Sun, 2, 4 Binghuai Lu, 2 Yimin Wang, 2 Yingmei Liu, 2 Bin Cao 1, 2, 4– 6 1Peking Union Medical College, Institute of Respiratory Medicine, Chinese Academy of ...
Liu C +9 more
doaj